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Nutrients
Volume 17
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10.3390/nu17071187
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Article

The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats

by
Marko Gerić
1,†,
Lucia Nanić
2,†,
Vedran Micek
3,
Ivana Novak Jovanović
1,
Goran Gajski
1,
Dubravka Rašić
1,
Tatjana Orct
4,
Marija Ljubojević
1,
Dean Karaica
1,
Jasna Jurasović
3,
Ivana Vrhovac Madunić
1,
Maja Peraica
1,
Ivan Sabolić
1,
Vanessa Moraes de Andrade
5,
Davorka Breljak
1,* and
Ivica Rubelj
2,*
1
Division of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia
2
Laboratory for Molecular and Cellular Biology, Division of Molecular Biology, Ruđer Bošković Institute, 10000 Zagreb, Croatia
3
Animal Breeding Unit, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia
4
Division of Occupational and Environmental Health, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia
5
Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina–UNESC, Criciúma 88806-000, Brazil
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2025, 17(7), 1187; https://doi.org/10.3390/nu17071187
Submission received: 3 March 2025 / Revised: 25 March 2025 / Accepted: 27 March 2025 / Published: 28 March 2025
(This article belongs to the Section Geriatric Nutrition)
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Abstract

Background: Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate the potential geroprotective effects of resveratrol and melatonin in ageing rats. Methods: The animals were treated with these two compounds starting at 3 months of age and continuing until 1 year or 2 years of age. Using a multibiomarker approach, we assessed DNA damage, telomere length, and the oxidative status in their urine, liver, and kidneys. Results: Despite employing this experimental approach, our results did not provide conclusive evidence of geroprotective effects across the evaluated organs. However, we observed sex-dependent differences in response to treatment. Conclusions: Given the high potency of these two compounds, further research is warranted to explore their incorporation into daily routines as a strategy to mitigate ageing-related effects.
Keywords: ageing; resveratrol; melatonin; telomeres; oxidative stress; DNA damage ageing; resveratrol; melatonin; telomeres; oxidative stress; DNA damage

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MDPI and ACS Style

Gerić, M.; Nanić, L.; Micek, V.; Novak Jovanović, I.; Gajski, G.; Rašić, D.; Orct, T.; Ljubojević, M.; Karaica, D.; Jurasović, J.; et al. The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats. Nutrients 2025, 17, 1187. https://doi.org/10.3390/nu17071187

AMA Style

Gerić M, Nanić L, Micek V, Novak Jovanović I, Gajski G, Rašić D, Orct T, Ljubojević M, Karaica D, Jurasović J, et al. The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats. Nutrients. 2025; 17(7):1187. https://doi.org/10.3390/nu17071187

Chicago/Turabian Style

Gerić, Marko, Lucia Nanić, Vedran Micek, Ivana Novak Jovanović, Goran Gajski, Dubravka Rašić, Tatjana Orct, Marija Ljubojević, Dean Karaica, Jasna Jurasović, and et al. 2025. "The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats" Nutrients 17, no. 7: 1187. https://doi.org/10.3390/nu17071187

APA Style

Gerić, M., Nanić, L., Micek, V., Novak Jovanović, I., Gajski, G., Rašić, D., Orct, T., Ljubojević, M., Karaica, D., Jurasović, J., Vrhovac Madunić, I., Peraica, M., Sabolić, I., de Andrade, V. M., Breljak, D., & Rubelj, I. (2025). The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats. Nutrients, 17(7), 1187. https://doi.org/10.3390/nu17071187

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