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Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target
 
 
Review
Peer-Review Record

Viral Targeting of Importin Alpha-Mediated Nuclear Import to Block Innate Immunity

by Olivia A. Vogel 1, Jade K. Forwood 2, Daisy W. Leung 3, Gaya K. Amarasinghe 4 and Christopher F. Basler 1,*
Reviewer 1:
Reviewer 2: Anonymous
Submission received: 25 November 2023 / Revised: 22 December 2023 / Accepted: 27 December 2023 / Published: 29 December 2023

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The manuscript by Vogel et al provides a detailed overview of the literature on viral mechanisms of immune evasion that target importin-alpha (IMPA) to impede nuclear translocation of key host transcription factors. It is very well written and thoroughly cites the pertinent sources. The manuscript will be of broad interest to researchers studying viral inhibition of the type I  interferon and innate immune responses. I have only a few minor suggestions and comments as outlined below.

 

Line 64: I appreciate the effort made to explain why IMPA2 is missing, but still found this explanation unclear.

 

Line 106- ‘of NFKB’?

 

In the overview of IFN signaling include mention of ISGF3 (STAT1/2 and IRF9) as the complex that is ultimately imported into the nucleus.

 

Line 171- The text following the end of this line is missing.

 

Line 202- define NPI-1

Author Response

We thank the reviewer for the useful comments. Please see our attached responses.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

see attached file

Comments for author File: Comments.pdf

Author Response

We thank the reviewer for the useful comments. Please see our attached responses.

Author Response File: Author Response.pdf

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