Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis
Abstract
:1. Introduction
2. The Nucleolus and Stress
2.1. Nucleolar Maintenance of Cell Physiology
2.2. p53 Dependent and Independent Consequences of Nucleolar Stress
3. TIF-IA-NF-κB Nucleolar Stress
3.1. Stress Activation of the NF-κB Pathway
3.2. TIF-IA Degradation—A Novel Form of Nucleolar Stress
3.3. Nucleolar Enlargement as a Consequence of TIF-IA Degradation
3.4. Activation of the NF-κB Pathway as a Consequence of TIF-IA Degradation
3.5. TIF-IA-NF-κB Nucleolar Stress and the Induction of Apoptosis
4. Nucleolar Sequestration of RelA and Apoptosis
5. Therapeutic Relevance of Crosstalk between Nucleoli and the NF-κB Pathway
6. Summary
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Chen, J.; Stark, L.A. Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis. Cells 2018, 7, 157. https://doi.org/10.3390/cells7100157
Chen J, Stark LA. Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis. Cells. 2018; 7(10):157. https://doi.org/10.3390/cells7100157
Chicago/Turabian StyleChen, Jingyu, and Lesley A. Stark. 2018. "Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis" Cells 7, no. 10: 157. https://doi.org/10.3390/cells7100157