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Article

Baeyer-Villiger-Including Domino Two-Step Oxidations of β-O-Substituted Primary Alcohols: Reflection of the Migratory Aptitudes of O-Substituted Alkyl Group in the Outcome of the Reaction

by
Tom Targel
and
Moshe Portnoy
*
School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 6997801, Israel
*
Author to whom correspondence should be addressed.
Catalysts 2020, 10(11), 1275; https://doi.org/10.3390/catal10111275
Submission received: 15 October 2020 / Revised: 29 October 2020 / Accepted: 30 October 2020 / Published: 3 November 2020
(This article belongs to the Special Issue Organocatalysis: Advances, Opportunity, and Challenges)
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Abstract

:
Following the recent development of the one-pot two-step oxidation protocol for primary β-alkoxy alcohols, additional primary β-oxy alcohols were examined under similar conditions. The outcome of these reactions closely follows the migratory aptitudes of the related α-oxy-alkyls in Baeyer-Villiger oxidation vs. that of hydrogen. Thus, these experiments helped to establish the correct order of these aptitudes for α-oxy-alkyls. Furthermore, in the case of primary β,β-dialkoxyalcohols, the formation of dialkoxymethyl formates by the domino oxidation reaction was followed by secondary reactions, forming a number of interesting products.

Graphical Abstract

1. Introduction

Oxidation of secondary alcohols usually leads to ketones as end products [1], and only the Baeyer-Villiger (BV) reaction [2,3,4,5], inserting oxygen between the carbonyl and an adjacent carbon and, thus, forming an ester with an interrupted carbon skeleton, could lead to an additional oxidation completing a two-step oxidation sequence [6,7,8,9,10,11,12,13,14,15,16,17,18,19]. In the case of the primary alcohols, two-stage oxidation is much more common and leads predominantly to carboxylic acids [20], which are formed from aldehydes via the Baeyer-Villiger pathway or one of the alternative mechanisms at the second step. Only rarely, in the case of electron-rich benzaldehydes or aldehydes with a nitrogen- or an oxygen-substituted α-carbon, BV oxidation of aldehydes results in the opposite regioselectivity, leading to hemiacetal formates [21,22,23,24,25,26,27,28,29,30,31]. Surprisingly, prior to our work only scarce examples of two-step BV-involving oxidation of primary alcohols to esters in two successive, but separate steps, were reported [28,29,30,31], while such one-pot oxidations have never been explored. Recently, we reported an unprecedented and efficient one-pot procedure for transformation of primary β-alkoxy alcohols into the corresponding hemiacetal formates [32]. Similarly, secondary β-alkoxy alcohols can be converted in a one-pot fashion into hemiacetal esters [33]. This process, combining TEMPO-based catalytic and mCPBA-induced stoichiometric steps (Scheme 1a, TEMPO = (2,2,6,6-tetramethylpiperidin-1-yl)oxyl, mCPBA = m-chloroperbenzoic acid), reflects the stronger migratory aptitude of alkoxyalkyls compared to that of hydrogen or simple alkyl in the BV step.
While attempting to expand the new methodology to additional types of substrates we found that the regioselectivity of the BV step is strongly dependent on the nature of the oxy-substituent on the α-to-carbonyl carbon. Thus, β-acyloxy alcohols yielded carboxylic acids, while γ-alkoxy-β-hydroxyalcohols formed transient gem-diol monoesters, which underwent an additional oxidation step after eliminating formic acid (Scheme 1b,c). Obviously, the course of the domino reaction and, particularly, of the second (Baeyer-Villiger) step reflects the migratory aptitudes of various α-O-substituted alkyl groups. It occurred to us that the reaction enables easy comparison of these aptitudes with that of hydrogen as the reference point [34] (Scheme 2).
With this notion in mind, we turned to study the reaction of other types of β-O-substituted primary alcohols under the abovementioned one-pot reaction conditions, aiming both to expand the scope of the reaction and compare the migratory aptitudes of additional oxyalkyl groups in BV oxidation. Herein we describe the results of these studies.

2. Results and Discussion

Our previous experiments already demonstrated the following order of migratory aptitudes: α-acyloxyalkyl < H < α-alkoxyalkyl. The position of α-hydroxyalkyl should be to the right of H in this series, in line with the abovementioned formation of transient gem-diol monoesters from β-hydroxy alcohols. Furthermore, the course of the reaction of 1,4-anhydroerythritol (a secondary alcohol, Scheme 3) hints that the migratory aptitude of α-hydroxyalkyl is stronger than that of α-alkoxyalkyl [32,35].
The position of some other oxyalkyl groups in the series describing their migratory aptitudes remained, however, unclear. Accordingly, we tested a number of additional primary alcohol substrates in the domino oxidation reaction (Table 1). 2-phenoxyethanol (1a), for instance, exhibited slow conversion into both the corresponding hemiacetal formate 2a and the corresponding carboxylic acid 3a [36] (entry 1). In order to achieve full consumption of the starting material, the TEMPO/TBAB loading should be increased to 5 molar %, while that of mCPBA to 6.6 equiv. Under these conditions, a ratio of 1:0.4 between the hemiacetal formate product and the carboxylic acid product is achieved. This ratio, as well as the reaction rate, indicate that though the propensity of phenoxymethyl to migrate during the BV reaction is stronger than that of hydrogen, it is so only by a relatively small margin.
Subsequently, we decided to examine primary alcohols substituted at the β-position with a single acetal oxygen (i.e., by alkoxyalkoxy group, entries 2–4). When substrates 1b and 1c were subjected to the reaction conditions [37], the corresponding carboxylic acids 3b and 3c were invariably formed as sole products. In the case of similarly substituted 1d, a mixture of products, with carboxylic acid 3d being the major product, was produced. Four additional minor products are two diastereomeric pairs of hemiacetal esters, formates and m-chlorobenzoates, presumably derived from a single hemiacetal formate product 2d (Scheme 4). The overall ratio between 3d and 2d-derived products was 6.7:1. The results of the experiments with alcohols 1b–d demonstrate that the migratory aptitude of alkyls substituted by a single acetal oxygen is lower than that of hydrogen, but probably higher than that of acyloxyalkyls. Furthermore, the substrates of this kind cannot be successfully converted into hemiacetal esters under our domino reaction conditions.
The next type of substrates we wanted to examine were primary alcohols with an acetal carbon as the β-carbon (i.e., with the β-carbon substituted by two alkoxy groups). Three compounds of this type, 1e–g, were prepared (Scheme 5) and examined under standard domino reaction conditions (Table 1, Entries 5–7). If such a substrate undergoes the reaction in a mode similar to that of β-alkoxy alcohols, one may expect generation of 2-formyloxy-1,3-dioxolane or -dioxane products 2e–g (Scheme 6). While rare, such dialkoxymethyl carboxylates are not unprecedented [38]. However, such formates are particularly unstable and, accordingly, under the reaction conditions, their subsequent hydrolytic decomposition is possible. Indeed, diol mono-formate esters 4e,f were identified as the major products of the reaction of substrates 1e,f, presumably via 2-step hydrolysis of 2e,f (Scheme 6). In the reaction mixture of 1e, minor products 5e–1 and 5e–2, presumably resulting from interception of one of the hydrolysis intermediates by the substrate or the major product, were observed. In the case of substrate 1g, diol mono-formate 4g constitutes the minor product of the reaction, while the major product was identified as the cyclic carbonate 5g, likely formed by an additional TEMPO-catalyzed oxidation of one of the hydrolytic intermediates (Scheme 6) [39]. These results prove that β,β-dialkoxy alcohols react in the domino oxidation reaction in a way similar to β-alkoxy alcohols, but form unstable products. Furthermore, it demonstrated that the migratory aptitude of the α,α-dialkoxymethyl in the BV reaction is higher than that of hydrogen. Finally, these experiments demonstrated selective formation of diol monoesters from diols by their conversion to hydroxyacetaldehyde-derived acetals, followed by the domino oxidation–hydrolysis sequence.
In order to compare the aptitudes of α,α-dialkoxyalkyl and α-alkoxyalkyl, we examined the reaction of a secondary alcohol 1h with both groups flanking the hydroxyl-bearing carbon (Table 1, Entry 8). In this experiment the formation of product 2h, generated by oxidation of the secondary alcohol followed by the oxygen insertion between the formed carbonyl and the alkoxy-substituted neighboring carbon, indicates that the migratory tendency of α-alkoxyalkyl is stronger (in the BV reaction).
Another aspect that was examined during our experiments is the influence of the solvent on the domino reaction course. We focused our attention on two substrates, which in DCM gave both the hemiacetal formate and the carboxylic acid products, namely Bz(OCH2CH2)2OH (1i) that was reported in our previous communication and 1d (Table 2). Three solvents, apolar benzene, moderately polar ethyl acetate and polar acetonitrile, were compared to the originally used DCM. In both cases the best solvent for the formation of hemiacetal esters was benzene, while acetonitrile, the most polar of the three solvents, most favored the formation of carboxylic acid. Lower conversions observed in ethyl acetate are attributed to the absence of TBAB in these experiments due to its insolubility in this solvent. In the past, similar solvent dependence was observed in oxidation of aldehyde by dioxygen or peracids, with the increase in acid formation attributed to the disruption of the transition state, preferentially leading to acetal formates, by polar solvents [40]. Interestingly, the opposite trend was observed in aqueous organic solvents in the related Dakin reaction [41].

