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Article

Novel Magnetically-Recyclable, Nitrogen-Doped Fe3O4@Pd NPs for Suzuki–Miyaura Coupling and Their Application in the Synthesis of Crizotinib

by
Kai Zheng
1,
Chao Shen
1,2,*,
Jun Qiao
2,*,
Jianying Tong
2,
Jianzhong Jin
2 and
Pengfei Zhang
3
1
School of Chemistry and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, China
2
College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China
3
College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China
*
Authors to whom correspondence should be addressed.
Catalysts 2018, 8(10), 443; https://doi.org/10.3390/catal8100443
Submission received: 5 September 2018 / Revised: 13 September 2018 / Accepted: 22 September 2018 / Published: 10 October 2018
(This article belongs to the Special Issue Catalysts for Suzuki–Miyaura Coupling Reaction)
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Abstract

Novel magnetically recyclable Fe3O4@Pd nanoparticles (NPs) were favorably synthesized by fixing palladium on the surface of nitrogen-doped magnetic nanocomposites. These catalysts were fully characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetric analysis (TG), and X-ray photoelectron spectroscopy (XPS). The prepared catalyst exhibited good catalytic activity for Suzuki–Miyaura coupling reactions of aryl or heteroaryl halides (I, Br, Cl) with arylboronic acids. These as-prepared catalysts could be readily isolated from the reaction liquid by an external magnet and reused at least ten times with excellent yields achieved. In addition, using this protocol, the marketed drug crizotinib (anti-tumor) could be easily synthesized.
Keywords: heterogeneous catalyst; magnetically; palladium catalysts; nitrogen-doped; Suzuki coupling; crizotinib heterogeneous catalyst; magnetically; palladium catalysts; nitrogen-doped; Suzuki coupling; crizotinib
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MDPI and ACS Style

Zheng, K.; Shen, C.; Qiao, J.; Tong, J.; Jin, J.; Zhang, P. Novel Magnetically-Recyclable, Nitrogen-Doped Fe3O4@Pd NPs for Suzuki–Miyaura Coupling and Their Application in the Synthesis of Crizotinib. Catalysts 2018, 8, 443. https://doi.org/10.3390/catal8100443

AMA Style

Zheng K, Shen C, Qiao J, Tong J, Jin J, Zhang P. Novel Magnetically-Recyclable, Nitrogen-Doped Fe3O4@Pd NPs for Suzuki–Miyaura Coupling and Their Application in the Synthesis of Crizotinib. Catalysts. 2018; 8(10):443. https://doi.org/10.3390/catal8100443

Chicago/Turabian Style

Zheng, Kai, Chao Shen, Jun Qiao, Jianying Tong, Jianzhong Jin, and Pengfei Zhang. 2018. "Novel Magnetically-Recyclable, Nitrogen-Doped Fe3O4@Pd NPs for Suzuki–Miyaura Coupling and Their Application in the Synthesis of Crizotinib" Catalysts 8, no. 10: 443. https://doi.org/10.3390/catal8100443

APA Style

Zheng, K., Shen, C., Qiao, J., Tong, J., Jin, J., & Zhang, P. (2018). Novel Magnetically-Recyclable, Nitrogen-Doped Fe3O4@Pd NPs for Suzuki–Miyaura Coupling and Their Application in the Synthesis of Crizotinib. Catalysts, 8(10), 443. https://doi.org/10.3390/catal8100443

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