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Volume 14
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10.3390/polym14132593
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Article

Bevacizumab-Controlled Delivery from Polymeric Microparticle Systems as Interesting Tools for Pathologic Angiogenesis Diseases

by
Giulia De Negri Atanasio
1,
Pier Francesco Ferrari
1,*,
Roberta Campardelli
1,*,
Giuseppe Firpo
2,
Patrizia Perego
1,3 and
Domenico Palombo
3,4,5
1
Department of Civil, Chemical and Environmental Engineering, University of Genoa, via Opera Pia, 15, 16145 Genoa, Italy
2
Department of Physics, University of Genoa, via Dodecaneso, 33, 16146 Genoa, Italy
3
Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity, University of Genoa, via Montallegro, 1, 16145 Genoa, Italy
4
Department of Surgical and Integrated Diagnostic Sciences, University of Genoa, viale Benedetto XV, 6, 16132 Genoa, Italy
5
Vascular and Endovascular Surgery Unit, IRCCS Ospedale Policlinico San Martino, largo Rosanna Benzi, 10, 16132 Genoa, Italy
*
Authors to whom correspondence should be addressed.
Polymers 2022, 14(13), 2593; https://doi.org/10.3390/polym14132593
Submission received: 24 May 2022 / Revised: 17 June 2022 / Accepted: 19 June 2022 / Published: 26 June 2022
(This article belongs to the Special Issue Innovative Polymeric Devices for Cardiovascular Disease Detection and Treatments)
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Abstract

This work is a comparative study among three different biocompatible and biodegradable polymers, poly(lactic-co-glycolic acid), poly(ε-caprolactone), and poly(lactic acid), used to produce microparticles for the encapsulation of bevacizumab for drug delivery purposes. All the formulations were produced using the double emulsion water-oil-water evaporation method and characterized in terms of particle mean diameter, particle size distribution, and bevacizumab entrapment efficiency. Bevacizumab cumulative release was taken into consideration to study the dissolution kinetics from the three different polymeric delivery platforms for a period of 50 days at 37 °C in phosphate buffered saline and mathematical models of the drug release kinetic were attempted in order to describe the release phenomena from the different types of the studied microparticles. Finally, cell viability on human endothelial cell line EA.hy926 was studied to define the maximum cytocompatible concentration for each microsystem, registering the mitochondrial functionality through MTS assay.
Keywords: oncology; cardiovascular diseases; biodegradable polymers; monoclonal antibodies; drug release kinetics oncology; cardiovascular diseases; biodegradable polymers; monoclonal antibodies; drug release kinetics

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MDPI and ACS Style

De Negri Atanasio, G.; Ferrari, P.F.; Campardelli, R.; Firpo, G.; Perego, P.; Palombo, D. Bevacizumab-Controlled Delivery from Polymeric Microparticle Systems as Interesting Tools for Pathologic Angiogenesis Diseases. Polymers 2022, 14, 2593. https://doi.org/10.3390/polym14132593

AMA Style

De Negri Atanasio G, Ferrari PF, Campardelli R, Firpo G, Perego P, Palombo D. Bevacizumab-Controlled Delivery from Polymeric Microparticle Systems as Interesting Tools for Pathologic Angiogenesis Diseases. Polymers. 2022; 14(13):2593. https://doi.org/10.3390/polym14132593

Chicago/Turabian Style

De Negri Atanasio, Giulia, Pier Francesco Ferrari, Roberta Campardelli, Giuseppe Firpo, Patrizia Perego, and Domenico Palombo. 2022. "Bevacizumab-Controlled Delivery from Polymeric Microparticle Systems as Interesting Tools for Pathologic Angiogenesis Diseases" Polymers 14, no. 13: 2593. https://doi.org/10.3390/polym14132593

APA Style

De Negri Atanasio, G., Ferrari, P. F., Campardelli, R., Firpo, G., Perego, P., & Palombo, D. (2022). Bevacizumab-Controlled Delivery from Polymeric Microparticle Systems as Interesting Tools for Pathologic Angiogenesis Diseases. Polymers, 14(13), 2593. https://doi.org/10.3390/polym14132593

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