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Open AccessReview
The Structures, Functions, and Roles of Class III HDACs (Sirtuins) in Neuropsychiatric Diseases
by
Robin E. Bonomi
Robin E. Bonomi 1,*,
William Riordan
William Riordan 1 and
Juri G. Gelovani
Juri G. Gelovani 2,3,4
1
Department of Psychiatry, Yale University, New Haven, CT 06511, USA
2
College of Medicine and Health Sciences, Office of the Provost, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates
3
Department of Biomedical Engineering, College of Engineering and School of Medicine, Wayne State University, Detroit, MI 48201, USA
4
Department of Radiology, Division of Nuclear Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
*
Author to whom correspondence should be addressed.
Cells 2024, 13(19), 1644; https://doi.org/10.3390/cells13191644 (registering DOI)
Submission received: 19 August 2024
/
Revised: 29 September 2024
/
Accepted: 30 September 2024
/
Published: 2 October 2024
Abstract
Over the past two decades, epigenetic regulation has become a rapidly growing and influential field in biology and medicine. One key mechanism involves the acetylation and deacetylation of lysine residues on histone core proteins and other critical proteins that regulate gene expression and cellular signaling. Although histone deacetylases (HDACs) have received significant attention, the roles of individual HDAC isoforms in the pathogenesis of psychiatric diseases still require further research. This is particularly true with regard to the sirtuins, class III HDACs. Sirtuins have unique functional activity and significant roles in normal neurophysiology, as well as in the mechanisms of addiction, mood disorders, and other neuropsychiatric abnormalities. This review aims to elucidate the differences in catalytic structure and function of the seven sirtuins as they relate to psychiatry.
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MDPI and ACS Style
Bonomi, R.E.; Riordan, W.; Gelovani, J.G.
The Structures, Functions, and Roles of Class III HDACs (Sirtuins) in Neuropsychiatric Diseases. Cells 2024, 13, 1644.
https://doi.org/10.3390/cells13191644
AMA Style
Bonomi RE, Riordan W, Gelovani JG.
The Structures, Functions, and Roles of Class III HDACs (Sirtuins) in Neuropsychiatric Diseases. Cells. 2024; 13(19):1644.
https://doi.org/10.3390/cells13191644
Chicago/Turabian Style
Bonomi, Robin E., William Riordan, and Juri G. Gelovani.
2024. "The Structures, Functions, and Roles of Class III HDACs (Sirtuins) in Neuropsychiatric Diseases" Cells 13, no. 19: 1644.
https://doi.org/10.3390/cells13191644
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