Polyglycerols as Multi-Functional Platforms: Synthesis and Biomedical Applicationsâ€
Round 1
Reviewer 1 Report
In the manuscript entitled “Polyglycerols as multifunctional platforms: synthesis and biomedical applications” by Pouyan at al. the various synthetic routes of polyglycerol and overview of polyglycerol applications in biomedical field are described. The review is very well prepared, interesting and contains abundant collection of literature data on syntheses and biomedical applications of broad range of molecular weight and architecture of polyglycerols.
Thus, I recommend the manuscript for publication after minor revision as indicated.
- According IUPAC nomenclature (Stepto RFT, at al. Pure Appl. Chem. 2009, 81, 351-353) “dispersity” instead of “polydispersity” is recommended to determine the molecular weight distribution of polymers.
- Please, consider a few additional schemes of chemical reactions described in the manuscript.
Author Response
Thank you very much for your kind input. Please find our point to point respond in the following:
Reviewer 1
In the manuscript entitled “Polyglycerols as multifunctional platforms: synthesis and biomedical applications” by Pouyan at al. the various synthetic routes of polyglycerol and overview of polyglycerol applications in biomedical field are described. The review is very well prepared, interesting and contains abundant collection of literature data on syntheses and biomedical applications of broad range of molecular weight and architecture of polyglycerols.
- Thus, I recommend the manuscript for publication after minor revision as indicated.
2. According IUPAC nomenclature (Stepto RFT, at al. Pure Appl. Chem. 2009, 81, 351-353) “dispersity” instead of “polydispersity” is recommended to determine the molecular weight distribution of polymers.
Thank you for your feedback. The term of polydispersity is changed to dispersity throughout the manuscript.
3. Please, consider a few additional schemes of chemical reactions described in the manuscript.
As the scheme of the mentioned reactions is reported extensively in the literature, we decided to mention the most relevant ones in addition to more illustrative figures. We believe that adding more schemes might be out of scope for a for a minireview.
Reviewer 2 Report
The article, entitled "Polymeric Carriers for Delivery Systems in Biomedical Applications – in Memory of Professor Andrzej Dworak '' is a well structured, comprehensive review of the field of polyglycerols with different structures. The authors well discussed in detail the different possible synthetic routes of the production of both the linear and hyperbranched polyglycerols. The leading contribution of Professor Andrzej Dworak in this field is highlighted properly and well supported. The intensive research on the application of polyglycerols in the biomedical fields is well presented by the appropriate and adequate references but some recent works which deal with polyglycerol based bioconjugates should be mentioned.
So, based on thorough reading, this article is recommended for publication in MDPI Polymers.
Author Response
Thank you for positive feedback. Kindly find the response in the next section:
Reviewer 2
The article, entitled "Polymeric Carriers for Delivery Systems in Biomedical Applications – in Memory of Professor Andrzej Dworak '' is a well structured, comprehensive review of the field of polyglycerols with different structures. The authors well discussed in detail the different possible synthetic routes of the production of both the linear and hyperbranched polyglycerols. The leading contribution of Professor Andrzej Dworak in this field is highlighted properly and well supported. The intensive research on the application of polyglycerols in the biomedical fields is well presented by the appropriate and adequate references but some recent works which deal with polyglycerol based bioconjugates should be mentioned.
The authors added the adequate recent work concerning polyglycerol based bioconjugates.
