Pd-Catalyzed Mizoroki-Heck Reactions Using Fluorine-Containing Agents as the Cross-Coupling Partners

Yang, Jing; Zhao, Hua-Wen; He, Jian; Zhang, Cheng-Pan

doi:10.3390/catal8010023

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Pd-Catalyzed Mizoroki-Heck Reactions Using Fluorine-Containing Agents as the Cross-Coupling Partners

by

Jing Yang

¹,

Hua-Wen Zhao

^1,*,

Jian He

¹ and

Cheng-Pan Zhang

^1,2,*

¹

Department of Chemistry, College of Pharmacy, Army Medical University, Shapingba, Chongqing 400038, China

²

School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road,Wuhan 430070, China

^*

Authors to whom correspondence should be addressed.

Catalysts 2018, 8(1), 23; https://doi.org/10.3390/catal8010023

Submission received: 27 December 2017 / Revised: 10 January 2018 / Accepted: 10 January 2018 / Published: 14 January 2018

(This article belongs to the Special Issue Catalyzed Mizoroki–Heck Reaction or C–H activation)

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Abstract

The Mizoroki-Heck reaction represents one of the most convenient methods for carbon-carbon double bond formation in the synthesis of small organic molecules, natural products, pharmaceuticals, agrochemicals, and functional materials. Fluorine-containing organic compounds have found wide applications in the research areas of materials and life sciences over the past several decades. The incorporation of fluorine-containing segments into the target molecules by the Mizoroki-Heck reactions is highly attractive, as these reactions efficiently construct carbon-carbon double bonds bearing fluorinated functional groups by simple procedures. This review summarizes the palladium-catalyzed Mizoroki-Heck reactions using various fluorine-containing reagents as the cross-coupling partners. The first part of the review describes the Pd-catalyzed Mizoroki-Heck reactions of aryl halides or pseudo-halides with the fluorinated alkenes, and the second part discusses the Pd-catalyzed Mizoroki-Heck reactions of the fluorinated halides or pseudo-halides with alkenes. Variants of the Pd-catalyzed Mizoroki-Heck reactions with fluorine-containing reagents are also briefly depicted. This work supplies an overview, as well as a guide, to both younger and more established researchers in order to attract more attention and contributions in the realm of Mizoroki-Heck reactions with fluorine-containing participants.

Keywords: Mizoroki-Heck reaction; Pd-catalyzed; fluorine; cross-coupling; alkenes; halides

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MDPI and ACS Style

Yang, J.; Zhao, H.-W.; He, J.; Zhang, C.-P. Pd-Catalyzed Mizoroki-Heck Reactions Using Fluorine-Containing Agents as the Cross-Coupling Partners. Catalysts 2018, 8, 23. https://doi.org/10.3390/catal8010023

AMA Style

Yang J, Zhao H-W, He J, Zhang C-P. Pd-Catalyzed Mizoroki-Heck Reactions Using Fluorine-Containing Agents as the Cross-Coupling Partners. Catalysts. 2018; 8(1):23. https://doi.org/10.3390/catal8010023

Chicago/Turabian Style

Yang, Jing, Hua-Wen Zhao, Jian He, and Cheng-Pan Zhang. 2018. "Pd-Catalyzed Mizoroki-Heck Reactions Using Fluorine-Containing Agents as the Cross-Coupling Partners" Catalysts 8, no. 1: 23. https://doi.org/10.3390/catal8010023

APA Style

Yang, J., Zhao, H.-W., He, J., & Zhang, C.-P. (2018). Pd-Catalyzed Mizoroki-Heck Reactions Using Fluorine-Containing Agents as the Cross-Coupling Partners. Catalysts, 8(1), 23. https://doi.org/10.3390/catal8010023

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Pd-Catalyzed Mizoroki-Heck Reactions Using Fluorine-Containing Agents as the Cross-Coupling Partners

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