Wearable Contact Lens Sensor for Non-Invasive Continuous Monitoring of Intraocular Pressure

Dou, Zhiqiang; Tang, Jun; Liu, Zhiduo; Sun, Qigong; Wang, Yang; Li, Yamin; Yuan, Miao; Wu, Huijuan; Wang, Yijun; Pei, Weihua; Chen, Hongda

doi:10.3390/mi12020108

Open AccessArticle

Wearable Contact Lens Sensor for Non-Invasive Continuous Monitoring of Intraocular Pressure

by

Zhiqiang Dou

^1,2

,

Jun Tang

^1,2,

Zhiduo Liu

^1,2,

Qigong Sun

^1,2,

Yang Wang

¹,

Yamin Li

^1,2,

Miao Yuan

^1,2,

Huijuan Wu

³,

Yijun Wang

^1,2,

Weihua Pei

^1,2,* and

Hongda Chen

^1,2

¹

The State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China

²

University of Chinese Academy of Sciences, Beijing 100049, China

³

Department of Ophthalmology, Peking University People’s Hospital, Beijing 100044, China

^*

Author to whom correspondence should be addressed.

Micromachines 2021, 12(2), 108; https://doi.org/10.3390/mi12020108

Submission received: 6 December 2020 / Revised: 18 January 2021 / Accepted: 19 January 2021 / Published: 22 January 2021

(This article belongs to the Special Issue Biosensors and MEMS-based Diagnostic Applications)

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Abstract

Intraocular pressure (IOP) is an essential indicator of the diagnosis and treatment of glaucoma. IOP has an apparent physiological rhythm, and it often reaches its peak value at night. To avoid missing the peak value at night and sample the entire rhythm cycle, the continuous monitoring of IOP is urgently needed. A wearable contact lens IOP sensor based on a platinum (Pt) strain gauge is fabricated by the micro-electro-mechanical (MEMS) process. The structure and parameters of the strain gauge are optimized to improve the sensitivity and temperature stability. Tests on an eyeball model indicate that the IOP sensor has a high sensitivity of 289.5 μV/mmHg and excellent dynamic cycling performance at different speeds of IOP variation. The temperature drift coefficient of the sensor is 33.4 μV/°C. The non-invasive IOP sensor proposed in this report exhibits high sensitivity and satisfactory stability, promising a potential in continuous IOP monitoring.

Keywords: IOP; glaucoma; wearable; strain gauge; MEMS; high sensitivity

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MDPI and ACS Style

Dou, Z.; Tang, J.; Liu, Z.; Sun, Q.; Wang, Y.; Li, Y.; Yuan, M.; Wu, H.; Wang, Y.; Pei, W.; et al. Wearable Contact Lens Sensor for Non-Invasive Continuous Monitoring of Intraocular Pressure. Micromachines 2021, 12, 108. https://doi.org/10.3390/mi12020108

AMA Style

Dou Z, Tang J, Liu Z, Sun Q, Wang Y, Li Y, Yuan M, Wu H, Wang Y, Pei W, et al. Wearable Contact Lens Sensor for Non-Invasive Continuous Monitoring of Intraocular Pressure. Micromachines. 2021; 12(2):108. https://doi.org/10.3390/mi12020108

Chicago/Turabian Style

Dou, Zhiqiang, Jun Tang, Zhiduo Liu, Qigong Sun, Yang Wang, Yamin Li, Miao Yuan, Huijuan Wu, Yijun Wang, Weihua Pei, and et al. 2021. "Wearable Contact Lens Sensor for Non-Invasive Continuous Monitoring of Intraocular Pressure" Micromachines 12, no. 2: 108. https://doi.org/10.3390/mi12020108

APA Style

Dou, Z., Tang, J., Liu, Z., Sun, Q., Wang, Y., Li, Y., Yuan, M., Wu, H., Wang, Y., Pei, W., & Chen, H. (2021). Wearable Contact Lens Sensor for Non-Invasive Continuous Monitoring of Intraocular Pressure. Micromachines, 12(2), 108. https://doi.org/10.3390/mi12020108

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Wearable Contact Lens Sensor for Non-Invasive Continuous Monitoring of Intraocular Pressure

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