History of Cyclodextrin Nanosponges
Abstract
:1. Introduction
2. Origin and Historical Development of Nanosponges Over the Last 50 Years
2.1. From the 1960s to the 1980s: Origin of Insoluble Crosslinked Cyclodextrin Polymers
2.2. From the 1980s to the 1990s: Investigation on Polymer Properties and Applications
2.3. 1999:“In the Beginning Was the Word”
2.4. From 2000 to 2009: New Millennium Came with New Applications
2.5. From 2010 to 2015: Focus on Nanosponges as Delivery Systems
2.6. From 2016 to Present: State-of-the-Art and Future Prospects of Nanosponges
3. Conclusions and Future Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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Year | Nanosponge/Cross-Linker | Drug | Indication | References |
---|---|---|---|---|
2010–2015 | β-CD/DPC | Camptothecin | Pharmaceutical application | [46,70] |
β-CD/CDI | Resveratrol | Pharmaceutical application | [58] | |
Fluorescent NS | Paclitaxel | Pharmaceutical application | [45] | |
Carboxylated nanosponges | Acyclovir | Antivirial efficacy | [51] | |
β-CD/CDI | Rutin, phloridzin and chlorogenic acid | Anti-cancer, anti-diabetic, antiobesity, neuronal protective properties etc. | [57] | |
β-CD/DPC | Gabapentin | Treatment of partial seizures in pediatric | [71] | |
2016 | β-CD/PMDA | Lansoprazole | Gastric ulcers | [72] |
β-CD/DPC | Quercetin | Cancer treatment | [73] | |
β-CD /CDI | Erlotinib hydrochloride (ERL) | Cancer treatment | [74] | |
GSH–NS (β-CD/PMDA) | Doxorubicin | Anticancer activity | [75] | |
2017 | β-CD/EDTA | Ibuprofen | diseases | [76] |
β-CD/DPC | 2-(3,4-dimethoxyphenyl)-3-phenyl-4H-pyrido [1,2-a] pyrimidin-4-one (DB103) | Cardiovascular diseases, drug-eluting stents (DES) | [77] | |
β-CD/DPC | Chrysin | Optimal anti-oxidant and anti-tumorous properties | [78] | |
β-CD/DPC | Nifedipine | Treatment of angina pectoris and hypertension | [79] | |
β-CD/CDI | Camptothecin (CPT) | Antitumor efficacy, inhibition effect on prostate cancer | [80,81] | |
β-CD/DPC | Cefadroxil (CFD) | Against variety of Gram-positive and Gram-negative bacteria | [82] | |
β-CD/DPC | Efavirenz and Rilpivirine HCl | HIV | [83,84] | |
β-CD/PMDA | Erlotinib glutathione | Cancer | [85] | |
2018 | β-CD/DMC | Ellagic acid | Cancer | [86] |
β-CD/DPC | Mebendazole | Lymphatic worm infestations | [16] | |
β-CD/TDI | Naproxen | Inflammation | [87] | |
Electrospun | N,N-diethyl-3-toluamide | Infectious diseases | [88] | |
β-CD/PMDA | ||||
β-CD/CDI; PMDA | Rilpivrine | HIV | [89] | |
β-CD/CDI | Atorvastatin calcium | Dyslipidemia | [90] | |
β-CD/DPC | Norfloxacin | Urinary tract infections | [91] | |
β-CD/CDI | Doxorubicin | Cancer | [92] | |
2019 | β-CD/NDCA | Sage essential oil | Diabetes | [93] |
β-CD/DPC; PMDA | Curcumin and Resveratrol | Cancer | [15,94,95] | |
β-CD / DPC | Ferulic acid and Imatinib Mesylate | Cancer | [17,96] | |
β-CD/EPI | Curcumin | Cancer | [97,98] | |
β-CD/CDI | Kynurenic acid and Paliperidone | Neurological disorders and Schizophrenia | [99,100] | |
β-CD/PMDA | Imiquimod | Topical diseases | [101] |
Years | Nanosponge/Crosslinker | Adsorbate | Field | References |
---|---|---|---|---|
1980–2000 | CDs/HMDI, phenyl isocyanate, EPI | Naringin, limonin, debittering of grapefruit juice, | Food | [23] |
CDs/EPI | Caffeine, vanillin and theobromine | [24] | ||
CDs / EPI, HMDI and Phenyl isocyanate | Textile dyes | Textile | [25] | |
Aromatic pollutants, such as phenol, p-nitrophenol, benzoic acid, p-nitrobenzoic acid, β-naphthol, chlorophenols and 4-tert-butylbenzoic acid | Environment | [26] | ||
CDs/HMDI or toluene 2,6-diisocyanate | Organic pollutants | Water Treatment (Environment) | [119] | |
2000–2009 | β-CD/EPI | Naphthalene, 2-naphthol and naproxen | Water Treatment (Environment) | [29] |
CDs/CDI, DMC | Chlorinated persistent organic pollutants (POPs) | Water Treatment (Environment) | [32] | |
CD/HMDI or toluene-2,4-diisocyanate | p-nitrophenol and pentachlorophenol, | [30] | ||
β-CD/PMDA | Heavy metals (Al (III), Mn (II), Co (II), Ni (II), Cu (II), Cd (II) etc.) | Water Treatment (Environment) | [35] | |
Carcinogenic N-nitrosodimethylamine (NDMA) | Water Treatment (Environment) | [34] | ||
Carbonate NSs | Increase the thermostability, pH stability and storage stability of catechol 1,2-dioxygenase | As a substrate for enzyme immobilization | [39] | |
2010–2019 | β-CD/DPC | Phosphorus derivatives | Flame retardancy | [64] |
α, β, γ-CD / CDI; PMDA | Oxygen | Hypoxia/Reoxygenation and Biomedical application | [41,120] | |
β-CD /CDI | Oxygen, carbon dioxide and 1-methylcyclopropene 1-MCP carriers. | biomedical, environmental and floriculture application | [40] | |
β-CD/PMDA | Iron fertilizer | Agricultural application | [62] | |
CD/DPC | Xanthene derivatives | Catalytic Activity | [121] | |
CD/CDI | Coriander essential oil | food packaging | [122] |
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Krabicová, I.; Appleton, S.L.; Tannous, M.; Hoti, G.; Caldera, F.; Rubin Pedrazzo, A.; Cecone, C.; Cavalli, R.; Trotta, F. History of Cyclodextrin Nanosponges. Polymers 2020, 12, 1122. https://doi.org/10.3390/polym12051122
Krabicová I, Appleton SL, Tannous M, Hoti G, Caldera F, Rubin Pedrazzo A, Cecone C, Cavalli R, Trotta F. History of Cyclodextrin Nanosponges. Polymers. 2020; 12(5):1122. https://doi.org/10.3390/polym12051122
Chicago/Turabian StyleKrabicová, Ilona, Silvia Lucia Appleton, Maria Tannous, Gjylije Hoti, Fabrizio Caldera, Alberto Rubin Pedrazzo, Claudio Cecone, Roberta Cavalli, and Francesco Trotta. 2020. "History of Cyclodextrin Nanosponges" Polymers 12, no. 5: 1122. https://doi.org/10.3390/polym12051122