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Volume 12
Issue 6
10.3390/polym12061237
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Review

Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting

by
Jie Xu
1,
Shuangshuang Zheng
2,
Xueyan Hu
1,
Liying Li
1,
Wenfang Li
1,
Roxanne Parungao
3,
Yiwei Wang
3,
Yi Nie
2,4,*,
Tianqing Liu
1,* and
Kedong Song
1,*
1
State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China
2
Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou 450000, China
3
Burns Research Group, ANZAC Research Institute, University of Sydney, Concord, NSW 2139, Australia
4
Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
*
Authors to whom correspondence should be addressed.
Polymers 2020, 12(6), 1237; https://doi.org/10.3390/polym12061237
Submission received: 4 February 2020 / Revised: 23 February 2020 / Accepted: 25 February 2020 / Published: 29 May 2020
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Abstract

The skin plays an important role in protecting the human body, and wound healing must be set in motion immediately following injury or trauma to restore the normal structure and function of skin. The extracellular matrix component of the skin mainly consists of collagen, glycosaminoglycan (GAG), elastin and hyaluronic acid (HA). Recently, natural collagen, polysaccharide and their derivatives such as collagen, gelatin, alginate, chitosan and pectin have been selected as the matrix materials of bioink to construct a functional artificial skin due to their biocompatible and biodegradable properties by 3D bioprinting, which is a revolutionary technology with the potential to transform both research and medical therapeutics. In this review, we outline the current skin bioprinting technologies and the bioink components for skin bioprinting. We also summarize the bioink products practiced in research recently and current challenges to guide future research to develop in a promising direction. While there are challenges regarding currently available skin bioprinting, addressing these issues will facilitate the rapid advancement of 3D skin bioprinting and its ability to mimic the native anatomy and physiology of skin and surrounding tissues in the future.
Keywords: bioink; skin tissue engineering; 3D bioprinting; wound healing; skin regeneration bioink; skin tissue engineering; 3D bioprinting; wound healing; skin regeneration
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MDPI and ACS Style

Xu, J.; Zheng, S.; Hu, X.; Li, L.; Li, W.; Parungao, R.; Wang, Y.; Nie, Y.; Liu, T.; Song, K. Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting. Polymers 2020, 12, 1237. https://doi.org/10.3390/polym12061237

AMA Style

Xu J, Zheng S, Hu X, Li L, Li W, Parungao R, Wang Y, Nie Y, Liu T, Song K. Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting. Polymers. 2020; 12(6):1237. https://doi.org/10.3390/polym12061237

Chicago/Turabian Style

Xu, Jie, Shuangshuang Zheng, Xueyan Hu, Liying Li, Wenfang Li, Roxanne Parungao, Yiwei Wang, Yi Nie, Tianqing Liu, and Kedong Song. 2020. "Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting" Polymers 12, no. 6: 1237. https://doi.org/10.3390/polym12061237

APA Style

Xu, J., Zheng, S., Hu, X., Li, L., Li, W., Parungao, R., Wang, Y., Nie, Y., Liu, T., & Song, K. (2020). Advances in the Research of Bioinks Based on Natural Collagen, Polysaccharide and Their Derivatives for Skin 3D Bioprinting. Polymers, 12(6), 1237. https://doi.org/10.3390/polym12061237

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