3. Materials and Methods

3.1. Materials and Techniques

All reactions, requiring anhydrous conditions, were conducted under an atmosphere of nitrogen in oven-dried glassware in dry solvents. Commercially available materials were purchased at the highest available purity and were used as received. Thin layer chromatography (TLC) was performed on silica gel plates Merck 60 F254, and the compounds were visualized by irradiation with UV light or by staining with KMnO4. Flash column chromatography was carried out using silica gel Merck 60 (particle size 0.040–0.063 mm); the eluent is given in parentheses. 1H NMR (400 MHz) and 13C NMR (100 MHz) spectra were recorded on Bruker AVANCE-400 spectrometers, in DMSO-d6 with residual DMSO-d5 (1H, 2.50 ppm) or DMSO-d6 (13C, 39.52 ppm) as an internal shift calibration standard; or in CDCl3 with residual CHCl3 (1H, 7.26 ppm) or CDCl3 (13C, 77.16 ppm) as an internal shift calibration standard. MS analyses were conducted on Waters SYNAPT instrument. (See the Supplementary Materials) IR spectra were recorded on Bruker Tensor 27 with Platinum ATR.

3.2. Synthesis of Substrates

3.2.1. Synthesis of [(2S,4S)-2-Phenyl-1,3-Dioxan-4-yl]Methanol (1b):

A solution of (S)-1,2,4-butanetriol (531 mg, 5.0 mmol, 1.0 equiv), benzaldehyde dimethyl acetal (841 mg, 5.5 mmol, 1.1 equiv) and camphorsulfonic acid (59 mg, 0.25 mmol, 5 mol%) in CH2Cl2 (21 mL) was stirred at room temperature for 20 h. Imidazole was added in one portion (34 mg, 0.5 mmol, 0.1 equiv) and the resulting mixture was concentrated in vacuo. The residue was purified by flash chromatography (silica gel, 1:3 to 3:1 EtOAc/hexane) to yield the product as a colorless oil (399 mg, 41%) [42].
TLC: Rf = 0.4 (3:1 EtOAc/hexane eluent). 1H-NMR (400 MHz, CDCl3) δ 7.51-7.48 (dd, J = 7.6, 1.8 Hz, 2H), 7.40-7.33 (m, 3H), 5.55 (s, 1H), 4.30 (ddd, J = 11.4, 5.1, 1.2 Hz, 1H), 4.04-3.98 (m, 1H), superimposed by 4.02-3.95 (td, J = 11.9, 2.4 Hz, 1H), 3.73-3.62 (m, 2H), 2.16 (t, J = 6.3 Hz, 1H), 1.98-1.87 (qd, J = 12.4, 5.2 Hz, 1H), 1.47-1.43 (dtd, J = 13.2, 2.5 Hz, 1.4 Hz, 1H). 13C-NMR (100 MHz, CDCl3): δ 138.5, 129.1, 128.4, 126.2, 101.4, 77.7, 66.7, 65.8, 26.9.

3.2.2. Synthesis of (5,5-Dimethyl-1,3-Dioxan-2-yl)Methanol (1e):

2-((benzyloxy)methyl)-5,5-dimethyl-1,3-dioxane [43]: In a round-bottom flask equipped with a Dean-Stark apparatus, a water-cooled condenser and a magnetic stir bar, benzyloxyacetaldehyde (760 mg, 1.0 equiv, 5.06 mmol), 2.2-dimethyl-1,3-propanediol (633 mg, 1.2 equiv, 6.07 mmol) and p-toluenesulfonic acid monohydrate (43 mg, 0.23 mmol, 4.5 mol %) were dissolved in toluene (2 mL), refluxed for 4 h, and were subsequently cooled to room temperature. Triethylamine (0.6 mL, 0.85 equiv, 4.3 mmol) was added and the solvent was removed under reduced pressure. The residue was purified using column chromatography (silica gel, 1:9 EtOAc/hexane) to give the desired product (835 mg, 3.53 mmol, 70% yield) as a colorless oil.
TLC: Rf = 0.3 (1:9 EtOAc/hexane eluent). 1H-NMR (400 MHz, CDCl3): δ 7.31 (m, 5H), 4.66 (t, J = 4.6 Hz, 1H), 4.60 (s, 2H), 3.64 (d, J = 11.2 Hz, 2H), 3.55 (d, J = 4.6 Hz, 2H), 3.45 (d, J = 10.7 Hz, 2H), 1.20 (s, 3H), 0.73 (s, 3H). 13C-NMR (100 MHz, CDCl3): δ 137.9, 128.5, 128.1, 127.9, 100.2, 77.20, 73.8, 71.4, 30.5, 23.1, 22.0.
(5,5-dimethyl-1,3-dioxan-2-yl)methanol (1e) [43]: 2-((benzyloxy)methyl)-5,5-dimethyl-1,3-dioxane (800 mg, 3.38 mmol) was dissolved in methanol (5 mL) in a round-bottom flask equipped with a magnetic stir bar. A small spoonful of 5% Pd/C was added, and a hydrogen-filled balloon was attached to the flask via a suitable adapter. After flushing the flask with hydrogen a few times, the mixture was allowed to stir overnight at room temperature. The mixture was then filtered through celite and the resulting clear solution was concentrated under reduced pressure to give the desired product (470 mg, 3.21 mmol, 95% yield) as a colorless oil, which was used without further purification.
1H-NMR (400 MHz, CDCl3): δ 4.54 (t, J = 4.4 Hz, 1H), 3.64 (m, 4H), 3.47 (d, J = 10.6 Hz, 2H), 1.93 (t, J = 6.6 Hz, 1H), 1.19 (s, 3H), 0.74 (s, 3H). 13C-NMR (100 MHz, CDCl3): δ 100.5, 77.1, 64.1, 30.6, 23.0, 21.9.

