A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients
Abstract
:1. Introduction
2. Results
2.1. Processing and Characterization of the Newly Developed Adsorber Particle
2.2. Assessment of the Adsorption Capacity of the Particle towards Hydrophobic, Protein-Bound Uremic Toxins
2.3. Assessment of the Hemocompatibility of the Adsorber Particle
3. Discussion
4. Conclusions
5. Materials and Methods
5.1. Synthesis of the Particles
5.2. Microscopic Particle Characterization
5.3. Statement of Ethical Principles
5.4. Quantification of Adsorbed Hydrophobic Uremic Toxins by Analytical Reversed Phase Chromatography
5.5. Assessment of Hemocompatibility
5.6. Statistics
Author Contributions
Funding
Conflicts of Interest
References
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Sternkopf, M.; Thoröe-Boveleth, S.; Beck, T.; Oleschko, K.; Erlenkötter, A.; Tschulena, U.; Steppan, S.; Speer, T.; Goettsch, C.; Jankowski, V.; et al. A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients. Toxins 2019, 11, 389. https://doi.org/10.3390/toxins11070389
Sternkopf M, Thoröe-Boveleth S, Beck T, Oleschko K, Erlenkötter A, Tschulena U, Steppan S, Speer T, Goettsch C, Jankowski V, et al. A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients. Toxins. 2019; 11(7):389. https://doi.org/10.3390/toxins11070389
Chicago/Turabian StyleSternkopf, Marieke, Sven Thoröe-Boveleth, Tobias Beck, Kirsten Oleschko, Ansgar Erlenkötter, Ulrich Tschulena, Sonja Steppan, Thimoteus Speer, Claudia Goettsch, Vera Jankowski, and et al. 2019. "A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients" Toxins 11, no. 7: 389. https://doi.org/10.3390/toxins11070389