Controlled Release of Chlorogenic Acid from Polyvinyl Alcohol/Poly(γ-Glutamic Acid) Blended Electrospun Nanofiber Mats with Potential Applications in Diabetic Foot Treatment
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Biosynthesis of Poly (γ-glutamic acid)
2.3. Preparation of PVA and PVA/γ-PGA Nanofibers by Electrospinning
2.4. Chlorogenic Acid Release
2.5. Characterization Techniques
3. Results
3.1. γ-PGA Characterization
3.2. Presence of γ-PGA in the PVA Nanofibers
3.3. Morphology
3.4. In Vitro Release of CGA from the PVA and PVA/γ-PGA Fibers
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Sample | K1 (h−1) | R2 Pseudo-First-Order |
---|---|---|
PVA/γ-PGA 10 | 0.29 | 0.96 |
PVA/γ-PGA 5 | 0.33 | 0.99 |
PVA | 0.11 | 0.98 |
Sample | Peppas Model | Weibull Model | ||||
η | K | R2 | α | β | R2 | |
PVA/γ-PGA 10 | 0.21 ± 0.04 | 0.28 ± 0.05 | 0.84 | 0.22 ± 0.05 | 0.42 ± 0.05 | 0.92 |
PVA/γ-PGA 5 | 0.19 ± 0.04 | 0.24 ± 0.05 | 0.78 | 0.23 ± 0.06 | 0.30 ± 0.06 | 0.83 |
PVA | 0.21 ± 0.02 | 0.13 ± 0.01 | 0.92 | - | - | - |
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Sandoval-Herrera, I.; Romero-García, J.; Ledezma-Pérez, A.; Alvarado-Canché, C.; Torres-Lubian, R.; De-León, A. Controlled Release of Chlorogenic Acid from Polyvinyl Alcohol/Poly(γ-Glutamic Acid) Blended Electrospun Nanofiber Mats with Potential Applications in Diabetic Foot Treatment. Polymers 2021, 13, 2943. https://doi.org/10.3390/polym13172943
Sandoval-Herrera I, Romero-García J, Ledezma-Pérez A, Alvarado-Canché C, Torres-Lubian R, De-León A. Controlled Release of Chlorogenic Acid from Polyvinyl Alcohol/Poly(γ-Glutamic Acid) Blended Electrospun Nanofiber Mats with Potential Applications in Diabetic Foot Treatment. Polymers. 2021; 13(17):2943. https://doi.org/10.3390/polym13172943
Chicago/Turabian StyleSandoval-Herrera, Isela, Jorge Romero-García, Antonio Ledezma-Pérez, Carmen Alvarado-Canché, Román Torres-Lubian, and Arxel De-León. 2021. "Controlled Release of Chlorogenic Acid from Polyvinyl Alcohol/Poly(γ-Glutamic Acid) Blended Electrospun Nanofiber Mats with Potential Applications in Diabetic Foot Treatment" Polymers 13, no. 17: 2943. https://doi.org/10.3390/polym13172943