Copper-Catalyzed/Hypervalent Iodine-Mediated Functionalization of Unactivated Compounds

Papis, Marta; Foschi, Francesca; Colombo, Sara; Beccalli, Egle Maria; Loro, Camilla; Broggini, Gianluigi

doi:10.3390/catal13091243

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Copper-Catalyzed/Hypervalent Iodine-Mediated Functionalization of Unactivated Compounds

by

Marta Papis

¹,

Francesca Foschi

¹,

Sara Colombo

¹,

Egle Maria Beccalli

²,

Camilla Loro

^1,* and

Gianluigi Broggini

^1,*

¹

Dipartimento di Scienza e Alta Tecnologia, Università degli Studi dell’Insubria, Via Valleggio 9, 22100 Como, Italy

²

DISFARM Sezione di Chimica Generale e Organica “A. Marchesini”, Università degli Studi di Milano, Via Venezian 21, 20133 Milano, Italy

^*

Authors to whom correspondence should be addressed.

Catalysts 2023, 13(9), 1243; https://doi.org/10.3390/catal13091243

Submission received: 28 July 2023 / Revised: 14 August 2023 / Accepted: 24 August 2023 / Published: 26 August 2023

(This article belongs to the Special Issue Advancements in Catalytic Oxidations in Organic Synthesis)

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Abstract

The functionalization of unactivated substrates through the combination of copper catalysts and hypervalent iodine reagents represents a versatile tool in organic synthesis to access various classes of compounds. The hypervalent iodine derivatives can be used simply as oxidizing agents to regenerate the catalytic species or they can associate the functionalization of the starting material. In this review, special attention will be paid to methodologies which provide the introduction of nucleophiles into the reagent by use of suitable benziodoxol(on)es or iodonium salts. Many reactions concern C- and N-arylations, but may also involve formation of different carbon–carbon and carbon–nitrogen bonds, carbon–oxygen as well as carbon–halogen and carbon–phosphorus bonds.

Keywords: copper catalysis; hypervalent iodine; difunctionalization reactions; arylation; homogeneous catalysis

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MDPI and ACS Style

Papis, M.; Foschi, F.; Colombo, S.; Beccalli, E.M.; Loro, C.; Broggini, G. Copper-Catalyzed/Hypervalent Iodine-Mediated Functionalization of Unactivated Compounds. Catalysts 2023, 13, 1243. https://doi.org/10.3390/catal13091243

AMA Style

Papis M, Foschi F, Colombo S, Beccalli EM, Loro C, Broggini G. Copper-Catalyzed/Hypervalent Iodine-Mediated Functionalization of Unactivated Compounds. Catalysts. 2023; 13(9):1243. https://doi.org/10.3390/catal13091243

Chicago/Turabian Style

Papis, Marta, Francesca Foschi, Sara Colombo, Egle Maria Beccalli, Camilla Loro, and Gianluigi Broggini. 2023. "Copper-Catalyzed/Hypervalent Iodine-Mediated Functionalization of Unactivated Compounds" Catalysts 13, no. 9: 1243. https://doi.org/10.3390/catal13091243

APA Style

Papis, M., Foschi, F., Colombo, S., Beccalli, E. M., Loro, C., & Broggini, G. (2023). Copper-Catalyzed/Hypervalent Iodine-Mediated Functionalization of Unactivated Compounds. Catalysts, 13(9), 1243. https://doi.org/10.3390/catal13091243

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Copper-Catalyzed/Hypervalent Iodine-Mediated Functionalization of Unactivated Compounds

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