Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine
Abstract
:1. Introduction
2. Experimental
2.1. Reagents and Apparatus
2.2. Preparation of Solutions
2.3. Electrode Modification
2.4. Experimental Measurements of PRX
3. Results and Discussion
3.1. Optimization of the Sensor’s Fabrication Conditions
3.1.1. Effect of Deposition Time of AuNPs
3.1.2. Monomer (dl-met) Concentrations
3.1.3. Electropolymerization of dl-met
3.2. Effect of pH
3.3. Effect of DPV Operational Parameters
3.4. Surface Topography of the Sensor
3.5. Electrochemical Characterization of the Modified Sensor
3.6. Effect of Possible Interferents on the Response (Selectivity)
3.7. Validation of the Poly (dl-Met)/AuNPs-GCE Sensor Response
3.8. Applications of the Designed Sensor for the Detection of Paroxetine in Pharmaceutical Formulations
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sensor Material | Analytical Method | Linear Range (M) | LOD (M) | R2 | Reference |
---|---|---|---|---|---|
poly (dl-met)/AuNPs-GCE | DPV | 5 × 10−11–5 × 10−9 | 1.00 × 10−11 | 0.991 | Present work |
5 × 10−9–1 × 10−4 | 0.995 | ||||
rGO/PWA/PGE | DPV | 9 × 10−8–1 × 10−6 | 9.00 × 10−10 | 0.998 | [13] |
Au/PANSA/CYP2D6 | DPV | 0.5 × 10−8–0.5 × 10−7 | 2.00 × 10−9 | 0.990 | [2] |
BDDE | SWAdSV | 7.0 × 10−7–3.5 × 10−6 | 6.95 × 10−9 | 0.999 | [14] |
EPGE | SWAdSV | 1.0 × 10−8–5.0 × 10−6 | 1.03 × 10−9 | 0.999 | [14] |
Nafion-MWCNTs/GCE | DPV | 0.1 × 10−6–2.5 × 10−6 | 0.62 × 10−7 | 0.998 | [1] |
Sample | Taken (µg mL−1) | Found (ng mL−1) | Recovery% ± SD | RSD% |
---|---|---|---|---|
Paroxetine CR® 37.5 | 0.27 | 0.28 | 103.04% ± 0.05 | 0.46 |
mg/tab | 0.99 | 0.97 | 97.57% ± 0.37 | 3.11 |
2.87 | 2.91 | 98.62% ± 0.04 | 2.98 | |
Paroxetine CR® 25 | 0.27 | 0.26 | 96.29% ± 0.07 | 1.24 |
mg/tab | 0.99 | 1.04 | 105.05% ± 0.02 | 0.21 |
2.87 | 2.917 | 101.16% ± 0.40 | 2.98 | |
Paroxetine CR® 12.5 | 0.27 | 0.27 | 103.40% ± 0.58 | 5.41 |
mg/tab | 0.99 | 0.98 | 99.10% ± 0.21 | 1.80 |
2.87 | 2.94 | 102.50% ± 0.41 | 3.05 |
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Al-Mhyawi, S.R.; Ahmed, R.K.; El Nashar, R.M. Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine. Polymers 2021, 13, 3981. https://doi.org/10.3390/polym13223981
Al-Mhyawi SR, Ahmed RK, El Nashar RM. Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine. Polymers. 2021; 13(22):3981. https://doi.org/10.3390/polym13223981
Chicago/Turabian StyleAl-Mhyawi, Saedah R., Riham K. Ahmed, and Rasha M. El Nashar. 2021. "Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine" Polymers 13, no. 22: 3981. https://doi.org/10.3390/polym13223981