Enhancing Flexible Neural Probe Performance via Platinum Deposition: Impedance Stability under Various Conditions and In Vivo Neural Signal Monitoring
Abstract
:1. Introduction
2. Materials and Methods
2.1. Platinum Deposition of the Neural Probe
2.2. SEM (Scanning Electron Microscopy) and EDS (Energy-Dispersive X-ray Spectroscopy) Analysis
2.3. Electrochemical Impedance Spectroscopy (EIS) Measurement
2.4. Mechanical Test
2.5. Thermal Test
2.6. Chemical Test
2.7. In Vivo Electrophysiological Recording
2.8. Whisker Stimulation
3. Results
3.1. Properties of Neural Probe
3.2. In Vivo Electrophysiological Recordings
4. Discussion
Neuropixels 2.0 | NeuroNexus SiNAPS | N32-1-b | |
---|---|---|---|
Channel | 5120 (1280 per shank) | 1024 (128 per shank) | 32 (8 for shank) |
Size (Electrode) | 12 μm × 12 μm (square) | 14 μm × 14 μm (square) | 20 μm (diameter) |
Impedance | ~150 kΩ (1.04 kΩ/μm2) | ~650 kΩ (3.32 kΩ/μm2) | ~152 kΩ (0.48 kΩ/μm2) |
Recording rate (Units per electrode) | 86% (1100/1280) | 25% (260/1024) | 59% (19/32) |
Durability (Units ratio) | 57% (638/1110) for 8 weeks | N/A | 55% (5/9) for 2 weeks |
Cost | USD 1400 | USD 1500 | USD 250 |
Flexibility | Rigid | Rigid | 500 times bending stable (R = 5 mm) |
Auxiliary device | Head stage, Holder | None | None |
Reference | [48,53] | [54] |
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Park, D.; Jeong, H.; Choi, J.; Han, J.; Piao, H.; Kim, J.; Park, S.; Song, M.; Kim, D.; Sung, J.; et al. Enhancing Flexible Neural Probe Performance via Platinum Deposition: Impedance Stability under Various Conditions and In Vivo Neural Signal Monitoring. Micromachines 2024, 15, 1058. https://doi.org/10.3390/mi15081058
Park D, Jeong H, Choi J, Han J, Piao H, Kim J, Park S, Song M, Kim D, Sung J, et al. Enhancing Flexible Neural Probe Performance via Platinum Deposition: Impedance Stability under Various Conditions and In Vivo Neural Signal Monitoring. Micromachines. 2024; 15(8):1058. https://doi.org/10.3390/mi15081058
Chicago/Turabian StylePark, Daerl, Hyeonyeong Jeong, Jungsik Choi, Juyeon Han, Honglin Piao, Jaehyun Kim, Seonghoon Park, Mingu Song, Dowoo Kim, Jaesuk Sung, and et al. 2024. "Enhancing Flexible Neural Probe Performance via Platinum Deposition: Impedance Stability under Various Conditions and In Vivo Neural Signal Monitoring" Micromachines 15, no. 8: 1058. https://doi.org/10.3390/mi15081058