Soluble ST2 Receptor: Biomarker of Left Ventricular Impairment and Functional Status in Patients with Inflammatory Cardiomyopathy
Abstract
:1. Introduction
2. Methods
2.1. Study Design
2.2. Endomyocardial Biopsy and Immunohistochemical Analysis
2.3. CMR Imaging
2.4. sST2 Assay
2.5. NT-proBNP, CK-MB, and Troponin T
2.6. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Clinical Variable | All Patients | Inflammatory Cardiomyopathy (n = 60) | Dilated Cardiomyopathy (n = 29) | p Value |
---|---|---|---|---|
Age (years, mean ± SD) | 46 ± 15 | 47 ± 15 | 43 ± 14 | 0.77 |
Female (%) | 26 | 28 | 24 | 0.68 |
BMI (kg/m2) | 31 | 32 | 31 | 0.71 |
NYHA class at presentation (% of patients) | 0.85 | |||
NYHA class I/II | 66 | 63 | 71 | |
NYHA class III/IV | 34 | 37 | 29 | |
CMR findings | ||||
T2-weghted edema of LV (% of patients) | 11 | 11 | 11 | 0.43 |
EGE of LV (% of patients) | 63 | 69 | 44 | 0.01 |
LGE of LV (% of LV) | 13 ± 8 | 13 ± 7 | 12 ± 7 | 0.88 |
Echocardiography findings | ||||
LV-EF (%, mean ± SD) | 37 ± 16 | 36 ± 14 | 35 ± 20 | 0.69 |
LVEDD (mm, mean ± SD) | 162 ± 70 | 154 ± 58 | 180 ± 91 | 0.76 |
LVESD (mm, mean ± SD) | 106 ± 64 | 102 ± 54 | 116 ± 85 | 0.22 |
Biomarkers (plasma concentration) | ||||
sST2 (ng/mL; mean ± SD) | 45 ± 26 | 46 ± 29 | 44 ± 19 | 0.48 |
NT-proBNP (pg/mL; mean ± SD) | 2866 ± 5010 | 3208 ± 5726 | 1994 ± 2255 | 0.09 |
CK-MB (U/L; mean ± SD) | 64 ± 324 | 30 ± 35 | 135 ± 564 | 0.01 |
hsCRP (mg/L; mean ± SD) | 26 ± 40 | 29 ± 43 | 19 ± 32 | 0.08 |
Myoglobin (µg/L; mean ± SD) | 217 ± 260 | 198 ± 271 | 269 ± 228 | 0.61 |
Troponin T (ng/L; mean ± SD) | 202 ± 539 | 269 ± 643 | 64 ± 111 | 0.009 |
Immunohistochemistry (left ventricle) | ||||
CD3+ T cells (cells/cm2 ± SD) | 11 ± 13 | 14 ± 14 | 3 ± 2 | 0.001 |
CD68+ macrophages (cells/cm2 ± SD) | 25 ± 19 | 31 ± 20 | 11 ± 5 | 0.009 |
Enhanced MHC class II expression (n, %) | - | 60 (100) | 5 (18) | 0.001 |
Viral genome in EMB | ||||
EBV (%) | 12 | 14 | - | 0.001 |
HSV6/HSV7 (%) | 20 | 21 | - | 0.001 |
Parvovirus B19 (%) | 5 | 4 | - | 0.001 |
Enhanced MHC class II expression (%) | 64 | 100 | 19 | 0.001 |
Cardiovascular risk factors | ||||
History of Hypertension (%) | 59 | 56 | 64 | 0.48 |
History of Diabetes (%) | 11 | 11 | 10 | 0.97 |
Tobacco use (%) | 42 | 40 | 46 | 0.57 |
Functional Class NYHA III/IV at 12 Months | ||||||
Inflammatory Cardiomyopathy | Dilated Cardiomyopathy | |||||
Variables | Odds-Ratio | CI 95% | p | Odds-Ratio | CI 95% | p |
sST2 (ng/mL) | 1.21 | 1.01–1.30 | 0.02 | 0.92 | 0.80–1.06 | 0.28 |
LLC (≥2) | 0.92 | 0.27–3.15 | 0.90 | 1.10 | 0.30–8.79 | 0.95 |
NT-pro-BNP (pg/mL) | 1.01 | 1.0–1.11 | 0.57 | 1.00 | 0.99–1.01 | 0.27 |
Troponin-T (ng/L) | 0.99 | 0.98–1.01 | 0.44 | 0.94 | 0.93–1.02 | 0.30 |
CardiovascularOutcome at 12 Months (Cardiovascular Mortality, Malignant Arrhythmias/ICD Implantation, Hospitalization Due to Heart Failure) | ||||||
Inflammatory Cardiomyopathy | Dilated Cardiomyopathy | |||||
Variables | Odds-Ratio | CI 95% | p | Odds-Ratio | CI 95% | p |
sST2 (ng/mL) | 1.02 | 0.99–1.10 | 0.15 | 1.01 | 0.92–1.11 | 0.81 |
LLC (≥2) | 0.81 | 0.21–3.18 | 0.76 | 2.01 | 0.28–5.54 | 0.31 |
NT-pro-BNP (pg/mL) | 0.99 | 0.98–1.01 | 0.83 | 1.00 | 0.99–1.03 | 0.75 |
Troponin-T (ng/L) | 0.99 | 0.98–1.01 | 0.56 | 0.99 | 0.95–1.01 | 0.61 |
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Obradovic, D.M.; Büttner, P.; Rommel, K.-P.; Blazek, S.; Loncar, G.; von Haehling, S.; von Roeder, M.; Lücke, C.; Gutberlet, M.; Thiele, H.; et al. Soluble ST2 Receptor: Biomarker of Left Ventricular Impairment and Functional Status in Patients with Inflammatory Cardiomyopathy. Cells 2022, 11, 414. https://doi.org/10.3390/cells11030414
Obradovic DM, Büttner P, Rommel K-P, Blazek S, Loncar G, von Haehling S, von Roeder M, Lücke C, Gutberlet M, Thiele H, et al. Soluble ST2 Receptor: Biomarker of Left Ventricular Impairment and Functional Status in Patients with Inflammatory Cardiomyopathy. Cells. 2022; 11(3):414. https://doi.org/10.3390/cells11030414
Chicago/Turabian StyleObradovic, Danilo Momira, Petra Büttner, Karl-Philipp Rommel, Stephan Blazek, Goran Loncar, Stephan von Haehling, Maximilian von Roeder, Christian Lücke, Matthias Gutberlet, Holger Thiele, and et al. 2022. "Soluble ST2 Receptor: Biomarker of Left Ventricular Impairment and Functional Status in Patients with Inflammatory Cardiomyopathy" Cells 11, no. 3: 414. https://doi.org/10.3390/cells11030414
APA StyleObradovic, D. M., Büttner, P., Rommel, K. -P., Blazek, S., Loncar, G., von Haehling, S., von Roeder, M., Lücke, C., Gutberlet, M., Thiele, H., Lurz, P., & Besler, C. (2022). Soluble ST2 Receptor: Biomarker of Left Ventricular Impairment and Functional Status in Patients with Inflammatory Cardiomyopathy. Cells, 11(3), 414. https://doi.org/10.3390/cells11030414