The Effect of Buffering High Acid Load Meal with Sodium Bicarbonate on Postprandial Glucose Metabolism in Humans—A Randomized Placebo-Controlled Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Study Design and Randomization
2.3. Meal Study Procedures
2.4. Blood Pressure and Arterial Stiffness
2.5. Sample Collection and Analysis
2.6. Hunger and Satiety Assessment
2.7. Statistical Analysis
3. Results
3.1. Postprandial Acidity Markers with Sodium Bicarbonate or Placebo
3.2. Postprandial Glucose Regulation with Sodium Bicarbonate or Placebo
3.3. Satiety and Hunger with Sodium Bicarbonate or Placebo
3.4. Arterial Stiffness and Blood Pressure with Sodium Bicarbonate or Placebo
4. Discussion
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Constituent | Average Per Meal |
---|---|
Energy (kJ) | 3567 |
Protein (g) | 42 |
Fat (g) | 39 |
Saturated fat (g) | 18 |
Total carbohydrates (g) | 79 |
Sugar (g) | 31 |
Sodium (g) | 1.3 |
a PRAL (mEq) | 18.3 |
N (Men) | 30 (20) |
Age (years) | 31.5 (24.0–44.3) |
Waist circumference (cm) | 83.0 (77.0–91.0) |
Weight (kg) | 74.4 ± 14.9 |
BMI (kg/m2) | 24.0 (22.1–25.9) |
Family history of type 2 diabetes (n) | 10 |
Systolic blood pressure (mmHg) | 120 ± 12 |
Diastolic blood pressure (mmHg) | 77 ± 7 |
a Fasting blood glucose (mmol/L) | 4.6 ± 0.4 |
a Fasting serum insulin (mU/L) | 10.8 (8.0–17.3) |
a HOMA-IR | 2.3 (1.7–3.6) |
Serum creatinine (μmol/L) | 81.1 ± 10.1 |
a Fasting venous pH | 7.39 ± 0.02 |
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Kozan, P.; Blythe, J.C.; Greenfield, J.R.; Samocha-Bonet, D. The Effect of Buffering High Acid Load Meal with Sodium Bicarbonate on Postprandial Glucose Metabolism in Humans—A Randomized Placebo-Controlled Study. Nutrients 2017, 9, 861. https://doi.org/10.3390/nu9080861
Kozan P, Blythe JC, Greenfield JR, Samocha-Bonet D. The Effect of Buffering High Acid Load Meal with Sodium Bicarbonate on Postprandial Glucose Metabolism in Humans—A Randomized Placebo-Controlled Study. Nutrients. 2017; 9(8):861. https://doi.org/10.3390/nu9080861
Chicago/Turabian StyleKozan, Pinar, Jackson C. Blythe, Jerry R. Greenfield, and Dorit Samocha-Bonet. 2017. "The Effect of Buffering High Acid Load Meal with Sodium Bicarbonate on Postprandial Glucose Metabolism in Humans—A Randomized Placebo-Controlled Study" Nutrients 9, no. 8: 861. https://doi.org/10.3390/nu9080861