The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors
Abstract
:1. Introduction
2. The Plot
2.1. Setting the Scene: The NuRD Complex
2.2. Finding the Location: NuRD Complex in Developing and Adult Neurons
2.3. An Interesting Twist in the Plot: The Assembly of the NuRD Complex
2.4. When the Good Cop Becomes the Bad Cop: CHDs and Neurodevelopmental Disorders
3. Waiting for the Sequel
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Gene | Neurodevelopmental Disorders |
---|---|
NuRD Subunits | |
CHD3 | Craniofacial defects, developmental delay, language deficits (Snijders Blok–Campeau syndrome) [50] |
CHD4 | Developmental delay, speech and motor delay, cognitive impairment (Sifrim–Hitz–Weiss syndrome) [51,52] |
CHD5 | Language deficits, intellectual disability, epilepsy, behavioural disorder (Parenti–Mignot neurodevelopmental syndrome) [53] |
GATAD2B | Motor disability, intellectual disability, language deficits, developmental delay, craniofacial abnormalities (GATAD2B-associated neurodevelopmental disorder) [54] |
MBD3 | Non-verbal ASD [55,56] |
Other CHDs | |
CHD2 | Epilepsy, neurobehavioural disorders, intellectual disability [57,58] |
CHD7 | Intellectual disability, hearing and visual impairments, developmental delay, self-injurious behaviour, sleep problems (CHARGE syndrome) [59,60,61] |
CHD8 | Developmental delay, ASD, behavioural disorder, musculoskeletal defects (Intellectual developmental disorder with autism and macrocephaly, IDDAM) [62,63,64] |
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Boulasiki, P.; Tan, X.W.; Spinelli, M.; Riccio, A. The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors. Cells 2023, 12, 1179. https://doi.org/10.3390/cells12081179
Boulasiki P, Tan XW, Spinelli M, Riccio A. The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors. Cells. 2023; 12(8):1179. https://doi.org/10.3390/cells12081179
Chicago/Turabian StyleBoulasiki, Paraskevi, Xiao Wei Tan, Matteo Spinelli, and Antonella Riccio. 2023. "The NuRD Complex in Neurodevelopment and Disease: A Case of Sliding Doors" Cells 12, no. 8: 1179. https://doi.org/10.3390/cells12081179