Beneficial Effects of Ginger Extract on Eye Fatigue and Shoulder Stiffness: A Randomized, Double-Blind, and Placebo-Controlled Parallel Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Subjects
2.3. Study Design
2.4. Ocular Blood Flow
2.5. Peripheral Blood Flow
2.6. Visual Analog Scales (VAS)
2.7. Shoulder Muscle Stiffness
2.8. Statistical Analysis
3. Results
3.1. Population Characteristics
3.2. Ginger Enhances Peripheral Blood Flow Velocity
3.3. Ginger Alleviates Eye Fatigue and Shoulder Stiffness
3.4. Safety of Ginger
4. Discussion
5. Conclusions
6. Patents
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Placebo (n = 49) | Ginger (n = 51) | p-Value | |
---|---|---|---|
Age (years) | 51.1 ± 12.0 | 52.0 ± 10.2 | 0.694 |
Male/Female | 12/37 | 13/38 | - |
Height (cm) | 159.7 ± 7.8 | 159.5 ± 6.8 | 0.902 |
Body weight (kg) | 55.3 ± 11.9 | 56.6 ± 11.6 | 0.626 |
BMI (kg/m2) | 21.5 ± 3.3 | 22.1 ± 3.8 | 0.429 |
Body fat percentage (%) | 24.8 ± 7.5 | 26.1 ± 8.1 | 0.482 |
Systolic blood pressure (mmHg) | 109.9 ± 18.0 | 112.4 ± 15.2 | 0.673 |
Diastolic blood pressure (mmHg) | 66.8 ± 12.9 | 68.3 ± 10.5 | 0.902 |
Heart rate (beats per min) | 68.8 ± 12.5 | 69.7 ± 9.0 | 0.469 |
White blood cell count (×103/mL) | 5.23 ± 1.55 | 5.45 ± 1.19 | 0.438 |
Red blood cell count (×106/mL) | 4.57 ± 0.43 | 4.64 ± 0.45 | 0.480 |
Hemoglobin (g/dL) | 13.6 ± 1.4 | 14.0 ± 1.3 | 0.102 |
Hematocrit (%) | 42.3 ± 3.9 | 43.4 ± 3.7 | 0.151 |
Platelet count (×104/mL) | 24.6 ± 6.3 | 25.4 ± 6.0 | 0.532 |
AST (IU/L) | 21.3 ± 5.0 | 21.0 ± 6.0 | 0.797 |
ALT (IU/L) | 18.9 ± 9.2 | 19.6 ± 12.9 | 0.746 |
γ-GTP (IU/L) | 21.4 ± 8.7 | 28.2 ± 33.8 | 0.176 |
LDH(IU/L) | 188 ± 26 | 188 ± 24 | 0.968 |
Choline esterase (IU/L) | 316 ± 68 | 345 ± 70 * | 0.041 |
Alkaline phosphatase (IU/L) | 65.9 ± 19.1 | 67.5 ± 16.9 | 0.676 |
Amylase (IU/L) | 80.1 ± 28.9 | 96.9 ± 92.1 | 0.227 |
Total protein (g/dL) | 7.44 ± 0.45 | 7.41 ± 0.37 | 0.708 |
Total bilirubin (mg/dL) | 0.79 ± 0.28 | 0.73 ± 0.22 | 0.233 |
Albumin (g/dL) | 4.57 ± 0.28 | 4.53 ± 0.25 | 0.473 |
Uric acid (mg/dL) | 4.69 ± 1.10 | 4.89 ± 1.39 | 0.436 |
Blood urea nitrogen (mg/dL) | 13.5 ± 3.3 | 13.2 ± 4.4 | 0.720 |
Creatinine (mg/dL) | 0.691 ± 0.131 | 0.690 ± 0.165 | 0.968 |
eGFR (mL/min/1.73 m2) | 98.9 ± 21.0 | 99.5 ± 21.9 | 0.886 |
Total cholesterol (mg/dL) | 228 ± 42 | 232 ± 40 | 0.613 |
LDL cholesterol (mg/dL) | 136 ± 35 | 141 ± 33 | 0.523 |
HDL cholesterol (mg/dL) | 69.4 ± 20.4 | 70.8 ± 17.2 | 0.728 |
LDL/HDL ratio | 2.13 ± 0.82 | 2.10 ± 0.65 | 0.846 |
Triglycerides (mg/dL) | 110.9 ± 97.9 | 107.9 ± 63.6 | 0.856 |
Fasting blood glucose (mg/dL) | 97.3 ± 8.7 | 95.5 ± 9.0 | 0.327 |
Placebo | Ginger | p-Value | |
---|---|---|---|
Retinal blood flow | |||
All (n = 49, 51) | 10.4 ± 3.9 | 9.4 ± 3.3 | 0.143 |
Male (n = 12, 13) | 10.1 ± 3.0 | 9.5 ± 3.8 | 0.662 |
Female (n = 37, 38) | 10.6 ± 4.2 | 9.4 ± 3.2 | 0.160 |
Blood flow in optic disc | |||
All (n = 49, 51) | 34.7 ± 6.3 | 34.1 ± 6.3 | 0.588 |
Male (n = 12, 13) | 30.6 ± 4.8 | 31.1 ± 5.8 | 0.819 |
Female (n = 37, 38) | 36.1 ± 6.2 | 35.1 ± 6.2 | 0.480 |
Peripheral blood Flow Velocity in Deep Vessels | |||
All (n = 49, 51) | 38.9 ± 15.1 | 36.6 ± 13.4 | 0.438 |
Male (n = 12, 13) | 31.8 ± 13.5 | 38.0 ± 17.0 | 0.322 |
Female (n = 37, 38) | 41.2 ± 15.1 | 36.2 ± 12.2 | 0.118 |
Peripheral blood Flow Velocity in Superficial Vessels | |||
