Cancer Patients Have an Increased Incidence of Dementia: A Retrospective Cohort Study of 185,736 Outpatients in Germany
Abstract
:Simple Summary
Abstract
1. Introduction
2. Methods
2.1. Database
2.2. Study Population
2.3. Study Outcomes and Covariates
2.4. Statistical Analyses
3. Results
3.1. Basic Characteristics of Study Cohort
3.2. Incidence Rates of Dementia Are Higher in Cancer Patients
3.3. Subgroup Analysis of Demographic Aspects and Tumor Entities
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable | Proportion Affected among Patients with Cancer (%) n = 92,868 | Proportion Affected among Patients without Cancer (%) n = 92,868 | p-Value |
---|---|---|---|
Age (mean, SD) | 74.8 (6.4) | 74.8 (6.4) | 1.000 |
Age 65–70 | 29.6 | 29.6 | 1.000 |
Age 71–75 | 27.2 | 27.2 | |
Age 76–80 | 23.6 | 23.6 | |
Age 81–85 | 13.3 | 13.3 | |
Age >85 | 6.3 | 6.3 | |
Women | 47.9 | 47.9 | 1.000 |
Men | 52.1 | 52.1 | |
Number of visits per year during the follow-up time | 6.8 (6.2) | 6.8 (6.2) | 1.000 |
Comorbidities documented within 12 months prior to index date | |||
Diabetes | 30.2 | 34.1 | <0.001 |
Obesity | 11.6 | 12.3 | <0.001 |
Hypertension | 69.7 | 72.0 | <0.001 |
Lipid metabolism disorders | 46.7 | 47.6 | <0.001 |
Peripheral artery disease | 8.0 | 8.2 | 0.039 |
Myocardial infarction | 3.5 | 3.6 | 0.033 |
Stroke including TIA | 7.4 | 8.0 | <0.001 |
Depression | 17.2 | 17.8 | 0.004 |
Osteoporosis | 11.7 | 11.3 | 0.009 |
Variable | Hazard Ratio (95% CI) * | p-Value |
---|---|---|
Total (n = 92,868 pairs) | 1.30 (1.27–1.34) | <0.001 |
Age 65–70 (n = 27,484 pairs) | 1.33 (1.24–1.43) | <0.001 |
Age 71–75 (n = 25,221 pairs) | 1.31 (1.24–1.39) | <0.001 |
Age 76–80 (n = 21,958 pairs) | 1.26 (1.20–1.33) | <0.001 |
Age 81–85 (n = 12,326 pairs) | 1.25 (1.17–1.33) | <0.001 |
Age >85 (n = 5879 pairs) | 1.30 (1.19–1.42) | <0.001 |
Female patients (n = 44,461 pairs) | 1.26 (1.21–1.31) | <0.001 |
Male patients (n = 48,407 pairs) | 1.35 (1.30–1.41) | <0.001 |
Breast cancer (women) (n = 11,708 pairs) | 1.23 (1.15–1.31) | <0.001 |
Prostate cancer (men) (n = 14,001 pairs) | 1.27 (1.20–1.35) | <0.001 |
Skin cancer (n = 21,716 pairs) | 1,29 (1.24–1.35) | <0.001 |
Lung cancer (n = 3500 pairs) | 1.44 (1.28–1.62) | <0.001 |
Digestive organ cancer (n = 14,340 pairs) | 1.28 (1.22–1.35) | <0.001 |
Lymphoid and haematopoietic tissue cancer (n = 6369 pairs) | 1.24 (1.14–1.34) | <0.001 |
Urinary tract cancer (n = 7290 pairs) | 1.24 81.15–1.33) | <0.001 |
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Roderburg, C.; Loosen, S.H.; Kunstein, A.; Mohr, R.; Jördens, M.S.; Luedde, M.; Kostev, K.; Luedde, T. Cancer Patients Have an Increased Incidence of Dementia: A Retrospective Cohort Study of 185,736 Outpatients in Germany. Cancers 2021, 13, 2027. https://doi.org/10.3390/cancers13092027
Roderburg C, Loosen SH, Kunstein A, Mohr R, Jördens MS, Luedde M, Kostev K, Luedde T. Cancer Patients Have an Increased Incidence of Dementia: A Retrospective Cohort Study of 185,736 Outpatients in Germany. Cancers. 2021; 13(9):2027. https://doi.org/10.3390/cancers13092027
Chicago/Turabian StyleRoderburg, Christoph, Sven H. Loosen, Anselm Kunstein, Raphael Mohr, Markus S. Jördens, Mark Luedde, Karel Kostev, and Tom Luedde. 2021. "Cancer Patients Have an Increased Incidence of Dementia: A Retrospective Cohort Study of 185,736 Outpatients in Germany" Cancers 13, no. 9: 2027. https://doi.org/10.3390/cancers13092027