Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders—An Overview of Experimental Evidence
Abstract
:1. Introduction
2. Exploring the Neuroprotective Potential of Resveratrol
3. Stress-Related Anxiety Disorders: State of the Art
4. Abnormalities in Neuronal Circuits and Neurotransmitter Levels in the Pathogenesis of Stress-Related Anxiety Disorders and the Efficacy of RES in Their Correction
5. Aberrations in Cerebral Blood Flow in the Pathogenesis of Stress-Related Anxiety Disorders and the Efficacy of RES in Their Amelioration
6. Neuronal Plasticity Abnormalities in the Pathogenesis of Stress-Related Anxiety Disorders and the Efficacy of Resveratrol in Correction
7. Peripheral Inflammation and Neuroinflammation in the Pathogenesis of Stress-Related Anxiety Disorders and the Efficacy of Resveratrol in Their Treatment
8. Mitochondrial Dysfunction in the Pathogenesis of Stress-Related Anxiety Disorders and the Efficacy of RES in Their Correction
9. Oxidative Stress: Implications in the Pathogenesis of Stress-Related Anxiety Disorders and the Therapeutic Potential of RES
10. Blunted LHPA Axis Function in the Pathogenesis of Stress-Related Anxiety Disorders and the Efficacy of RES in Their Correction
11. Abnormalities in the Gut–Brain and Liver–Brain Axes in the Pathogenesis of Stress-Related Anxiety Disorders and the Efficacy of Resveratrol in Their Correction
12. SIRT1-Dependent Pathways and the Dual Effect of Resveratrol on Anxiety Behavior
13. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Organism Neuronal Culture | Molecular Target | Effects of RES | References |
---|---|---|---|
PC 12 cells | p53 | RES prevents the proapoptotic increase in nuclear p53 induced by high glucose levels. | [19] |
N9 microglial cells | NF-B | RES reduces apoptotic neuronal cell death induced by neuroinflammation. | [20] |
primary cultured neurons | SIRT1, SIRT3, PGC1 | RES may ameliorate manganese (Mn)-induced neuronal injury and mitochondrial dysfunction in primary cultured neurons by activating the SIRT1/PGC-1 signaling pathway, with SIRT3 being essential for promoting mitochondrial biogenesis and attenuating Mn-induced mitochondrial dysfunction. | [21] |
H19-7 hippocampal neuronal cells | superoxide dismutase, catalase, glutathione reductase | RES treatment attenuated the accumulation of lipid peroxide levels, upregulated antioxidant activities, and improved the expression of memory-associated proteins in A-treated H19-7 cells. | [22] |
primary cultures of rat cortical neurons | Nrf-2 | RES treatment at various time points increased neuronal viability and inhibited neuronal apoptosis in vitro, at least in part, by enhancing the activation of the Nrf-2 signaling pathway. | [23] |
culture of dopaminergic neurons | intracellular free calcium, reactive oxygen species | RES enhances cell viability and reduces apoptosis by attenuating MA-induced reactive oxygen species (ROS) production and calcium overload. It protects dopaminergic neurons from cytotoxicity by inhibiting and oxidative stress. | [24] |
mice mesencephalic and cortical primary cultures | complex III of mitochondrial respiratory chain | A significant reduction in glutamate-induced radical formation was observed in cultures treated with resveratrol, demonstrating the antioxidant potential of RES. | [25] |
rat cerebellar granule neurons (CGNs) | mitochondrial complex I, SIRT1 | RES exhibits beneficial effects against mitochondrial dysfunction and prevents cell death in neuronal cells. | [26] |
SH-SY5Y cells | AMPK | RES rescues SH-SY5Y cells from oxygen-glucose deprivation (OGD)-mediated mitochondrial deficiency and restores the transcript expression levels of PGC-1 and mitochondrial genes. | [27] |
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Tseilikman, V.E.; Tseilikman, O.B.; Yegorov, O.N.; Brichagina, A.A.; Karpenko, M.N.; Tseilikman, D.V.; Shatilov, V.A.; Zhukov, M.S.; Novak, J. Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders—An Overview of Experimental Evidence. Nutrients 2024, 16, 2856. https://doi.org/10.3390/nu16172856
Tseilikman VE, Tseilikman OB, Yegorov ON, Brichagina AA, Karpenko MN, Tseilikman DV, Shatilov VA, Zhukov MS, Novak J. Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders—An Overview of Experimental Evidence. Nutrients. 2024; 16(17):2856. https://doi.org/10.3390/nu16172856
Chicago/Turabian StyleTseilikman, Vadim E., Olga B. Tseilikman, Oleg N. Yegorov, Alina A. Brichagina, Marina N. Karpenko, David V. Tseilikman, Vladislav A. Shatilov, Maxim S. Zhukov, and Jurica Novak. 2024. "Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders—An Overview of Experimental Evidence" Nutrients 16, no. 17: 2856. https://doi.org/10.3390/nu16172856