Next Article in Journal
Comparison of Dietary Intakes of 7-Year-Old Children Enrolled in Observational Birth Cohort Studies on the Isle of Man and in South-West England
Previous Article in Journal
Effect of Soy Isoflavones on Growth of Representative Bacterial Species from the Human Gut
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Acute Supplementation with High Dose Vitamin D3 Increases Serum Anti-Müllerian Hormone in Young Women

by
Nicola A. Dennis
1,
Lisa A. Houghton
2,
Michael W. Pankhurst
1,*,
Michelle J. Harper
2 and
Ian S. McLennan
1
1
Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand
2
Department of Human Nutrition, Division of Sciences, University of Otago, Dunedin 9054, New Zealand
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(7), 719; https://doi.org/10.3390/nu9070719
Submission received: 14 June 2017 / Revised: 3 July 2017 / Accepted: 4 July 2017 / Published: 8 July 2017

Abstract

Anti-Müllerian hormone (AMH) is a paracrine regulator of ovarian follicles. Vitamin D (Vit D) regulates AMH production in vitro, but its role as a regulator of ovarian AMH production is contentious. If Vit D influences ovarian AMH production, then an acute rise in Vit D level should lead to an acute rise in circulating AMH levels. This hypothesis was tested with a randomized double-blind design, with 18–25-year-old women recruited from the community. The study was conducted in early spring, when the marker of Vit D level (25-hydroxyvitamin D, 25(OH)D) tends to be at its nadir. The women consumed either an oral dose of 50,000 IU of Vit D3 (n = 27) or placebo (n = 22). The initial 25(OH)D ± SD value was 53.6 ± 23.3 nmol/L, with 42 of the 49 women having a value below 75 nmol/L, consistent with seasonal nadir. All women receiving Vit D3 treatment exhibited a robust increase in serum 25(OH)D within 1 day (15.8 ± 1.1 nmol/L (n = 27), p < 0.0001), with the increase sustained over the study week. Circulating levels of AMH in the women receiving Vit D3 progressively rose during the following week, with a mean increase of 12.9 ± 3.7% (n = 24, p = 0.001). The study supports the hypothesis that Vit D’s positive effects on the fertility of woman may involve the regulation of ovarian AMH levels.
Keywords: 25(OH)D; AMH; ovary; female reproduction 25(OH)D; AMH; ovary; female reproduction

Share and Cite

MDPI and ACS Style

Dennis, N.A.; Houghton, L.A.; Pankhurst, M.W.; Harper, M.J.; McLennan, I.S. Acute Supplementation with High Dose Vitamin D3 Increases Serum Anti-Müllerian Hormone in Young Women. Nutrients 2017, 9, 719. https://doi.org/10.3390/nu9070719

AMA Style

Dennis NA, Houghton LA, Pankhurst MW, Harper MJ, McLennan IS. Acute Supplementation with High Dose Vitamin D3 Increases Serum Anti-Müllerian Hormone in Young Women. Nutrients. 2017; 9(7):719. https://doi.org/10.3390/nu9070719

Chicago/Turabian Style

Dennis, Nicola A., Lisa A. Houghton, Michael W. Pankhurst, Michelle J. Harper, and Ian S. McLennan. 2017. "Acute Supplementation with High Dose Vitamin D3 Increases Serum Anti-Müllerian Hormone in Young Women" Nutrients 9, no. 7: 719. https://doi.org/10.3390/nu9070719

APA Style

Dennis, N. A., Houghton, L. A., Pankhurst, M. W., Harper, M. J., & McLennan, I. S. (2017). Acute Supplementation with High Dose Vitamin D3 Increases Serum Anti-Müllerian Hormone in Young Women. Nutrients, 9(7), 719. https://doi.org/10.3390/nu9070719

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop