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Cells
Volume 12
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10.3390/cells12081181
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Review

Advanced 3D Models of Human Brain Tissue Using Neural Cell Lines: State-of-the-Art and Future Prospects

by
Rachele Fabbri
1,2,
Ludovica Cacopardo
1,2,3,
Arti Ahluwalia
1,2,3,* and
Chiara Magliaro
1,2,3
1
Research Center “E. Piaggio”, University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy
2
Department of Information Engineering (DII), University of Pisa, Via G. Caruso 16, 56122 Pisa, Italy
3
Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Italy
*
Author to whom correspondence should be addressed.
Cells 2023, 12(8), 1181; https://doi.org/10.3390/cells12081181
Submission received: 13 February 2023 / Revised: 12 April 2023 / Accepted: 14 April 2023 / Published: 18 April 2023
(This article belongs to the Special Issue Neural Stem Cells: Developmental Mechanisms and Disease Modelling)
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Abstract

Human-relevant three-dimensional (3D) models of cerebral tissue can be invaluable tools to boost our understanding of the cellular mechanisms underlying brain pathophysiology. Nowadays, the accessibility, isolation and harvesting of human neural cells represents a bottleneck for obtaining reproducible and accurate models and gaining insights in the fields of oncology, neurodegenerative diseases and toxicology. In this scenario, given their low cost, ease of culture and reproducibility, neural cell lines constitute a key tool for developing usable and reliable models of the human brain. Here, we review the most recent advances in 3D constructs laden with neural cell lines, highlighting their advantages and limitations and their possible future applications.
Keywords: in vitro advanced brain models; neuroblastoma cell lines; glioblastoma cell lines in vitro advanced brain models; neuroblastoma cell lines; glioblastoma cell lines
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MDPI and ACS Style

Fabbri, R.; Cacopardo, L.; Ahluwalia, A.; Magliaro, C. Advanced 3D Models of Human Brain Tissue Using Neural Cell Lines: State-of-the-Art and Future Prospects. Cells 2023, 12, 1181. https://doi.org/10.3390/cells12081181

AMA Style

Fabbri R, Cacopardo L, Ahluwalia A, Magliaro C. Advanced 3D Models of Human Brain Tissue Using Neural Cell Lines: State-of-the-Art and Future Prospects. Cells. 2023; 12(8):1181. https://doi.org/10.3390/cells12081181

Chicago/Turabian Style

Fabbri, Rachele, Ludovica Cacopardo, Arti Ahluwalia, and Chiara Magliaro. 2023. "Advanced 3D Models of Human Brain Tissue Using Neural Cell Lines: State-of-the-Art and Future Prospects" Cells 12, no. 8: 1181. https://doi.org/10.3390/cells12081181

APA Style

Fabbri, R., Cacopardo, L., Ahluwalia, A., & Magliaro, C. (2023). Advanced 3D Models of Human Brain Tissue Using Neural Cell Lines: State-of-the-Art and Future Prospects. Cells, 12(8), 1181. https://doi.org/10.3390/cells12081181

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