State-of-the-Art Research on Histone Deacetylases (HDACs) and Histone Acetyltransferases (HATs)
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".
Deadline for manuscript submissions: 15 June 2025 | Viewed by 1064
Special Issue Editor
Interests: histone deacetylases (HDACs); DNA damage response; DNA repair; cell cycle checkpoint; E3 ligases; deubiquitinating enzymes (DUBs); lung cancer; chemoresistance; immunotherapy and cancer immunology
Special Issue Information
Dear Colleagues,
We are thrilled to present a Special Issue in Cells dedicated to the captivating realm of histone deacetylases and histone acetyltransferases.
Histone deacetylases (HDACs) and histone acetyltransferases (HATs) are two classes of enzymes catalyzing deacetylation and acetylation on lysine residues of core histones as well as non-histone proteins. HDACs include three Zn+-dependent HDAC families and an NAD+-dependent Sirtuin family. Recently, at least eight acylation modifications have been identified on lysine residues, such as crotonylation, malonylation, succinylation, glutarylation, etc. Interestingly, HDACs and HATs could serve as “erasers” and “writers” for some of these newly identified modifications. Therefore, HDACs and HATs may aptly be named lysine deacylases and lysine acyltransferases.
Both HDACs and HATs play important roles in almost all biological processes, such as gene expression, cell differentiation, apoptosis, metabolism, and immune responses. Both HDAC inhibitors and HAT inhibitors are used for the targeted therapy of tumors, inhibiting cell growth and promoting cell differentiation as well as apoptosis. The inhibition of HDACs or HATs has become an important approach to reverse the abnormal epigenetic and signaling changes associated with various cancers and non-cancer diseases.
We invite researchers, scholars, and experts from around the world to contribute their valuable insights to this Special Issue. By presenting your work on the role and involvement of HDACs and HATs in diseases, you have the opportunity to contribute to advancing our understanding of histone deacetylases and histone acetyltransferases.
We look forward to your contributions.
Dr. Xiaohong Zhang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- histone deacetylases
- cancer
- metabolism
- immunotherapy
- tumor microenvironment
- DNA damage response
- cell cycle
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
