6′-Sialyllactose Alleviates Muscle Fatigue through Reduced Blood Lactate Level after Treadmill Exercise in Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal and Treatments
2.2. Serum Analysis
2.3. Treadmill Exercise
2.4. Blood Lactate and Glucose Measurements
2.5. Western Blotting
2.6. Statistical Analysis
3. Results
3.1. Effects of 6′-SL on Physiological Characteristics
3.2. 6′-SL Decreases the Level of Fatigue-Related Factors during Exercise
3.3. 6′-SL Increases Energy Metabolism in the GAS Muscle
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
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Control (n = 8) | 6′-SL (n = 8) | p-Value | |
---|---|---|---|
Liver injury marker | |||
ALT (U/L) | 22.25 ± 12.31 | 14.25 ± 5.50 | 0.1155 |
AST (U/L) | 113.75 ± 25.76 | 104.75 ± 25.66 | 0.4953 |
ALP (U/L) | 41.75 ± 2.05 | 41.75 ± 5.60 | >0.9999 |
T-bilirubin (mg/dL) | 0.06 ± 0.01 | 0.05 ± 0.01 | 0.2663 |
ALB (d/dL) | 2.78 ± 0.19 | 2.65 ± 0.21 | 0.2298 |
Total protein (g/dL) | 3.91 ± 0.24 | 3.70 ± 0.21 | 0.0798 |
Kidney injury marker | |||
Creatinine (mg/dL) | 0.41 ± 0.08 | 0.37 ± 0.03 | 0.1905 |
Fatigue marker | |||
BUN (mg/dL) | 23.25 ± 3.24 | 19.75 ± 2.92 * | 0.0395 |
Lipid profiles | |||
LDL (mg/dL) | 12.38 ± 5.24 | 9.75 ± 1.67 | 0.1981 |
HDL (mg/dL) | 70.13 ± 9.60 | 67.75 ± 6.54 | 0.5722 |
TG (mg/dL) | 72.25 ± 19.25 | 63.50 ± 15.41 | 0.3325 |
TC (mg/dL) | 85.13 ± 13.59 | 79.75 ± 8.10 | 0.3529 |
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Park, E.-J.; Kim, L.-L.; Lee, J.-O.; Lee, H.-Y.; Kim, Y.-A.; Go, H. 6′-Sialyllactose Alleviates Muscle Fatigue through Reduced Blood Lactate Level after Treadmill Exercise in Mice. Nutrients 2024, 16, 2957. https://doi.org/10.3390/nu16172957
Park E-J, Kim L-L, Lee J-O, Lee H-Y, Kim Y-A, Go H. 6′-Sialyllactose Alleviates Muscle Fatigue through Reduced Blood Lactate Level after Treadmill Exercise in Mice. Nutrients. 2024; 16(17):2957. https://doi.org/10.3390/nu16172957
Chicago/Turabian StylePark, Eun-Jung, Li-La Kim, Jie-Oh Lee, Hay-Young Lee, Yong-An Kim, and Hiroe Go. 2024. "6′-Sialyllactose Alleviates Muscle Fatigue through Reduced Blood Lactate Level after Treadmill Exercise in Mice" Nutrients 16, no. 17: 2957. https://doi.org/10.3390/nu16172957