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Nutrients
Volume 16
Issue 4
10.3390/nu16040486
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Article

Non-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio

by
Shiri Weinstein
1,2,
Elad Maor
2,3,
Alon Kaplan
1,2,
Tammy Hod
2,4,5,
Avshalom Leibowitz
1,2,6,
Ehud Grossman
7 and
Gadi Shlomai
1,2,6,8,*
1
Internal Medicine D, Sheba Medical Center, Ramat Gan 5262504, Israel
2
Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel
3
Leviev Heart Center, Sheba Medical Center, Ramat Gan 5262504, Israel
4
Renal Transplant Center, Sheba Medical Center, Ramat Gan 5262504, Israel
5
Nephrology Department, Sheba Medical Center, Ramat Gan 5262504, Israel
6
The Hypertension Unit, Sheba Medical Center, Ramat Gan 5262504, Israel
7
Adelson School of Medicine, Ariel University, Ariel 407000, Israel
8
The Institute of Endocrinology, Diabetes and Metabolism, Sheba Medical Center, Ramat Gan 5262504, Israel
*
Author to whom correspondence should be addressed.
Nutrients 2024, 16(4), 486; https://doi.org/10.3390/nu16040486
Submission received: 29 December 2023 / Revised: 5 February 2024 / Accepted: 6 February 2024 / Published: 8 February 2024
(This article belongs to the Special Issue Obesity and Cardiovascular Disease: Mechanistic Insights and Nutritional Management Strategies)
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Abstract

Background: Obesity is associated with dyslipidemia, and weight loss can improve obese patients’ lipid profile. Here, we assessed whether non-interventional weight changes are associated with alterations in lipid profile, particularly the triglyceride (TG)-to-high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C). Methods: In this retrospective analysis of subjects referred to medical screening, body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), TG, and HDL-C levels were measured annually. Patients were divided according to BMI changes between visits. The primary outcomes were the changes in LDL-C, TG, HDL-C, and the TG/HDL-C ratio between visits. Results: The final analysis included 18,828 subjects. During the year of follow-up, 9.3% of the study population lost more than 5% of their weight and 9.2% gained more than 5% of their weight. The effect of weight changes on TG and on the TG/HDL-C ratio was remarkable. Patients with greater BMI increases showed greater increases in their TG/HDL-C ratio, and conversely, a decreased BMI level had lower TG/HDL-C ratios. This is true even for moderate changes of more than 2.5% in BMI. Conclusions: Non-interventional weight changes, even modest ones, are associated with significant alterations in the lipid profile. Understanding that modest, non-interventional weight changes are associated with alterations in the TG/HDL-C ratio may aid in better risk stratification and primary prevention of CV morbidity and mortality.
Keywords: weight change; BMI change; lipids; triglyceride-to-HDL ratio weight change; BMI change; lipids; triglyceride-to-HDL ratio
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MDPI and ACS Style

Weinstein, S.; Maor, E.; Kaplan, A.; Hod, T.; Leibowitz, A.; Grossman, E.; Shlomai, G. Non-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio. Nutrients 2024, 16, 486. https://doi.org/10.3390/nu16040486

AMA Style

Weinstein S, Maor E, Kaplan A, Hod T, Leibowitz A, Grossman E, Shlomai G. Non-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio. Nutrients. 2024; 16(4):486. https://doi.org/10.3390/nu16040486

Chicago/Turabian Style

Weinstein, Shiri, Elad Maor, Alon Kaplan, Tammy Hod, Avshalom Leibowitz, Ehud Grossman, and Gadi Shlomai. 2024. "Non-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio" Nutrients 16, no. 4: 486. https://doi.org/10.3390/nu16040486

APA Style

Weinstein, S., Maor, E., Kaplan, A., Hod, T., Leibowitz, A., Grossman, E., & Shlomai, G. (2024). Non-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio. Nutrients, 16(4), 486. https://doi.org/10.3390/nu16040486

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