Hyaluronic Acid-Decorated Laponite® Nanocomposites for Targeted Anticancer Drug Delivery
Abstract
:![](https://pub.mdpi-res.com/polymers/polymers-11-00137/article_deploy/html/images/polymers-11-00137-ag-550.jpg?1724334283)
Graphical Abstract
1. Introduction
2. Experiment
2.1. Preparation and Characterization of DOX-Loaded Nanocomposites
2.2. Cell Culture
2.3. In Vitro Cytotoxicity Assay and Cell Morphology Observation
2.4. Cellular Uptake
3. Results and Discussion
3.1. Synthesis and Characterization of LM-HA/DOX
3.2. DOX Encapsulation and Release
3.3. Targeted Therapeutic Efficacy of LM-HA/DOX
3.4. CD44-Mediated Cellular Uptake
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Materials | ζ-Potential (mV) | Hydrodynamic Size (nm) |
---|---|---|
LAP | −39.6 ± 0.7 | 86.5 ± 5.1 |
LM-NH2 | −12.0 ± 2.0 | 184.0 ± 1.9 |
LM-HA | −14.1 ± 1.4 | 282.6 ± 12.7 |
LM-HA/DOX | −10.8 ± 0.7 | 412.7 ± 16.1 |
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Jiang, T.; Chen, G.; Shi, X.; Guo, R. Hyaluronic Acid-Decorated Laponite® Nanocomposites for Targeted Anticancer Drug Delivery. Polymers 2019, 11, 137. https://doi.org/10.3390/polym11010137
Jiang T, Chen G, Shi X, Guo R. Hyaluronic Acid-Decorated Laponite® Nanocomposites for Targeted Anticancer Drug Delivery. Polymers. 2019; 11(1):137. https://doi.org/10.3390/polym11010137
Chicago/Turabian StyleJiang, Tingting, Guangxiang Chen, Xiangyang Shi, and Rui Guo. 2019. "Hyaluronic Acid-Decorated Laponite® Nanocomposites for Targeted Anticancer Drug Delivery" Polymers 11, no. 1: 137. https://doi.org/10.3390/polym11010137