Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo
Abstract
:1. Introduction
2. Materials and Methods
2.1. Reagents
2.2. Diabetes Induction
2.3. Blood Sample Collection
2.4. Oral Glucose Tolerance Test and Insulin Tolerance Test
2.5. Serum Insulin, Hepatic Inflammatory Factors and Tyr-Phosphorylated Insulin Receptor Substrate-1 Protein Expression Assay
2.6. Homeostasis Model Assessment-Insulin Resistance
2.7. Immunohistochemistry Stain
2.8. Statistical Analysis
3. Results
3.1. The Anti-Diabetic Effects of Resveratrol in MG-Treated Mice
3.2. Anti-Inflammatory Effects of Resveratrol
3.3. Resveratrol-Mediated Elevation of Liver Tyr-Phosphorylated IRS-1 Levels
3.4. IHC Stain for Pancreatic Insulin and p-Nrf2
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Cheng, A.-S.; Cheng, Y.-H.; Lee, C.-Y.; Chung, C.-Y.; Chang, W.-C. Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo. Nutrients 2015, 7, 2850-2865. https://doi.org/10.3390/nu7042850
Cheng A-S, Cheng Y-H, Lee C-Y, Chung C-Y, Chang W-C. Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo. Nutrients. 2015; 7(4):2850-2865. https://doi.org/10.3390/nu7042850
Chicago/Turabian StyleCheng, An-Sheng, Yu-Hsiang Cheng, Chi-Ying Lee, Chin-Yuan Chung, and Wen-Chang Chang. 2015. "Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo" Nutrients 7, no. 4: 2850-2865. https://doi.org/10.3390/nu7042850
APA StyleCheng, A. -S., Cheng, Y. -H., Lee, C. -Y., Chung, C. -Y., & Chang, W. -C. (2015). Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo. Nutrients, 7(4), 2850-2865. https://doi.org/10.3390/nu7042850