All (n = 49, 51) | 33.3 ± 7.7 | 31.5 ± 7.7 | 0.226 |
Male (n = 12, 13) | 30.3 ± 7.8 | 30.6 ± 9.3 | 0.917 |
Female (n = 37, 38) | 34.4 ± 7.5 | 31.8 ± 7.2 | 0.131 |
VAS of Eye Fatigue (mm) | |||
All (n = 49, 51) | 57.8 ± 17.7 | 64.7 ± 14.4 * | 0.035 |
Male (n = 12, 13) | 58.9 ± 19.3 | 66.1 ± 16.5 | 0.328 |
Female (n = 37, 38) | 57.4 ± 17.5 | 64.2 ± 13.8 | 0.065 |
VAS of Shoulder Stiffness (mm) | |||
All (n = 49, 51) | 65.6 ± 20.2 | 68.6 ± 17.2 | 0.429 |
Male (n = 12, 13) | 63.5 ± 24.2 | 67.0 ± 16.2 | 0.680 |
Female (n = 37, 38) | 66.3 ± 19.1 | 69.2 ± 17.8 | 0.502 |
VAS of Body Warmth (mm) | |||
All (n = 49, 51) | 52.4 ± 14.2 | 53 ± 16.5 | 0.834 |
Male (n = 12, 13) | 54.5 ± 12.2 | 14.4 ± 4.2 | 0.999 |
Female (n = 37, 38) | 51.7 ± 14.8 | 53 ± 17.4 | 0.740 |
Shoulder Muscle Stiffness | |||
All (n = 49, 51) | 32.1 ± 4.8 | 32.4 ± 6.4 | 0.788 |
Male (n = 12, 13) | 29.9 ± 2.6 | 29.1 ± 5.4 | 0.647 |
Female (n = 37, 38) | 32.8 ± 5.1 | 33.5 ± 6.3 | 0.591 |
Male | Female | |||
---|---|---|---|---|
≥51 Years Old | <51 Years Old | ≥51 Years Old | <51 Years Old | |
(n; Placebo, Ginger) | (n = 9, 9) | (n = 3, 4) | (n = 21, 20) | (n = 16, 18) |
Retinal blood flow | −0.0 (−2.4, 2.4) | 3.0 (1.5, 4.5) ** | −0.2 (−1.1, 0.7) | −0.0 (−0.9, 0.8) |
Blood flow in optic disc | 0.7 (−3.2, 4.6) | 2.4 (−1.9, 6.6) | −0.9 (−3.9, 2.1) | −1.7 (−4.5, 1.0) |
Peripheral blood Flow Velocity in Deep Vessels | −12.4 (−27.9, 3.1) | 2.0 (−9.9, 13.9) | 2.8 (−5.2, 10.9) | 10.9 (2.4, 19.5) * |
Peripheral blood Flow Velocity in Superficial Vessels | −0.3 (−12.1, 11.5) | −3.1 (−12.1, 5.9) | 4.3 (0.5, 8.1) * | −0.3 (−5.9, 5.4) |
VAS of Eye Fatigue (mm) | −7.4 (−27.2, 12.4) | −4.6 (−31.4, 22.2) | −1.2 (−13.8, 11.3) | −16.8 (−30.9, −2.6) * |
VAS of Shoulder Stiffness (mm) | −5.5 (−28.5, 17.5) | 6.6 (−18.3, 31.6) | −5.8 (−19.2, 7.7) | −12.9 (−24.2, −1.7) * |
VAS of Body Warmth (mm) | 3.6 (−15.4, 22.5) | 33.3 (9.6, 57.1) * | 4.7 (−8.2, 17.7) | 1.5 (−14.0, 17.0) |
Shoulder Muscle Stiffness | −1.6 (−8.3, 5.1) | −3.3 (−6.7, 0.1) | 0.8 (−3.4, 5.0) | −1.3 (−4.8, 2.1) |
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Higashikawa, F.; Nakaniida, Y.; Li, H.; Liang, L.; Kanno, K.; Ogawa-Ochiai, K.; Kiuchi, Y. Beneficial Effects of Ginger Extract on Eye Fatigue and Shoulder Stiffness: A Randomized, Double-Blind, and Placebo-Controlled Parallel Study. Nutrients 2024, 16, 2715. https://doi.org/10.3390/nu16162715
Higashikawa F, Nakaniida Y, Li H, Liang L, Kanno K, Ogawa-Ochiai K, Kiuchi Y. Beneficial Effects of Ginger Extract on Eye Fatigue and Shoulder Stiffness: A Randomized, Double-Blind, and Placebo-Controlled Parallel Study. Nutrients. 2024; 16(16):2715. https://doi.org/10.3390/nu16162715
Chicago/Turabian StyleHigashikawa, Fumiko, Yuta Nakaniida, Hongyang Li, Lian Liang, Keishi Kanno, Keiko Ogawa-Ochiai, and Yoshiaki Kiuchi. 2024. "Beneficial Effects of Ginger Extract on Eye Fatigue and Shoulder Stiffness: A Randomized, Double-Blind, and Placebo-Controlled Parallel Study" Nutrients 16, no. 16: 2715. https://doi.org/10.3390/nu16162715
APA StyleHigashikawa, F., Nakaniida, Y., Li, H., Liang, L., Kanno, K., Ogawa-Ochiai, K., & Kiuchi, Y. (2024). Beneficial Effects of Ginger Extract on Eye Fatigue and Shoulder Stiffness: A Randomized, Double-Blind, and Placebo-Controlled Parallel Study. Nutrients, 16(16), 2715. https://doi.org/10.3390/nu16162715