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Volume 16
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10.3390/polym16131798
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Modification of a Carboxymethyl Cellulose/Poly(vinyl alcohol) Hydrogel Film with Citric Acid and Glutaraldehyde Crosslink Agents to Enhance the Anti-Inflammatory Effectiveness of Triamcinolone Acetonide in Wound Healing

by
Kanticha Pratinthong
1,
Winita Punyodom
2,3,*,
Pensak Jantrawut
4,5,
Kittisak Jantanasakulwong
1,3,5,
Wirongrong Tongdeesoontorn
6,7,
Montira Sriyai
8,9,
Rangsan Panyathip
1,8,
Sarinthip Thanakkasaranee
1,3,5,
Patnarin Worajittiphon
2,3,
Nuttapol Tanadchangsaeng
10 and
Pornchai Rachtanapun
1,3,5,*
1
Division of Packaging Technology, School of Agro-Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand
2
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
3
Center of Excellence in Materials Science and Technology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
4
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Muang, Chiang Mai 50200, Thailand
5
Center of Excellence in Agro Bio-Circular-Green Industry (Agro BCG), Chiang Mai University, Chiang Mai 50100, Thailand
6
School of Agro-Industry, Mae Fah Luang University, 333 Moo 1 Tasud, Chiang Rai 57100, Thailand
7
Research Center of Innovative Food Packaging and Biomaterials Unit, Mae Fah Luang University, 333 Moo 1 Tasud, Chiang Rai 57100, Thailand
8
Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand
9
Bioplastics Production Laboratory for Medical Applications, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
10
College of Biomedical Engineering, Rangsit University, Pathumthani 12000, Thailand
*
Authors to whom correspondence should be addressed.
Polymers 2024, 16(13), 1798; https://doi.org/10.3390/polym16131798
Submission received: 14 May 2024 / Revised: 21 June 2024 / Accepted: 21 June 2024 / Published: 25 June 2024
(This article belongs to the Special Issue Biodegradable Polymers and Their Emerging Applications)
Versions Notes

Abstract

Anti-inflammatory wound healing involves targeted drug delivery to the wound site using hydrogel materials to prolong drug effectiveness. In this work, hydrogel films were fabricated using carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) crosslinked with citric acid (CA) and glutaraldehyde (GA) at different concentrations. The crosslinker densities were optimized with various CA (2–10% w/v) and GA (1–5% v/v) concentrations. The optimized crosslink densities in the hydrogel exhibited additional functional group peaks in the FT-IR spectra at 1740 cm⁻1 for the C=O stretching of the ester linkage in CA and at 1060 cm⁻1 for the C-O-C stretching of the ether group in GA. Significantly, the internal porous structures of hydrogel composite films improved density, swelling capacities, solubility percentage reduction, and decreased water retention capacities with optimized crosslinker densities. Therefore, these hydrogel composite films were utilized as drug carriers for controlled drug release within 24 h during medical treatment. Moreover, the hydrogel films demonstrated increased triamcinolone acetonide (TAA) absorption with higher crosslinker density, resulting in delayed drug release and improved TAA efficiency in anti-inflammatory activity. As a result, the modified hydrogel showed the capability of being an alternative material with enhanced anti-inflammatory efficiency with hydrogel films.
Keywords: hydrogel; carboxymethyl cellulose; poly (vinyl alcohol); crosslinking; triamcinolone acetonide hydrogel; carboxymethyl cellulose; poly (vinyl alcohol); crosslinking; triamcinolone acetonide

Share and Cite

MDPI and ACS Style

Pratinthong, K.; Punyodom, W.; Jantrawut, P.; Jantanasakulwong, K.; Tongdeesoontorn, W.; Sriyai, M.; Panyathip, R.; Thanakkasaranee, S.; Worajittiphon, P.; Tanadchangsaeng, N.; et al. Modification of a Carboxymethyl Cellulose/Poly(vinyl alcohol) Hydrogel Film with Citric Acid and Glutaraldehyde Crosslink Agents to Enhance the Anti-Inflammatory Effectiveness of Triamcinolone Acetonide in Wound Healing. Polymers 2024, 16, 1798. https://doi.org/10.3390/polym16131798

AMA Style

Pratinthong K, Punyodom W, Jantrawut P, Jantanasakulwong K, Tongdeesoontorn W, Sriyai M, Panyathip R, Thanakkasaranee S, Worajittiphon P, Tanadchangsaeng N, et al. Modification of a Carboxymethyl Cellulose/Poly(vinyl alcohol) Hydrogel Film with Citric Acid and Glutaraldehyde Crosslink Agents to Enhance the Anti-Inflammatory Effectiveness of Triamcinolone Acetonide in Wound Healing. Polymers. 2024; 16(13):1798. https://doi.org/10.3390/polym16131798

Chicago/Turabian Style

Pratinthong, Kanticha, Winita Punyodom, Pensak Jantrawut, Kittisak Jantanasakulwong, Wirongrong Tongdeesoontorn, Montira Sriyai, Rangsan Panyathip, Sarinthip Thanakkasaranee, Patnarin Worajittiphon, Nuttapol Tanadchangsaeng, and et al. 2024. "Modification of a Carboxymethyl Cellulose/Poly(vinyl alcohol) Hydrogel Film with Citric Acid and Glutaraldehyde Crosslink Agents to Enhance the Anti-Inflammatory Effectiveness of Triamcinolone Acetonide in Wound Healing" Polymers 16, no. 13: 1798. https://doi.org/10.3390/polym16131798

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