3.2.3. Synthesis of ((3ar,9as)-3a,4,9,9a-Tetrahydronaphtho[2,3-d][1,3]dioxol-2-yl)methanol (1f)

(2R,3S)-1,2,3,4-tetrahydronaphthalene-2,3-diol [44]: 1,4-dihydronapthalene (326 mg, 2.50 mmol, 1.0 equiv), NMO (590 mg, 5.04 mmol, 2 equiv) and OsO4 (4% w/w in water, 0.12 mL, 0.02 mmol, 0.8 mol %) were dissolved in a mixture of 3.5 mL acetone, 3.5 mL of water and 0.35 mL of tBuOH in a vial charged with a magnetic stir bar. The mixture was allowed to stir and was monitored by TLC every half an hour until no more starting material was observed, after an hour and a half. The solvent mixture was removed under reduced pressure, and the crude was purified by column chromatography (silica gel, 1:3 EtOAc/hexane to EtOAc) to give the desired product (253 mg, 1.53 mmol, 61% yield) as a colorless liquid.
TLC: Rf = 0.3 (9:1 EtOAc/hexane eluent). 1H-NMR (400 MHz, CDCl3): δ 7.11 (m, 4H), 4.11 (t, J = 5.2 Hz, 2H), 3.01 (m, 4H), 2.45 (s, 2H). 13C-NMR (100 MHz, CDCl3): δ 133.0, 129.3, 126.4, 69.4, 34.5.
(3aR,9aS)-2-((Benzyloxy)methyl)-3a,4,9,9a-Tetrahydronaphtho[2,3-d][1,3]dioxole: The abovementioned diol (202 mg, 1.23 mmol, 1.0 equiv) and 2-(benzyloxy)acetaldehyde (181 mg, 1.21 mmol, 0.98 equiv) were dissolved in toluene (2 mL) in a vial charged with a magnetic stir bar, connected to a Dean-Stark apparatus. TsOH (11.4 mg, 0.06 mmol, 5 mol %) was added and the mixture was allowed to stir for 3.5 h. TEA (0.15 mL) was added, and the mixture was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 1:9 to 1:4 EtOAc/hexane) to give a 1:0.35 diastereomeric mixture of the desired product (231 mg, 0.78 mmol, 63% yield) as a yellow oil.
TLC: Rf = 0.3 (1:4 EtOAc/hexane eluent).
Major diastereoisomer: 1H-NMR (400 MHz, CDCl3): δ 7.23-7.34 (m, 5H), 7.14-7.20 (m, 4H), 5.00 (t, J = 4.1 Hz, 1H), 4.50 (m, 2H), 4.44 (s, 2H), 3.30 (d, J = 4.1 Hz, 2H), 2.93 (ddd, J = 15.1, 2.9, 1.5 Hz, 2H), 2.81 (ddd, J = 15.0, 3.0, 1.6 Hz, 2H). 13C-NMR (100 MHz, CDCl3): δ 138.0, 135.1, 128.4 (2C), 127.9, 127.7, 126.8, 101.8, 75.2, 73.6, 70.6, 33.9.
Minor diastereoisomer: 1H-NMR (400 MHz, CDCl3): δ 7.23-7.34 (m, 5H), 7.14-7.20 (m, 4H), 4.95 (t, J = 3.9 Hz, 1H), 4.68 (m, 2H), 4.56 (s, 2H), 3.43 (d, J = 3.9 Hz, 2H), 2.97 (ddd, J = 14.9, 3.0, 1.4 Hz, 2H), 2.83 (ddd, J = 15.0, 3.0, 1.6 Hz, 2H). 13C-NMR (100 MHz, CDCl3): δ 138.0, 135.3, 128.5, 128.3, 127.9, 127.8, 127.0, 102.7, 75.3, 73.8, 71.3, 34.2.
IR (neat) ν 2912, 1456, 1110, 751 cm−1. HRMS (AP+/TOF) m/z: calcd for C19H19O3 ([M-H]+) 295.1334; found 295.1338.
((3aR,9aS)-3a,4,9,9a-Tetrahydronaphtho[2,3-d][1,3]dioxol-2-yl)methanol (1f): The abovementioned diastereomeric mixture (216 mg, 0.73 mmol, 1.0 equiv) was dissolved in methanol (2.5 mL). A small spoon of activated 10% Pd/C was added to it in a round-bottom flask charged with a magnetic stir bar, a hydrogen balloon was attached and the mixture was allowed to stir for 24 h at room temperature. The resulting solution was filtered through celite and concentrated under reduced pressure to give a 1:0.4 diastereomeric mixture of 1f (138 mg, 0.67 mmol, 91% yield) as a yellow liquid, which was used in the next step without further purification.
Major diastereoisomer: 1H-NMR (400 MHz, CDCl3): δ 7.20 (m, 4H), 4.91 (t, J = 2.4 Hz, 1H), 4.60 (m, 2H), 3.46 (s, 2H), 3.00 (m, 2H), 2.76 (m, 2H). 13C-NMR (100 MHz, CDCl3): δ 134.8, 128.5, 127.1, 101.7, 75.2, 62.0, 33.7.
Minor diastereoisomer: 1H-NMR (400 MHz, CDCl3): δ 7.20 (m, 4H), 4.76 (t, J = 3.4 Hz, 1H), 4.71 (m, 2H), 3.51 (d, J = 3.0 Hz, 2H), 3.00 (m, 2H), 2.83 (m, 2H). 13C-NMR (100 MHz, CDCl3): δ 135.2, 128.3, 127.1, 103.3, 75.5, 63.1, 34.3.
IR (neat) ν 3422, 2916, 1458, 1137, 1049, 750 cm−1. HRMS (ES+/TOF) m/z: calcd for C12H14O3Na ([M + Na]+) 229.0841; found 229.0835.

