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Cells
Volume 10
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10.3390/cells10051170
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Review

Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy

by
Mithunah Krishnamoorthy
1,2,†,
Lara Gerhardt
1,2,† and
Saman Maleki Vareki
1,2,3,*
1
Cancer Research Laboratory Program, Lawson Health Research Institute, London, ON N6A5 W9, Canada
2
Department of Pathology and Laboratory Medicine, University of Western Ontario, London, ON N6A 3K7, Canada
3
Department of Oncology, Division of Experimental Oncology, University of Western Ontario, London, ON N6A 3K7, Canada
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2021, 10(5), 1170; https://doi.org/10.3390/cells10051170
Submission received: 30 March 2021 / Revised: 1 May 2021 / Accepted: 7 May 2021 / Published: 11 May 2021
(This article belongs to the Special Issue Immunosuppressive Myeloid Cells in Cancer and Pathophysiological Conditions)
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Abstract

The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells develop into myeloid-derived suppressor cells (MDSCs) that play a prominent role in suppressing anti-tumor immunity. Overcoming the suppressive effects of MDSCs is a major hurdle in cancer immunotherapy. Therefore, understanding the mechanisms by which MDSCs promote tumor growth is essential for improving current immunotherapies and developing new ones. This review explores mechanisms by which MDSCs suppress T-cell immunity and how this impacts the efficacy of commonly used immunotherapies.
Keywords: immunotherapy; MDSCs; T-cells; anti-PD-1; cancer; tumors immunotherapy; MDSCs; T-cells; anti-PD-1; cancer; tumors

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MDPI and ACS Style

Krishnamoorthy, M.; Gerhardt, L.; Maleki Vareki, S. Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy. Cells 2021, 10, 1170. https://doi.org/10.3390/cells10051170

AMA Style

Krishnamoorthy M, Gerhardt L, Maleki Vareki S. Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy. Cells. 2021; 10(5):1170. https://doi.org/10.3390/cells10051170

Chicago/Turabian Style

Krishnamoorthy, Mithunah, Lara Gerhardt, and Saman Maleki Vareki. 2021. "Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy" Cells 10, no. 5: 1170. https://doi.org/10.3390/cells10051170

APA Style

Krishnamoorthy, M., Gerhardt, L., & Maleki Vareki, S. (2021). Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy. Cells, 10(5), 1170. https://doi.org/10.3390/cells10051170

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