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Nutrients
Volume 16
Issue 17
10.3390/nu16172891
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Review

The Influence of Intestinal Microbiota on BDNF Levels

by
Marta Molska
1,*,
Kinga Mruczyk
1,
Angelika Cisek-Woźniak
1,
Wojciech Prokopowicz
2,
Patrycja Szydełko
1,
Zuzanna Jakuszewska
1,
Karolina Marzec
1 and
Martyna Trocholepsza
1
1
Department of Dietetics, Faculty of Physical Culture in Gorzow Wlkp., Poznan University of Physical Education, Estkowskiego 13, 66-400 Gorzow Wielkopolski, Poland
2
GSP Clinic Limited Liability Company, Kostrzyńska Street 12, 66-400 Gorzow Wielkopolski, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(17), 2891; https://doi.org/10.3390/nu16172891
Submission received: 25 July 2024 / Revised: 24 August 2024 / Accepted: 26 August 2024 / Published: 29 August 2024
(This article belongs to the Special Issue The Latest Research on Probiotics: Nourishing Health or Pathways to Disease Resolution)
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Abstract

The regulation of neurogenesis, the complex process of producing and differentiating new brain tissue cells, is influenced by a complex interaction of internal and external factors. Over the past decade, extensive research has been conducted on neurotrophins and their key role in adult neurogenesis, as well as their impact on diseases such as depression. Among neurotrophins, the brain-derived neurotrophic factor (BDNF) has been the subject of comprehensive studies on adult neurogenesis, and scientific evidence supports its necessity for neurogenesis in the subventricular zone of the hippocampus. A novel area of research is the emerging role of gut microbiota as a significant contributor to neurogenesis and neurotrophin production. Studies have shown that reduced BDNF levels can lead to mood disorders, which are observed in intestinal dysbiosis, characterized by an imbalance in the composition and quantity of the intestinal microbiota. There is evidence in the literature that there is a link between brain function and gut microbiota. Physical activity, and especially the regularity and intensity of exercise, is important in relation to the level of BDNF and the intestinal microbiota. Probiotics, prebiotics and physical activity may have a positive effect on the intestinal microbiota, and therefore also on the level of the brain-derived neurotrophic factor.
Keywords: BDNF; neurotrophins; neurogenesis; microbiota; microbiome; probiotics; prebiotics; physical activity; dysbiosis BDNF; neurotrophins; neurogenesis; microbiota; microbiome; probiotics; prebiotics; physical activity; dysbiosis

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MDPI and ACS Style

Molska, M.; Mruczyk, K.; Cisek-Woźniak, A.; Prokopowicz, W.; Szydełko, P.; Jakuszewska, Z.; Marzec, K.; Trocholepsza, M. The Influence of Intestinal Microbiota on BDNF Levels. Nutrients 2024, 16, 2891. https://doi.org/10.3390/nu16172891

AMA Style

Molska M, Mruczyk K, Cisek-Woźniak A, Prokopowicz W, Szydełko P, Jakuszewska Z, Marzec K, Trocholepsza M. The Influence of Intestinal Microbiota on BDNF Levels. Nutrients. 2024; 16(17):2891. https://doi.org/10.3390/nu16172891

Chicago/Turabian Style

Molska, Marta, Kinga Mruczyk, Angelika Cisek-Woźniak, Wojciech Prokopowicz, Patrycja Szydełko, Zuzanna Jakuszewska, Karolina Marzec, and Martyna Trocholepsza. 2024. "The Influence of Intestinal Microbiota on BDNF Levels" Nutrients 16, no. 17: 2891. https://doi.org/10.3390/nu16172891

APA Style

Molska, M., Mruczyk, K., Cisek-Woźniak, A., Prokopowicz, W., Szydełko, P., Jakuszewska, Z., Marzec, K., & Trocholepsza, M. (2024). The Influence of Intestinal Microbiota on BDNF Levels. Nutrients, 16(17), 2891. https://doi.org/10.3390/nu16172891

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