3.2.4. Synthesis of (4,4,5,5-Tetramethyl-1,3-dioxolan-2-yl)methanol (1g):

2-((benzyloxy)methyl)-4,4,5,5-tetramethyl-1,3-dioxolane: Pinacol (718 mg, 6.07 mmol, 1.2 equiv) and 2-(benzyloxy)acetaldehyde (760 mg, 5.06 mmol, 1.0 equiv) were dissolved in toluene (10 mL) in a round-bottom flask, equipped with a Dean-Stark apparatus and charged with a magnetic stir bar. TsOH (48 mg, 0.25 mmol, 5 mol %) was added and the mixture was allowed to stir overnight. TEA (0.50 mL) was added, and the mixture was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 1:19 to 1:4 EtOAc/hexane) to give the desired product (870 mg, 3.48 mmol, 68.8% yield) as a yellow oil.
TLC: Rf = 0.35 (1:4 EtOAc/hexane eluent). 1H-NMR (400 MHz, CDCl3): δ 7.24-7.37 (m, 5H), 5.19 (t, J = 4.5Hz, 1H), 4.61 (s, 2H), 3.49 (d, J = 4.5Hz, 2H), 1.21 (s, 6H), 1.20 (s, 6H). 13C-NMR (100 MHz, CDCl3): δ 138.2, 128.4, 128.0, 127.7, 99.2, 82.2, 73.7, 72.7, 24.0, 22.1. IR (neat) ν 2978, 2865, 1454, 1367, 1156, 1105, 733, 697 cm−1. HRMS (ES+/TOF) m/z: calcd for C15H21O3 ([M-H]+) 249.1491; found 249.1494.
(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)methanol (1g): The abovementioned protected alcohol (870 mg, 3.48 mmol, 1 equiv) was dissolved in methanol. A spoon of activated 10% Pd/C was added to a vial charged with a magnetic stir bar, a hydrogen balloon was attached and the mixture was allowed to stir for 24 h at room temperature. The resulting solution was filtered through celite and concentrated under reduced pressure to give 1g (260 mg, 1.62 mmol, 47% yield) as a yellow oil, which was used in the next step without further purification.
1H-NMR (400 MHz, CDCl3): δ 5.09 (t, J = 3.9 Hz, 1H), 3.60 (dd, J = 6.5, 3.9 Hz, 2H), 1.96 (t, J = 6.6 Hz,1H), 1.22 (s, 6H), 1.21 (s, 6H). 13C-NMR (100 MHz, CDCl3): δ 99.6, 82.5, 64.9, 24.2, 22.2. IR (neat) ν 3446, 2978, 2875, 1447, 1368, 1153, 1054, 889 cm−1. HRMS (ES+/TOF) m/z: calcd for C8H16O3Na ([M + Na+]+) 183.0997; Found 183.1003.

3.3. Oxidations and Characterization of Products

3.3.1. Typical Procedure for TEMPO/mCPBA Oxidation:

The substrate (1.0 equiv, 0.1 mmol) was placed in a small vial charged with a magnetic stir bar, and the solutions of TEMPO (0.1 M, 20–50 µL, 2–5 molar %) and TBAB (0.1 M, 20–50 µL, 2–5 molar %) were added by syringe at room temperature. mCPBA (2.2–6.6 equiv.) solution in 0.70–0.76 mL DCM was added, resulting in a total volume of 0.80 mL DCM, and the reaction was allowed to stir for 1 to 17 h, depending on the substrate. In some cases, the solvent was removed under reduced pressure, and the crude reaction mixture was analyzed by NMR spectroscopy in DMSO-d6. In other cases, aqueous saturated NaHCO3 solution (5.0 mL) was added, the mixture was stirred for 5 min, the organic phase was separated, and the aqueous phase was extracted with DCM (4 × 2.5 mL). Subsequently, the combined organic phase was washed with brine (5 mL), dried over Na2SO4, filtered, concentrated in vacuo, and the crude was analyzed by NMR spectroscopy.

3.3.2. Oxidation of 2-Phenoxyethan-2-ol (1a):

Commercially available 1a (138 mg, 1.0 equiv, 1.0 mmol) was oxidized according to the general procedure outlined above, scaled-up by ten (5 mol % TEMPO, 5 mol % TBAB, 3.3 equiv. mCPBA, 3 h reaction time), including the workup sequence. Purification by column chromatography (silica gel, 1–5% EtOAc/hexane) gave 2a (23 mg, 0.15 mmol, 15% yield) as a yellow oil.
TLC: Rf = 0.3 (5% EtOAc/hexane eluent). 1H NMR (400 MHz, CDCl3): δ 8.14 (s, 1H), 7.33 (m, 2H), 7.07 (m, 3H), 7.45 (m, 2H), 5.86 (s, 2H). 13C NMR (100 MHz, CDCl3): δ 159.9, 156.7, 129.8, 123.2, 116.2, 85.4. IR (neat) ν 2924, 1732, 1597, 1494, 1213, 1048, 946, 750, 691 cm−1. HRMS (EI+) m/z: calcd for C8H8O3 (M+) 152.0473; found 152.0471.

3.3.3. Oxidation of [(2S,4S)-2-Phenyl-1,3-dioxan-4-yl]methanol (1b):

1b (97 mg, 1.0 equiv, 0.5 mmol) was oxidized according to the general procedure outlined above, scaled-up by five (2 mol % TEMPO, 2 mol % TBAB, 2.2 equiv. mCPBA), excluding the workup sequence. After overnight stirring, the reaction mixture was directly loaded to a silica gel column and purified (1:1 EtOAc/hexane to EtOAc, followed by 1:9 to 1:4 MeOH/EtOAc) to give 3b (19 mg, 0.09 mmol, 18% yield) as a colorless solid [45].
TLC: Rf = 0.25 (1:4 MeOH/EtOAc eluent). 1H-NMR (400 MHz, methanol-d4) δ 7.54-7.51 (m, 2H), 7.37-7.32 (m, 3H), 5.59 (s, 1H), 4.47-4.44 (dd, J = 11.4, 3.0 Hz, 1H), 4.29-4.25 (ddd, J = 11.4, 4.8, 1.2 Hz, 1H), 4.08-4.02 (td, J = 11.7, 2.9 Hz, 1H), 2.02-1.90 (m, 2H). 13C-NMR (100 MHz, methanol-d4): δ 176.0, 139.8, 129.8, 129.0, 127.5, 102.4, 77.6, 68.1, 29.9. HRMS (ES−/TOF) m/z: calcd for C11H11O4 ([M-H]−) 207.0657; found 207.0659.

3.3.4. Oxidation of (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triyl tribenzoate (1c):

Commercially available 1c (51 mg, 1.0 equiv, 0.1 mmol) was oxidized according to the general procedure outlined above (2 mol % TEMPO, 2 mol % TBAB, 2.2 equiv. mCPBA, 3 h reaction time), including the workup sequence. The product 3c was characterized from the crude reaction mixture without purification [46].
1H-NMR (400 MHz, DMSO-d6): δ 7.85 (d, J = 7.0, 2H), 7.84 (d, J = 7.0 Hz, 2H), 7.77 (d, J = 7.4 Hz, 2H), 7.59 (t, J = 7.4 Hz, 1H), 7.56 (t, J = 7.4 Hz, 1H), 7.52 (t, J = 7.9 Hz, 1H), 7.45 (t, J = 7.7 Hz, 2H), 7.42 (t, J = 7.7 Hz, 2H), 7.37 (t, J = 7.7 Hz, 2H), 5.89 (t, J = 9.7 Hz, 1H), 5.67 (t, J = 9.7 Hz, 1H), 5.41 (dd, J = 10.0, 3.4 Hz 1H), 5.26 (d, J = 3.3 Hz, 1H), 4.17 (d, J = 10.0 Hz, 1H), 3.43 (s, 3H). 13C-NMR (100 MHz, DMSO-d6): δ 169.1, 165.0, 164.7, 164.2, 133.1, 132.8, 132.4, 129.6, 128.80, 128.76, 128.73, 128.61, 128.55, 128.2, 128.0, 127.9, 96.2, 71.1, 70.7, 70.2, 54.8, 54.2. HRMS (ES−/TOF) m/z: calcd for C28H23O10 ([M-H]−) 519.1291; found 519.1289.

3.3.5. Oxidation of (4R-cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester (1d):

Commercially available 1d (26 mg, 1.0 equiv, 0.1 mmol) was oxidized according to the general procedure outlined above (5 mol % TEMPO, 5 mol % TBAB, 2.2 equiv. mCPBA, 3 h reaction time), using benzene as the solvent and excluding the work-up sequence. The crude mixture was analyzed by NMR and was found to contain a 1:4.9 mixture of 2d and 3d [47]. Determination of C was done using an overlapping spectrum of the pure starting material, the pure acid, the abovementioned 1:4.9 mixture, and TBAB.
2d: Partial 1H-NMR (400 MHz, DMSO-d6): δ 8.28 (s, 1H), 6.14 (dd, J = 9.6, 3.0 Hz, 1H), 4.31 (m, 1H), 1.88 (dt, J = 12.4, 3.0 Hz, 1H). 13C-NMR (100 MHz, DMSO-d6): δ 169.2, 161.2, 100.0, 89.2, 79.9, 65.2, 64.1, 41.6, 37.1, 34.4, 29.5, 20.7.
3d: 1H-NMR (400 MHz, DMSO-d6): δ 4.47 (dd, J = 11.9, 2.4 Hz, 1H), 4.26 (m, 1H), 2.40 (dd, J = 15.1, 4.7 Hz, 1H), 2.23 (dd, J = 15.2, 8.1 Hz, 1H), 1.80 (dt, J = 12.8, 2.3 Hz, 1H), 1.40 (s, 3H), 1.37 (s, 9H), 1.32 (m, 1H), 1.28 (s, 3H). 13C-NMR (100 MHz, DMSO-d6): δ 171.8, 169.4, 98.6, 79.8, 67.8, 65.7, 41.9, 32.5, 29.7, 27.7, 19.4.

3.3.6. Oxidation of (5,5-Dimethyl-1,3-dioxan-2-yl)methanol (1e):

1e (146 mg, 1.0 equiv, 1.0 mmol) was oxidized according to the general procedure outlined above, scaled-up by ten (2 mol % TEMPO, 2 mol % TBAB, 3.3 equiv. mCPBA, 1 h reaction time), including the work-up sequence. Prior to extraction, the aqueous phase was saturated with solid NaCl. The crude mixture of products was purified using column chromatography (silica gel, 1:9 to 3:7 EtOAc/hexane) to give the minor products 5e–1 (4 mg, impure with other by-products) and 5e–2 (3.5 mg), and the major product 4e (19 mg, 0.14 mmol, 14%) as colorless oils [48]. Due to their minute amounts, only 1H-NMR characterization is available for the minor products.
4e: TLC: Rf = 0.3 (3:7 EtOAc/hexane eluent). 1H-NMR (400 MHz, CDCl3): δ 8.10 (s, 1H), 4.01 (s, 2H), 3.34 (s, 2H), 2.11 (br s, 1H), 0.93 (s, 6H). 13C-NMR (100 MHz, CDCl3): δ 161.6, 69.0, 68.2, 36.3, 21.5.
5e–1: 1H-NMR (400 MHz, CDCl3): δ 5.40 (s, 1H), 4.66 (t, J = 4.7 Hz, 1H), 3.76 (d, J = 11.0 Hz, 2H), 3.71 (d, J = 4.7 Hz, 2H), 3.63 (d, J = 11.2 Hz, 2H), 3.44 (d, J = 10.6 Hz, 2H), 3.37 (d, J = 11.1 Hz, 2H), 1.19 (s, 3H), 0.98 (s, 3H), 0.97 (s, 3H), 0.73 (s, 3H).
5e–2: 1H-NMR (400 MHz, CDCl3): δ 8.10 (s, 1H), 5.26 (s, 1H), 4.03 (s, 2H), 3.73 (d, J = 11.0 Hz, 2H), 3.39 (s, 2H), 3.38 (d, J = 10.5 Hz, 2H), 0.99 (s, 9H), 0.95 (s, 3H).

3.3.7. Oxidation of ((3aR,9aS)-3a,4,9,9a-Tetrahydronaphtho[2,3-d][1,3]dioxol-2-yl)methanol (1f):

1f (21 mg, 1.0 equiv, 0.1 mmol) was oxidized according to the general procedure outlined above (2 mol % TEMPO, 2 mol % TBAB, 3.3 equiv. mCPBA, 1 h reaction time), excluding the work-up sequence. The product 4f was characterized from the crude reaction mixture without purification.
1H-NMR (400 MHz, DMSO-d6): δ 8.28 (s, 1H), 7.09 (m, 4H), 5.17 (t, J = 4.2 Hz,1H), 4.07 (ddd, J = 7.5, 5.3, 1.8 Hz,1H), 2.94 (m, 4H). 13C-NMR (100 MHz, DMSO-d6): δ 162.3, 133.9, 133.2, 128.7, 128.6, 125.9, 125.8, 75.2, 72.4, 34.3, 31.9.

3.3.8. Oxidation of (4,4,5,5-Tetramethyl-1,3-dioxolan-2-yl)methanol (1g):

1g (32 mg, 1.0 equiv, 0.2 mmol) was oxidized according to the general procedure outlined above (2 mol % TEMPO, 2 mol % TBAB, 3.3 equiv. mCPBA, 1 h reaction time), excluding the work-up sequence. The crude mixture was analyzed by NMR and was found to contain a 1:2.4 mixture of 4g [49] and 5g [50,51].
4g: 1H-NMR (400 MHz, DMSO-d6): δ 8.34 (s, 1H), 1.37 (s, 6H), 1.09 (s, 6H). 13C-NMR (100 MHz, DMSO-d6): δ 162.6, 85.9, 72.9, 25.0, 22.1.
5g: 1H-NMR (400 MHz, DMSO-d6): δ 1.31 (s, 12H). 13C-NMR (100 MHz, DMSO-d6): δ 153.3, 86.1, 22.0.

3.3.9. Oxidation of Methyl 3,5-di-O-(2,4-dichlorobenzyl)- α-D-Ribofuranoside (1h):

Commercially available 1h (152 mg, 0.3 mmol, 1 equiv) was oxidized according to the general procedure outlined above, scaled-up by three (5 mol % TEMPO, 5 mol % TBAB, 2.2 equiv. mCPBA, 4 h reaction time), including the work-up sequence. The product was characterized from the crude reaction mixture without purification.
1H-NMR (400 MHz, CDCl3): δ 7.37 (m, 2H), 7.30 (d, J = 8.2 Hz, 1H), 7.27 (d, J = 8.2 Hz, 1H), 7.21 (d, J = 8.3 Hz, 1H), 7.21 (d, J = 8.3 Hz, 1H), 5.59 (d, J = 8.3 Hz, 1H), 5.00 (s, 1H), 4.99 (d, J = 12.2 Hz, 1H), 4.75 (d, J = 12.3 Hz, 1H), 4.63 (d, J = 13.0 Hz, 1H), 4.51 (d, J = 13.0 Hz, 1H), 4.09 (dt, J = 8.3, 3.0 Hz, 1H), 3.82 (d, J = 3.0 Hz, 2H), 3.53 (s, 3H). 13C-NMR (100 MHz, CDCl3): δ 163.4, 135.2, 134.5, 134.3, 133.9, 133.6, 132.3, 131.1, 129.8, 129.6, 129.3, 127.4, 127.3, 100.0, 95.3, 70.3, 68.3, 68.2, 68.0, 56.9.

4. Conclusions

In conclusion, we examined a number of additional classes of β-oxy-substituted primary alcohols in the domino two-step oxidation reaction that we disclosed recently. Furthermore, in a number of cases, formation of useful end-products was observed. Finally, the experiments helped to establish the order of migratory aptitudes of α-oxy-substituted alkyls in the BV reaction and compared them to that of hydrogen (α-hydroxyalkyl > α-alkoxyalkyl > α,α-dialkoxyalkyl > α-aryloxyalkyl > hydrogen > α-alkoxyalkoxyalkyl > α-acyloxyalkyl).

Supplementary Materials

The following are available online at https://www.mdpi.com/2073-4344/10/11/1275/s1, 1H- and 13C-NMR spectra of the synthesized substrates and identified products, as well as indicative MS spectra of some of the compounds.

Author Contributions

Conceptualization and methodology, T.T. and M.P.; investigation and data curation, T.T.; writing—original draft preparation, T.T. and M.P.; writing—review and editing, M.P.; supervision, project administration and funding acquisition, M.P. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Acknowledgments

The authors are grateful to Tel Aviv University for financial support.

Conflicts of Interest

The authors declare no conflict of interest.

References and Notes

  1. Tojo, G.; Fernandez, M. Oxidation of Alcohols to Aldehydes and Ketones; Springer: New York, NY, USA, 2006. [Google Scholar]
  2. Krow, G.R. The Baeyer-Villiger oxidation of ketones and aldehydes. Org. React. 1993, 43, 251–798. [Google Scholar]
  3. ten Brink, G.J.; Arends, I.W.C.E.; Sheldon, R.A. The Baeyer-Villiger reaction: New developments toward greener procedures. Chem. Rev. 2004, 104, 4105–4123. [Google Scholar] [CrossRef]
  4. Strukul, G. Transition metal catalysis in the Baeyer-Villiger oxidation of ketones. Angew. Chem. Int. Ed. 1998, 37, 1199–1209. [Google Scholar] [CrossRef]
  5. Yaremenko, I.A.; Vil, V.A.; Demchuk, D.V.; Terent’ev, A.O. Rearrangements of organic peroxides and related processes. Beilstein. J. Org. Chem. 2016, 12, 1647–1748. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  6. For examples of oxidation of secondary alcohols to esters in two separate steps, see subsequent references 7-15, while for infrequent examples of one-pot oxidation of secondary alcohols to esters, see references 16-19.
  7. Tsang, R.; Fraser-Reid, B. Pyranose alpha-enones provide ready access to functionalized trans-decalins via bis-annulated pyranosides obtained by intramolecular Diels-Alder reactions—a key intermediate for Forskolin. J. Org. Chem. 1992, 57, 1065–1067. [Google Scholar] [CrossRef]
  8. Chida, N.; Tobe, T.; Ogawa, S. Regioselective Baeyer-Villiger reaction of polyhydroxycyclohexanone derivatives. Tetrahedron Lett. 1994, 35, 7249–7252. [Google Scholar] [CrossRef]
  9. Mecerreyes, D.; Atthoff, B.; Boduch, K.A.; Trollsas, M.; Hedrick, J.L. Unimolecular combination of an atom transfer radical polymerization initiator and a lactone monomer as a route to new graft copolymers. Macromolecules 1999, 32, 5175–5182. [Google Scholar] [CrossRef]
  10. Ishmuratov, G.Y.; Yakovleva, M.P.; Ganieva, V.A.; Gareeva, G.R.; Muslukhov, R.R.; Tolstikov, G.A. Synthesis of optically pure 3R-methylcyclopentan-1-one from L-(-)-menthol. Chem. Nat. Compd. 2005, 41, 549–551. [Google Scholar] [CrossRef]
  11. Rainbolt, E.A.; Washington, K.E.; Biewer, M.C.; Stefan, M.C. Towards smart polymeric drug carriers: Self-assembling γ-substituted polycaprolactones with highly tunable thermoresponsive behavior. J. Mater. Chem. B 2013, 1, 6532–6537. [Google Scholar] [CrossRef]
  12. Surnar, B.; Jayakannan, M. Stimuli-responsive poly(caprolactone) vesicles for dual drug delivery under the gastrointestinal tract. Biomacromolecules 2013, 14, 4377–4387. [Google Scholar] [CrossRef]
  13. Ercole, F.; Rodda, A.E.; Meagher, L.; Forsythe, J.S.; Dove, A.P. Surface grafted poly(ε-caprolactone) prepared using organocatalysed ring-opening polymerisation followed by SI-ATRP. Polym. Chem. 2014, 5, 2809–2815. [Google Scholar] [CrossRef]
  14. Yamauchi, S.; Nishimura, H.; Nishiwaki, H. Stereoselective syntheses of cryptocarya diacetate and all its stereoisomers in optically pure forms. Biosci. Biotechnol. Biochem. 2015, 79, 16–24. [Google Scholar] [CrossRef]
  15. Malhotra, M.; Surnar, B.; Jayakannan, M. Polymer topology driven enzymatic biodegradation in polycaprolactone block and random copolymer architectures for drug delivery to cancer cells. Macromolecules 2016, 49, 8098–8112. [Google Scholar] [CrossRef]
  16. Cella, J.A.; McGrath, J.P.; Kelley, J.A.; El Soukkary, O.; Hilpert, L. Applications of the peracid-mediated oxidation of alcohols. J. Org. Chem. 1977, 42, 2077–2080. [Google Scholar] [CrossRef]
  17. Chrobok, A. An efficient tandem oxidation of cyclohexanol to ε-caprolactone with peroxyacids and TEMPO catalyst in ionic liquids as solvents. Synlett 2011, 391–395. [Google Scholar] [CrossRef]
  18. Weisser, F.; Stevens, H.; Klein, J.; van der Meer, M.; Hohloch, S.; Sarkar, B. Tailoring Ru(II) pyridine/triazole oxygenation catalysts and using photoreactivity to probe their electronic properties. Chem. Eur. J. 2015, 21, 8926–8938. [Google Scholar] [CrossRef]
  19. Dijkmans, J.; Schutyser, W.; Dusselier, M.; Sels, B.F. Snβ-zeolite catalyzed oxido-reduction cascade chemistry with biomass-derived molecules. Chem. Commun. 2016, 52, 6712–6715. [Google Scholar] [CrossRef]
  20. Figadere, B.; Franck, X. Carboxylic Acids: Synthesis from alcohols. In Science of Synthesis; Panek, J.S., Ed.; Georg Thieme Verlag: Stuttgart, Germany, 2006; Volume 20a, pp. 173–204. [Google Scholar]
  21. For reactions of electron-rich benzaldehydes (Dakin reaction), see subsequent references 22–23, while for reactions of aldehydes with a nitrogen- or an oxygen-substituted α-carbon, see references 24–31.
  22. Hocking, M.B.; Bhandari, K.; Shell, B.; Smyth, T.A. Steric and pH effects on the rate of Dakin oxidation of acylphenols. J. Org. Chem. 1982, 47, 4208–4215. [Google Scholar] [CrossRef]
  23. Saikia, B.; Borah, P. A new avenue to the Dakin reaction in H2O2–WERSA. RSC Adv. 2015, 5, 105583–105586. [Google Scholar] [CrossRef]
  24. Alcaide, B.; Aly, M.F.; Sierra, M.A. Stereoselective synthesis of 3-substituted 4-(formyloxy)-2-azetidinones by the unusual Baeyer-Villiger reaction of beta-lactam aldehydes. Scope and synthetic applications. J. Org. Chem. 1996, 61, 8819–8825. [Google Scholar] [CrossRef]
  25. Deboer, A.; Ellwanger, R.E. Baeyer-Villiger oxidation of Δ1(9)-Octalone-2 and Δ1(8)-Indanone-2. J. Org. Chem. 1974, 39, 77–83. [Google Scholar] [CrossRef]
  26. Labadie, G.R.; Luna, L.E.; Gonzalez-Sierra, M.; Cravero, R.M. Synthesis of the tetracyclic bis(acetal) lactone portion of Saudin. Eur. J. Org. Chem. 2003, 3429–3434. [Google Scholar] [CrossRef]
  27. Jeso, V.; Iqbal, S.; Hernandez, P.; Cameron, M.D.; Park, H.; LoGrasso, P.V.; Micalizio, G.C. Synthesis of benzoquinone Ansamycin-inspired macrocyclic lactams from Shikimic acid. Angew. Chem. Int. Ed. 2013, 52, 4800–4804. [Google Scholar] [CrossRef]
  28. Nicolaou, K.C.; Frederick, M.O.; Burtoloso, A.C.B.; Denton, R.M.; Rivas, F.; Cole, K.P.; Aversa, R.J.; Gibe, R.; Umezawa, T.; Suzuki, T. Chemical synthesis of the GHIJKLMNO ring system of maitotoxin. J. Am. Chem. Soc. 2008, 130, 7466–7476. [Google Scholar] [CrossRef]
  29. Chaubet, G.; Bourgeois, D.; Périgaud, C. Synthetic studies towards new nucleoside analogues: Preparation of (±)-1′,4′-dimethyladenosine. Eur. J. Org. Chem. 2011, 319–326. [Google Scholar] [CrossRef]
  30. Himmelbauer, M.; Farcet, J.B.; Gagnepain, J.; Mulzer, J. Palladium-catalyzed carbo-oxygenation: The Bielschowskysin case. Org. Lett. 2013, 15, 3098–3101. [Google Scholar] [CrossRef]
  31. Urabe, F.; Nagashima, S.; Takahashi, K.; Ishihara, J.; Hatakeyama, S. Total synthesis of (-)-Cinatrin C1 based on an In(OTf)3-catalyzed Conia-ene reaction. J. Org. Chem. 2013, 78, 3847–3857. [Google Scholar] [CrossRef]
  32. Targel, T.; Ramesh, P.; Portnoy, M. Domino two-step oxidation of β-alkoxy alcohols to hemiacetal esters: Linking a stoichiometric step to an organocatalytic step with a common organic oxidant. Eur. J. Org. Chem. 2018, 23, 3017–3021. [Google Scholar] [CrossRef]
  33. For cases when such transformation was conducted in two successive, but separate, steps, see refs. 7,8.
  34. For similar comparison of some of these migratory aptitudes in ketones, see ref. 8.
  35. The endocyclic character of the alkoxyalkyl should not be a factor in this comparison, since the related 3-hydroxytetrahydrofurane undergoes a rapid cascade reaction with the insertion of oxygen near this group.
  36. Jimenez, F.; del Carmen Cruz, M.; Zuniga, C.; Martinez, M.A.; Chamorro, G.; Diza, F.; Tamariz, J. Aryloxyacetic esters structurally related to α-Asarone as potential antifungal agents. Med. Chem. Res. 2010, 19, 33–57. [Google Scholar] [CrossRef]
  37. 1b was prepared from a triol precursor by trans-acetalization with benzaldehyde dimethylacetal, see Materials and Methods.
  38. 38. See, for instance: Xie, Y.; Zhang, J.; Tian, G.; Xu, M.; Hu, T.; Jiang, X.; Shen, J. A neighboring group participation strategy: Facile synthesis of 3,5-di-O-benzoyl-2-C-methyl-d-arabino-γ-lactone. Tetrahedron Lett. 2015, 56, 4345–4348. [Google Scholar] [CrossRef]
  39. In order to drive the reaction to completion, excess of mCPBA was applied.
  40. Lehtinen, C.; Nevalainen, V.; Brunow, G. Experimental and computational studies on solvent effects in reactions of peracid-aldehyde adducts. Tetrahedron 2001, 57, 4741–4751. [Google Scholar] [CrossRef]
  41. Ogata, Y.; Sawaki, Y. Kinetics of the Baeyer-Villiger reaction of benzaldehydes with perbenzoic acid in aquoorganic solvents. J. Org. Chem. 1969, 34, 3985–3991. [Google Scholar] [CrossRef]
  42. Flogel, O.; Okala Amombo, M.G.; Reissig, H.U.; Zahn, G.; Brudgam, I.; Hartl, H. A stereoselective and short total synthesis of the polyhydroxylated γ-amino acid (-)-detoxinine, based on stereoselective preparation of dihydropyrrole derivatives from lithiated alkoxyallenes. Chem. Eur. J. 2003, 9, 1405–1415. [Google Scholar] [CrossRef]
  43. Miyazawa, S.; Shinoda, M.; Kawahara, T.; Watanabe, N.; Harada, H.; Iida, D.; Terauchi, H.; Nagakawa, J.; Fujisaki, H.; Kubota, A.; et al. Preparation of Benzimidazole Derivatives as Gastric Acid Secretion Inhibitors. U.S. Patent Appl. Publ. US 2007/0010542 A1, 11 January 2007. [Google Scholar]
  44. Huo, C.; Yang, H.; Cui, Q.C.; Dou, Q.P.; Chan, T.H. Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs. Bioorg. Med. Chem. 2010, 18, 1252–1258. [Google Scholar] [CrossRef] [Green Version]
  45. Lei, P.-s.; Ogawa, Y.; Kovac, P. New N-acylating reagent derived from 3-deoxy-L-glycero-tetronic acid. J. Carbohydr. Chem. 1996, 15, 485–500. [Google Scholar] [CrossRef]
  46. Esmurziev, A.M.; Reimers, A.; Andreassen, T.; Simic, N.; Sundby, E.; Hoff, B.H. Benzoylated uronic acid building blocks and synthesis of N-uronate conjugates of Lamotrigine. Molecules 2012, 17, 820–835. [Google Scholar] [CrossRef] [Green Version]
  47. 47. For characterization of 3d, see: Edwards, J.T.; Merchant, R.R.; McClymont, K.S.; Knouse, K.W.; Qin, T.; Malins, L.R.; Vokits, B.; Shaw, S.A.; Bao, D.H.; Wei, F.-L.; et al. Decarboxylative alkenylation. Nature 2017, 545, 213–219. [Google Scholar]
  48. For characterization of 4e, see: Filliatre, C.; Brigand, G.; Lalande, R. Peroxidation of oxygenated heterocyclic compounds. Bull. Soc. Chim. Fr. 1971, 170–176. [Google Scholar]
  49. Goosen, A.; McCleland, C.W. Reaction of 1,3-dioxolans with iodine monochloride: The scope and mechanism of formation of 1,3-dioxolan-2-ylium dichloroiodates(I). J. Chem. Soc. Perkin Trans. I 1981, 977–983. [Google Scholar] [CrossRef]
  50. Suzuki, M.; Sugai, T. Mechanistic studies on nitrosation–deaminocyclization of mono-carbamoylated vicinal amino alcohols and diols: A new preparative in situ formation of ethanediazo hydroxide for the ethylation of carboxylates under mild conditions. Bull. Chem. Soc. Jpn. 2004, 77, 1217–1227. [Google Scholar] [CrossRef]
  51. Pihlaja, K.; Rossi, K. Conformational analysis. Part XLIII. 13C Chemical shifts and coupling constants as proof of the nonplanarity of the 2-oxo-1,3-dioxalane ring. Acta Chem. Scand. B, 1977; 31, 899–902. [Google Scholar]
Catalysts 10 01275 sch001 550
Scheme 1. Previously published reactions of β-O-substituted primary alcohols under one-pot oxidation conditions: (a) β-alkoxy alcohols; (b) β-acyloxy alcohols; (c) γ-alkoxy-β-hydroxyalcohols [32].
Scheme 1. Previously published reactions of β-O-substituted primary alcohols under one-pot oxidation conditions: (a) β-alkoxy alcohols; (b) β-acyloxy alcohols; (c) γ-alkoxy-β-hydroxyalcohols [32].
Catalysts 10 01275 sch001
Catalysts 10 01275 sch002 550
Scheme 2. The migrating group preference in the Criegee intermediate [2,3,4,5] defines the outcome of the reaction: hemiacetal formates (red arrows) vs. carboxylic acids (blue arrows).
Scheme 2. The migrating group preference in the Criegee intermediate [2,3,4,5] defines the outcome of the reaction: hemiacetal formates (red arrows) vs. carboxylic acids (blue arrows).
Catalysts 10 01275 sch002
Catalysts 10 01275 sch003 550
Scheme 3. Preference for the migration of the hydroxy alkyl over alkoxyalkyl in the domino reaction [32].
Scheme 3. Preference for the migration of the hydroxy alkyl over alkoxyalkyl in the domino reaction [32].
Catalysts 10 01275 sch003
Catalysts 10 01275 sch004 550
Scheme 4. Secondary transformation of the hemiacetal formate product 2d.
Scheme 4. Secondary transformation of the hemiacetal formate product 2d.
Catalysts 10 01275 sch004
Catalysts 10 01275 sch005 550
Scheme 5. Synthesis of compounds 1e-g. Reagents and conditions: (i) NMO (N-methylmorpholine N-oxide), OsO4 cat., tBuOH/acetone/H2O, rt; (ii) A, TsOHcat., toluene, reflux; (iii) H2, Pd/Ccat., MeOH, rt.
Scheme 5. Synthesis of compounds 1e-g. Reagents and conditions: (i) NMO (N-methylmorpholine N-oxide), OsO4 cat., tBuOH/acetone/H2O, rt; (ii) A, TsOHcat., toluene, reflux; (iii) H2, Pd/Ccat., MeOH, rt.
Catalysts 10 01275 sch005
Catalysts 10 01275 sch006 550
Scheme 6. Domino oxidation of substrates (1e–g) and secondary reactions of the formed dialkoxymethyl carboxylates.
Scheme 6. Domino oxidation of substrates (1e–g) and secondary reactions of the formed dialkoxymethyl carboxylates.
Catalysts 10 01275 sch006
Table
Table 1. Reactions of additional substrates under domino oxidation conditions.1
Table 1. Reactions of additional substrates under domino oxidation conditions.1
EntrySubstrateTime (h)Consumption (%)Products (Product Ratio)
1 Catalysts 10 01275 i0013100 Catalysts 10 01275 i002(1: 0.4)
2 Catalysts 10 01275 i0031782 Catalysts 10 01275 i004
3 Catalysts 10 01275 i0053100 Catalysts 10 01275 i006
4 Catalysts 10 01275 i007387 Catalysts 10 01275 i008(1: 6.7)
5 Catalysts 10 01275 i0091100 Catalysts 10 01275 i010
6 Catalysts 10 01275 i0111100 Catalysts 10 01275 i012
7 Catalysts 10 01275 i0131100 Catalysts 10 01275 i014
8 Catalysts 10 01275 i0154100 Catalysts 10 01275 i016
1 Reaction conditions: 1 equiv of substrate with 2.2 to 6.6 equiv of mCPBA, 2 to 5 molar % TEMPO, 2 to 5 molar % tetra-n-butylammonium bromide (TBAB), dichloromethane (DCM) (8 mL/mmol substrate), rt. For exact amounts for each entry, see the Materials and Methods Section.
Table
Table 2. Influence of the solvent on the distribution of the reaction products 1.
Table 2. Influence of the solvent on the distribution of the reaction products 1.
EntrySubstrateSolventConsumption (%)Product Ratio 2
11ibenzene10014:1
21iDCM10011:1
3 31iEtOAc4710:1
41iACN963.1:1
51dbenzene861:4.9
61dDCM871:6.7
7 31dEtOAc791:24
81dACN100Acid only
1 Reaction conditions: 1 equiv of substrate with 2.2 equiv of mCPBA, 2 or 5 molar % TEMPO, 2 or 5 molar % TBAB, solvent (8 mL/mmol substrate), 1–3 h, rt. For exact amounts and time for each entry, see Materials and Methods Section. 2 Ratio between the hemiacetal ester(s) and the carboxylic acid products. 3 Without TBAB.
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Targel, T.; Portnoy, M. Baeyer-Villiger-Including Domino Two-Step Oxidations of β-O-Substituted Primary Alcohols: Reflection of the Migratory Aptitudes of O-Substituted Alkyl Group in the Outcome of the Reaction. Catalysts 2020, 10, 1275. https://doi.org/10.3390/catal10111275

AMA Style

Targel T, Portnoy M. Baeyer-Villiger-Including Domino Two-Step Oxidations of β-O-Substituted Primary Alcohols: Reflection of the Migratory Aptitudes of O-Substituted Alkyl Group in the Outcome of the Reaction. Catalysts. 2020; 10(11):1275. https://doi.org/10.3390/catal10111275

Chicago/Turabian Style

Targel, Tom, and Moshe Portnoy. 2020. "Baeyer-Villiger-Including Domino Two-Step Oxidations of β-O-Substituted Primary Alcohols: Reflection of the Migratory Aptitudes of O-Substituted Alkyl Group in the Outcome of the Reaction" Catalysts 10, no. 11: 1275. https://doi.org/10.3390/catal10111275

APA Style

Targel, T., & Portnoy, M. (2020). Baeyer-Villiger-Including Domino Two-Step Oxidations of β-O-Substituted Primary Alcohols: Reflection of the Migratory Aptitudes of O-Substituted Alkyl Group in the Outcome of the Reaction. Catalysts, 10(11), 1275. https://doi.org/10.3390/catal10111275

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