Next Article in Journal
Higher Animal-Based Protein Intake Levels Show a Greater Likelihood of Having Metabolic Syndrome in Single-Person Households Among Korean Adults
Previous Article in Journal
The Extraction, Biosynthesis, Health-Promoting and Therapeutic Properties of Natural Flavanone Eriodictyol
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Healthy Lifestyle Behaviors Attenuate the Effect of Poor Sleep Patterns on Chronic Kidney Disease Risk: A Prospective Study from the UK Biobank

1
Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
2
Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan 250002, China
*
Authors to whom correspondence should be addressed.
Nutrients 2024, 16(23), 4238; https://doi.org/10.3390/nu16234238
Submission received: 10 November 2024 / Revised: 2 December 2024 / Accepted: 6 December 2024 / Published: 8 December 2024
(This article belongs to the Section Nutrition Methodology & Assessment)

Abstract

Objectives: This study aimed to assess the impact of modifiable lifestyle behaviors on the association between sleep patterns and chronic kidney disease (CKD) risk. Methods: This study included 294,215 UK Biobank participants initially without CKD, followed until 13 October 2023. Sleep patterns were derived from five sleep factors, including sleep duration, chronotype, insomnia, snoring, and daytime dozing. The healthy lifestyle score (HLS) was newly calculated based on smoking status, physical activity, diet, body mass index, and mental health. Cox’s proportional hazards models were used to assess the associations between sleep patterns, HLS, and CKD risk. Results: A total of 17,357 incident CKD cases were identified during a median follow-up of 14.5 (interquartile range: 13.7–15.3) years. Both sleep patterns and HLS were independently associated with increased CKD risk (p-trend < 0.001). Importantly, the HLS was found to modify the association between sleep patterns and CKD risk (p-interaction = 0.026). Among participants with a low HLS, medium (HR = 1.12; 95% CI 1.05–1.19) and poor sleep patterns (HR = 1.23; 95% CI 1.17–1.30) increased CKD risk to varying degrees, whereas no significant association was observed for a high HLS. Moreover, the combination of a low HLS and poor sleep pattern significantly increased the risk of incident CKD (HR = 2.19; 95% CI 2.00–2.40). Conclusions: A high HLS may significantly reduce CKD risk associated with poor sleep, whereas a low HLS may exacerbate this risk. These findings underscore the critical importance of lifestyle interventions as a primary prevention strategy for CKD.
Keywords: chronic kidney disease; lifestyles; sleep patterns; prospective cohort study chronic kidney disease; lifestyles; sleep patterns; prospective cohort study

Share and Cite

MDPI and ACS Style

Lin, X.; Lv, J.; Zhang, S.; Ma, X.; Zhang, X.; Wang, C.; Zhang, T. Healthy Lifestyle Behaviors Attenuate the Effect of Poor Sleep Patterns on Chronic Kidney Disease Risk: A Prospective Study from the UK Biobank. Nutrients 2024, 16, 4238. https://doi.org/10.3390/nu16234238

AMA Style

Lin X, Lv J, Zhang S, Ma X, Zhang X, Wang C, Zhang T. Healthy Lifestyle Behaviors Attenuate the Effect of Poor Sleep Patterns on Chronic Kidney Disease Risk: A Prospective Study from the UK Biobank. Nutrients. 2024; 16(23):4238. https://doi.org/10.3390/nu16234238

Chicago/Turabian Style

Lin, Xia, Jiali Lv, Shuai Zhang, Xiaoyan Ma, Xiaofeng Zhang, Cheng Wang, and Tao Zhang. 2024. "Healthy Lifestyle Behaviors Attenuate the Effect of Poor Sleep Patterns on Chronic Kidney Disease Risk: A Prospective Study from the UK Biobank" Nutrients 16, no. 23: 4238. https://doi.org/10.3390/nu16234238

APA Style

Lin, X., Lv, J., Zhang, S., Ma, X., Zhang, X., Wang, C., & Zhang, T. (2024). Healthy Lifestyle Behaviors Attenuate the Effect of Poor Sleep Patterns on Chronic Kidney Disease Risk: A Prospective Study from the UK Biobank. Nutrients, 16(23), 4238. https://doi.org/10.3390/nu16234238

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop