Fatty Acid Hydratases: Versatile Catalysts to Access Hydroxy Fatty Acids in Efficient Syntheses of Industrial Interest
Abstract
:1. Introduction
2. Application of Fatty Acid Hydratase in Synthesis and Process Development
3. Cascade Processes Involving Fatty Acid Hydratase
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Strain (Source of Fatty Acid Hydratase) | Product | Conv./% | Product-Amount/g L−1 | PRODUCTIVITY/g L−1 h−1 | Substrate Loading |
---|---|---|---|---|---|
Candida tropicalis DSM 3152 (wild-type) [38] | 3-hydroxy-Δ9-cis-1,18- octadecenedioic acid | - | 19.4 | 0.8 | 70 mL d−1 |
Stenotrophomonas nitritireducens (wild-type) [46] | 10-hydroxystearic acid | - | 31.5 | 7.9 | 15 g/L |
Stenotrophomonas maltophilia (exp. in E. coli) [37] | 10-hydroxystearic acid | 98 | 49.0 | 12.3 | 50 g/L |
Lysinibacillus fusiformis (exp. in E. coli) [48] | 10-hydroxystearic acid | 94 | 40.0 | 384 | 40 g/L |
Stenotrophomonas maltophilia (exp. in E. coli) [49] | 10-hydroxystearic acid | 91 | 46.0 | 197 | 50 g/L |
Lysinibacillus fusiformis (exp. in E. coli) [50] | 10,12-dihydroxystearic acid | 90 | 13.5 | 108 | 15 g/L |
Stenotrophomonas nitritireducens (exp. in E. coli) [55] | 10-hydroxy-12(Z)- octadecenoic acid 10-hydroxysteric acid | 89; 88 | 5.0, 0.85 | 102, 22 | 7.5 g/L |
Lactobacillus acidophilus (exp. in E. coli) [56] | 13-hydroxy-9(Z)-octadecenoic acid | 79 | 79.0 | 631 | 100 g/L |
Lactobacillus plantarum (exp. in E. coli) [58] | (S)-10-hydoxy-cis-12-octadecenoic acid | 98 | 280.0 | 552 | 90 g/L |
Stenotrophomonas maltophilia, Lactobacillus acidophilus (exp. in E. coli) [60] | 10-monohydroxy fatty acids 7,8-dihydroxy fatty acids | 65, 81 | 21.7, 13.3 | - | 50 mL (reaction volume) |
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Löwe, J.; Gröger, H. Fatty Acid Hydratases: Versatile Catalysts to Access Hydroxy Fatty Acids in Efficient Syntheses of Industrial Interest. Catalysts 2020, 10, 287. https://doi.org/10.3390/catal10030287
Löwe J, Gröger H. Fatty Acid Hydratases: Versatile Catalysts to Access Hydroxy Fatty Acids in Efficient Syntheses of Industrial Interest. Catalysts. 2020; 10(3):287. https://doi.org/10.3390/catal10030287
Chicago/Turabian StyleLöwe, Jana, and Harald Gröger. 2020. "Fatty Acid Hydratases: Versatile Catalysts to Access Hydroxy Fatty Acids in Efficient Syntheses of Industrial Interest" Catalysts 10, no. 3: 287. https://doi.org/10.3390/catal10030287