PLMA-b-POEGMA Amphiphilic Block Copolymers as Nanocarriers for the Encapsulation of Magnetic Nanoparticles and Indomethacin
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. PLMA-b-POEGMA Block Copolymers Synthesis
2.3. Synthesis of Iron Oxide Nanoparticles
2.4. Preparation of PLMA-b-POEGMA Micelles Loaded with Magnetic Nanoparticles
2.5. Preparation of PLMA-b-POEGMA Micelles Loaded with Magnetic Nanoparticles and Indomethacin
2.6. Methods
3. Results and Discussion
3.1. Encapsulation of Fe2O3 Nanoparticles in the PLMA-b-POEGMA Micelles
3.2. Encapsulation of Both Iron Oxide Nps and IND into PLMA-b-POEGMA Micelles
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Block copolymers | NPs loaded | NPs and IND loaded | |||||||
---|---|---|---|---|---|---|---|---|---|
Sample | Mw a (×104) (g/mol) | Mw/Mn a | wt % PLMA b | Dh c (nm) | PDI c | Dh c (nm) | PDI c | Dh c (nm) | PDI c |
PLMA22-b-POEGMA58 | 3.3 | 1.30 | 16 | 162 | 0.28 | - | - | 166 | 0.33 |
PLMA22-b-POEGMA32 | 2.07 | 1.31 | 27 | 122 | 0.35 | 198 | 0.37 | 194 | 0.39 |
PLMA22-b-POEGMA13 | 1.17 | 1.18 | 52 | 140 | 0.31 | 200 | 0.35 | - | - |
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Skandalis, A.; Sergides, A.; Bakandritsos, A.; Pispas, S. PLMA-b-POEGMA Amphiphilic Block Copolymers as Nanocarriers for the Encapsulation of Magnetic Nanoparticles and Indomethacin. Polymers 2018, 10, 14. https://doi.org/10.3390/polym10010014
Skandalis A, Sergides A, Bakandritsos A, Pispas S. PLMA-b-POEGMA Amphiphilic Block Copolymers as Nanocarriers for the Encapsulation of Magnetic Nanoparticles and Indomethacin. Polymers. 2018; 10(1):14. https://doi.org/10.3390/polym10010014
Chicago/Turabian StyleSkandalis, Athanasios, Andreas Sergides, Aristides Bakandritsos, and Stergios Pispas. 2018. "PLMA-b-POEGMA Amphiphilic Block Copolymers as Nanocarriers for the Encapsulation of Magnetic Nanoparticles and Indomethacin" Polymers 10, no. 1: 14. https://doi.org/10.3390/polym10010014