Effect of Selenium and Selenoproteins on Radiation Resistance
Abstract
:1. Introduction
2. Selenoproteins and Their Anti-Radiation Effects
2.1. Glutathione Peroxidases (GPXs)
2.1.1. Glutathione Peroxidase 1 (GPX1)
2.1.2. Glutathione Peroxidase 4 (GPX4)
2.2. Selenoprotein P (SELENOP)
2.3. Selenoprotein S (SELENOS)
2.4. Selenoprotein I (SELENOI)
3. Radiation Resistance Mechanism of Selenium and Selenoproteins
3.1. Improves Oxidative Damage
3.2. Protecting DNA
3.3. Regulating Cell Apoptosis
3.4. Regulating Immune System
3.4.1. MAPK Signaling Pathways and PI3K/AKT Signaling Pathway
3.4.2. Inflammation Signaling Pathway
4. The Application of Selenium and Selenoproteins in the Treatment of Radiation-Related Diseases
4.1. Lung Injury and Treatment
4.2. Hematopoietic System
4.3. Gastrointestinal System
4.4. Kidney and Liver
4.5. Cardiovascular System
5. Effects of Selenium and Selenoproteins Doses on Radiation Resistance
6. Summary and Prospects
Author Contributions
Funding
Conflicts of Interest
Abbreviations
References
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Selenoprotein | Position | Action Mechanism | Reference |
---|---|---|---|
GPX1 | Erythrocyte | Eliminate reactive oxygen species to reduce radiation damage; Promote DNA repair to prevent radiation injury; Exert anticancer effects to achieve the treat of radiation damage. | [19,20,21,22,23,24,25,26] |
GPX4 | Cytoplasm, mitochondria and nucleus | Inhibit lipid peroxidation to reduce radiation damage; Regulate apoptotic markers to alleviate radiation-induced cell apoptosis; Decrease the synthesis of 8-oxo-dG to minimize DNA damage. | [27,28,29,30] |
SELENOP | Plasma | Inhibition of radiation-induced late reactive oxygen species accumulation; Reduction of tumor occurrence as a tumor suppressor in radiation-induced inflammatory carcinogenesis; Regulation of immune cell function as an antioxidant for immune cells. | [31,32,33,34,35,36,37] |
SELENOS | Endoplasmic reticulum | Alleviate radiation-induced endoplasmic reticulum stress. | [38,39] |
SELENOI | The Golgi apparatus | Plays a crucial role in T cell activation, enhancing the immune response of immune cells. | [40,41] |
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Zhang, S.; Zhang, G.; Wang, P.; Wang, L.; Fang, B.; Huang, J. Effect of Selenium and Selenoproteins on Radiation Resistance. Nutrients 2024, 16, 2902. https://doi.org/10.3390/nu16172902
Zhang S, Zhang G, Wang P, Wang L, Fang B, Huang J. Effect of Selenium and Selenoproteins on Radiation Resistance. Nutrients. 2024; 16(17):2902. https://doi.org/10.3390/nu16172902
Chicago/Turabian StyleZhang, Shidi, Guowei Zhang, Pengjie Wang, Lianshun Wang, Bing Fang, and Jiaqiang Huang. 2024. "Effect of Selenium and Selenoproteins on Radiation Resistance" Nutrients 16, no. 17: 2902. https://doi.org/10.3390/nu16172902