The Suzuki–Miyaura Cross-Coupling as a Versatile Tool for Peptide Diversification and Cyclization
Abstract
:1. Introduction
2. Derivatization of Amino Acids and Peptides in Solution
2.1. Access to and Derivatization of (Pseudo)halogenated Aromatic Amino acid Substrates
2.2. Synthesis of Borylated Aromatic and Aliphatic Amino Acids and Subsequent Derivatization
2.3. Coupling of Amino Acids: Synthesis of Biaryl-Bridged Dipeptides
2.4. Suzuki–Miyaura Reaction on Peptidic Substrates
3. Solid-Phase Derivatizations of Peptide Substrates
4. Formation of Biaryl-Bridges in Peptidic Natural Products and Peptide Macrocyclics
5. Protein Derivatization
6. The Suzuki–Miyaura Reaction as a Tool towards Improved Biological Activity
7. Conclusions
Acknowledgments
Conflicts of Interest
References
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Willemse, T.; Schepens, W.; Vlijmen, H.W.T.v.; Maes, B.U.W.; Ballet, S. The Suzuki–Miyaura Cross-Coupling as a Versatile Tool for Peptide Diversification and Cyclization. Catalysts 2017, 7, 74. https://doi.org/10.3390/catal7030074
Willemse T, Schepens W, Vlijmen HWTv, Maes BUW, Ballet S. The Suzuki–Miyaura Cross-Coupling as a Versatile Tool for Peptide Diversification and Cyclization. Catalysts. 2017; 7(3):74. https://doi.org/10.3390/catal7030074
Chicago/Turabian StyleWillemse, Tom, Wim Schepens, Herman W. T. van Vlijmen, Bert U. W. Maes, and Steven Ballet. 2017. "The Suzuki–Miyaura Cross-Coupling as a Versatile Tool for Peptide Diversification and Cyclization" Catalysts 7, no. 3: 74. https://doi.org/10.3390/catal7030074