Dietary Fibre Intake Is Associated with Serum Levels of Uraemic Toxins in Children with Chronic Kidney Disease
Abstract
:1. Introduction
2. Results
3. Discussion
4. Conclusions
5. Materials and Methods
5.1. Study Population
5.2. Data Collection and Biochemical Measurements
5.3. Dietary Assessment
5.4. Statistical Analyses
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables | Values | |
---|---|---|
Demographics | ||
Age (years) | 9.3 ± 5.0 (1.0–18.0) | |
Gender: male | 44 (72) | |
Transplant recipients | 8 (13) | |
Anthropometry | ||
Weight SDS | −1.0 ± 1.4 | |
Height SDS | −1.2 ± 1.2 | |
BMI SDS | −0.3 ± 1.3 | |
BSA (m2) | 1.0 ± 0.4 | |
Cause of kidney failure | ||
Glomerular | 11 (18) | |
CAKUT | 27 (44) | |
Cystic disease | 6 (10) | |
Other non-glomerular | 17 (28) | |
Laboratory values | ||
eGFR (ml/min/1.73 m2) | 47.1 ± 28.9 | |
Chronic medication use | ||
Potassium binding resins | 7 (12) | |
Phosphate binders | 2 (3) | |
Iron supplements | 22 (36) | |
Immunosuppressive therapy | 10 (16) | |
Laxatives | 1 (3) | |
Antibiotics | 19 (31) | |
Nutrient intake | ||
Fibre intake (g/day/m2) | 12.6 ± 6.8 | |
%DRI fibre | 76.0 ± 36.0 | |
Protein intake (g/day/m2) | 54.4 ± 28.4 | |
%DRI protein | 220.1 ± 138.2 | |
Protein/fibre index | 4.3 (2.7–5.8) * | |
Energy (kCal/kg/day) | 59.8 ± 30.9 | |
Energy (kCal/day) | 1428.4 ± 504.9 | |
Gut-derived protein-bound uraemic toxins | ||
Free | Total | |
pCG (mg/dL) | 0.004 (0.001–0.013) | 0.006 (0.001–0.015) |
IAA (mg/dL) | 0.004 (0.002–0.007) | 0.042 (0.028–0.061) |
IxS (mg/dL) | 0.006 (0.003–0.015) | 0.247 (0.101–0.514) |
pCS (mg/dL) | 0.017 (0.006–0.034) | 0.761 (0.269–1.372) |
Gut-Derived Protein-Bound Uraemic Toxins (mg/dL) | Estimated Mean Ratio | Confidence Interval (CI) | p | |
---|---|---|---|---|
Lower 95% | Upper 95% | |||
pCG | ||||
Free concentration | ||||
Fibre intake (g/day) | 0.967 | 0.943 | 0.992 | 0.010 |
Protein intake (g/day) | 1.005 | 0.998 | 1.012 | 0.120 |
Total concentration | ||||
Fibre intake (g/day) | 0.970 | 0.944 | 0.995 | 0.021 |
Protein intake (g/day) | 1.006 | 0.998 | 1.012 | 0.116 |
IAA | ||||
Free concentration | ||||
Fibre intake (g/day) | 0.934 | 0.907 | 0.963 | <0.001 |
Protein intake (g/day) | 1.011 | 1.003 | 1.019 | 0.007 |
Total concentration | ||||
Fibre intake (g/day) | 0.984 | 0.971 | 0.997 | 0.020 |
Protein intake (g/day) | 1.001 | 0.998 | 1.005 | 0.430 |
IxS | ||||
Free concentration | ||||
Fibre intake (g/day) | 0.969 | 0.941 | 0.997 | 0.035 |
Protein intake (g/day) | 1.005 | 0.997 | 1.012 | 0.259 |
Total concentration | ||||
Fibre intake (g/day) | 0.986 | 0.965 | 1.006 | 0.196 |
Protein intake (g/day) | 1.001 | 0.996 | 1.007 | 0.645 |
pCS | ||||
Free concentration | ||||
Fibre intake (g/day) | 0.975 | 0.953 | 0.998 | 0.034 |
Protein intake (g/day) | 1.005 | 0.998 | 1.011 | 0.137 |
Total concentration | ||||
Fibre intake (g/day) | 0.984 | 0.956 | 1.011 | 0.261 |
Protein intake (g/day) | 1.004 | 0.9962 | 1.012 | 0.282 |
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El Amouri, A.; Snauwaert, E.; Foulon, A.; Vande Moortel, C.; Van Dyck, M.; Van Hoeck, K.; Godefroid, N.; Glorieux, G.; Van Biesen, W.; Vande Walle, J.; et al. Dietary Fibre Intake Is Associated with Serum Levels of Uraemic Toxins in Children with Chronic Kidney Disease. Toxins 2021, 13, 225. https://doi.org/10.3390/toxins13030225
El Amouri A, Snauwaert E, Foulon A, Vande Moortel C, Van Dyck M, Van Hoeck K, Godefroid N, Glorieux G, Van Biesen W, Vande Walle J, et al. Dietary Fibre Intake Is Associated with Serum Levels of Uraemic Toxins in Children with Chronic Kidney Disease. Toxins. 2021; 13(3):225. https://doi.org/10.3390/toxins13030225
Chicago/Turabian StyleEl Amouri, Amina, Evelien Snauwaert, Aurélie Foulon, Charlotte Vande Moortel, Maria Van Dyck, Koen Van Hoeck, Nathalie Godefroid, Griet Glorieux, Wim Van Biesen, Johan Vande Walle, and et al. 2021. "Dietary Fibre Intake Is Associated with Serum Levels of Uraemic Toxins in Children with Chronic Kidney Disease" Toxins 13, no. 3: 225. https://doi.org/10.3390/toxins13030225