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Volume 16
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10.3390/polym16202876
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Article

Fabrication and Properties of Hydrogel Dressings Based on Genipin Crosslinked Chondroitin Sulfate and Chitosan

by
Ling Wang
1,
Xiaoyue Ding
1,
Xiaorui He
1,
Ning Tian
1,
Peng Ding
1,
Wei Guo
1,
Oseweuba Valentine Okoro
2,
Yanfang Sun
3,
Guohua Jiang
4,5,
Zhenzhong Liu
6,*,
Armin Shavandi
2 and
Lei Nie
1,*
1
College of Life Sciences, Xinyang Normal University, Xinyang 464000, China
2
3BIO-BioMatter, École Polytechnique de Bruxelles, Université libre de Bruxelles (ULB), Avenue F.D. Roosevelt, 50-CP 165/61, 1050 Brussels, Belgium
3
College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China
4
School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China
5
International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China
6
Taizhou Key Laboratory of Medical Devices and Advanced Materials, Taizhou Institute of Zhejiang University, Taizhou 318000, China
*
Authors to whom correspondence should be addressed.
Polymers 2024, 16(20), 2876; https://doi.org/10.3390/polym16202876
Submission received: 9 August 2024 / Revised: 3 October 2024 / Accepted: 8 October 2024 / Published: 11 October 2024
(This article belongs to the Special Issue Bioactive and Biomedical Hydrogel Dressings for Wound Healing)
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Abstract

Multifunctional hydrogel dressings remain highly sought after for the promotion of skin wound regeneration. In the present study, multifunctional CHS-DA/HACC (CH) hydrogels with an interpenetrated network were constructed using hydroxypropyl trimethyl ammonium chloride modified chitosan (HACC) and dopamine-modified chondroitin sulfate (CHS-DA), using genipin as crosslinker. The synthesis of HACC and CHS-DA was effectively confirmed using Fourier transform infrared (FT-IR) analysis and 1H nuclear magnetic resonance (1H NMR) spectroscopy. The prepared CH hydrogels exhibited a network of interconnected pores within the microstructure. Furthermore, rheological testing demonstrated that CH hydrogels exhibited strong mechanical properties, stability, and injectability. Further characterization investigations showed that the CH hydrogels showed favorable self-healing and self-adhesion properties. It was also shown that increasing HACC concentration ratio was positively correlated with the antibacterial activity of CH hydrogels, as evidenced by their resistance to Escherichia coli and Staphylococcus aureus. Additionally, Cell Counting Kit-8 (CCK-8) tests, fluorescent images, and a cell scratch assay demonstrated that CH hydrogels had good biocompatibility and cell migration ability. The multifunctional interpenetrated network hydrogels were shown to have good antibacterial properties, antioxidant properties, stable storage modulus and loss modulus, injectable properties, self-healing properties, and biocompatibility, highlighting their potential as wound dressings in wound healing applications.
Keywords: genipin; chitosan; chondroitin sulfate; interpenetrated network; hydrogel; wound dressings genipin; chitosan; chondroitin sulfate; interpenetrated network; hydrogel; wound dressings

Share and Cite

MDPI and ACS Style

Wang, L.; Ding, X.; He, X.; Tian, N.; Ding, P.; Guo, W.; Okoro, O.V.; Sun, Y.; Jiang, G.; Liu, Z.; et al. Fabrication and Properties of Hydrogel Dressings Based on Genipin Crosslinked Chondroitin Sulfate and Chitosan. Polymers 2024, 16, 2876. https://doi.org/10.3390/polym16202876

AMA Style

Wang L, Ding X, He X, Tian N, Ding P, Guo W, Okoro OV, Sun Y, Jiang G, Liu Z, et al. Fabrication and Properties of Hydrogel Dressings Based on Genipin Crosslinked Chondroitin Sulfate and Chitosan. Polymers. 2024; 16(20):2876. https://doi.org/10.3390/polym16202876

Chicago/Turabian Style

Wang, Ling, Xiaoyue Ding, Xiaorui He, Ning Tian, Peng Ding, Wei Guo, Oseweuba Valentine Okoro, Yanfang Sun, Guohua Jiang, Zhenzhong Liu, and et al. 2024. "Fabrication and Properties of Hydrogel Dressings Based on Genipin Crosslinked Chondroitin Sulfate and Chitosan" Polymers 16, no. 20: 2876. https://doi.org/10.3390/polym16202876

APA Style

Wang, L., Ding, X., He, X., Tian, N., Ding, P., Guo, W., Okoro, O. V., Sun, Y., Jiang, G., Liu, Z., Shavandi, A., & Nie, L. (2024). Fabrication and Properties of Hydrogel Dressings Based on Genipin Crosslinked Chondroitin Sulfate and Chitosan. Polymers, 16(20), 2876. https://doi.org/10.3390/polym16202876

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