Dissecting miRNA–Gene Networks to Map Clinical Utility Roads of Pharmacogenomics-Guided Therapeutic Decisions in Cardiovascular Precision Medicine
Abstract
:1. Introduction
2. Role of miRNAs in Cardiovascular System Physiology and Pathophysiology
3. Clinical Relevance of miRNA Networks in the Clinical Practice of CVDs
4. Experimental Data Collection of miRNA CVD Biomarkers and Bioinformatic Analysis
5. Atherosclerosis
6. Cardiomyopathy
7. Lipid Metabolism Disorder
8. The Clinical Implementation of the Biomarker miRNA Networks in the CVD Cluster of Atherosclerosis and Coronary Artery Disease
9. The Clinical Implementation of the Biomarker miRNA Networks in the CVD Cluster of Cardiomyopathy and Heart Failure
10. The Clinical Implementation of the Biomarker miRNA Networks in the CVD Cluster of Lipid Metabolism Disorders
11. Discussion
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Mature_Mirna | Targeted Genes | SNPs | Drugs | Disease_Drug | |
---|---|---|---|---|---|
1 | miR-155-5p | 241 | 5 | 15 | Cardiac hypertrophy; hypertension |
2 | miR-21-5p | 153 | 4 | 11 | Myocardial infarction; heart failure; vascular disease; cardiac hypertrophy; cardiomyopathy, dilated; stroke |
3 | miR-145-5p | 151 | 3 | 9 | Vascular disease; supravalvar aortic stenosis |
4 | miR-34a-5p | 148 | 4 | 31 | Stroke |
5 | miR-125b-5p | 126 | 5 | 4 | Cardiac hypertrophy; heart failure; vascular disease; cardiomyopathy, dilated; supravalvar aortic stenosis; cardiovascular; cardiomyopathy, idiopathic dilated; stroke |
6 | miR-29a-3p | 123 | 7 | 28 | Cardiac hypertrophy; cardiomyopathy, dilated; stroke |
7 | miR-24-3p | 110 | 4 | 1 | Cardiac hypertrophy; heart failure; cardiovascular; cardiomyopathy, dilated; supravalvar aortic stenosis; stroke |
8 | miR-29b-3p | 109 | 6 | 15 | Cardiac hypertrophy; myocardial infarction; cardiomyopathy, dilated; stroke |
9 | miR-200c-3p | 98 | 3 | 5 | Cardiomyopathy, dilated |
10 | miR-17-5p | 95 | 3 | 8 | Cardiomyopathy, dilated; stroke |
Atherosclerosis | Cardiomyopathy | Lipid Metabolism Disorder | ||||
---|---|---|---|---|---|---|
Mature_Mirna | Targeted Genes | Mature_Mirna | Targeted Genes | Mature_Mirna | Targeted Genes | |
1 | miR-146a-5p * | 18 | miR-21-5p | 10 | miR-138-5p * | 8 |
2 | miR-155-5p | 15 | miR-24-3p | 9 | miR-146a-5p * | 6 |
3 | miR-21-5p | 15 | miR-145-5p | 7 | miR-26a-5p * | 5 |
4 | miR-24-3p | 15 | miR-138-5p * | 7 | miR-27a-3p * | 5 |
5 | miR-29b-3p | 13 | miR-143-3p * | 7 | miR-145-5p | 5 |
6 | miR-143-3p * | 12 | miR-17-5p | 7 | miR-130a-3p * | 5 |
7 | miR-145-5p | 12 | miR-155-5p | 6 | miR-98-5p * | 5 |
8 | miR-221-3p * | 12 | miR-125b-5p | 6 | miR-130b-3p * | 5 |
9 | miR-126-3p * | 11 | miR-146a-5p * | 6 | miR-223-3p * | 4 |
10 | miR-138-5p * | 11 | miR-133b * | 5 | miR-1-3p * | 4 |
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Chatzopoulou, F.; Kyritsis, K.A.; Papagiannopoulos, C.I.; Galatou, E.; Mittas, N.; Theodoroula, N.F.; Papazoglou, A.S.; Karagiannidis, E.; Chatzidimitriou, M.; Papa, A.; et al. Dissecting miRNA–Gene Networks to Map Clinical Utility Roads of Pharmacogenomics-Guided Therapeutic Decisions in Cardiovascular Precision Medicine. Cells 2022, 11, 607. https://doi.org/10.3390/cells11040607
Chatzopoulou F, Kyritsis KA, Papagiannopoulos CI, Galatou E, Mittas N, Theodoroula NF, Papazoglou AS, Karagiannidis E, Chatzidimitriou M, Papa A, et al. Dissecting miRNA–Gene Networks to Map Clinical Utility Roads of Pharmacogenomics-Guided Therapeutic Decisions in Cardiovascular Precision Medicine. Cells. 2022; 11(4):607. https://doi.org/10.3390/cells11040607
Chicago/Turabian StyleChatzopoulou, Fani, Konstantinos A. Kyritsis, Christos I. Papagiannopoulos, Eleftheria Galatou, Nikolaos Mittas, Nikoleta F. Theodoroula, Andreas S. Papazoglou, Efstratios Karagiannidis, Maria Chatzidimitriou, Anna Papa, and et al. 2022. "Dissecting miRNA–Gene Networks to Map Clinical Utility Roads of Pharmacogenomics-Guided Therapeutic Decisions in Cardiovascular Precision Medicine" Cells 11, no. 4: 607. https://doi.org/10.3390/cells11040607
APA StyleChatzopoulou, F., Kyritsis, K. A., Papagiannopoulos, C. I., Galatou, E., Mittas, N., Theodoroula, N. F., Papazoglou, A. S., Karagiannidis, E., Chatzidimitriou, M., Papa, A., Sianos, G., Angelis, L., Chatzidimitriou, D., & Vizirianakis, I. S. (2022). Dissecting miRNA–Gene Networks to Map Clinical Utility Roads of Pharmacogenomics-Guided Therapeutic Decisions in Cardiovascular Precision Medicine. Cells, 11(4), 607. https://doi.org/10.3390/cells11040607