Endoplasmic Reticulum Stress in Metabolic Disorders
Abstract
:1. ER Functions and Homeostasis
1.1. The Multiple Functions of ER in Protein, Lipid, and Calcium Homeostasis
1.2. ER Interconnections with Other Organelles
2. ER Stress and the Unfolded Protein Response (UPR)
2.1. The UPR
2.2. ER Senses Cell Stress and Integrates Metabolic Stress Signals
3. ER Stress Induces IR and Diabetes
3.1. Importance of the ER in IR and Diabetes
3.2. Inflammatory Response
3.3. Lipotoxicity
3.4. Glucotoxicity
3.5. Insulin Receptor Modulation
3.6. Mechanisms Specific to Liver Cells: Activation of Gluconeogenesis and Lipogenesis
3.7. Mechanisms Specific to Beta-Cells: Accumulation of Proinsulin and Amyloid Deposits in the ER
3.8. Brain-Specific Mechanisms: Leptin Resistance
4. ER and Fatty Liver Disease
4.1. Oxidative Stress
4.2. Disturbance of Lipid Metabolism
4.3. Inflammation
4.4. Apoptosis
4.5. Autophagy
5. ER Stress and Atherosclerosis
5.1. ER Stress in Macrophages
5.2. ER Stress in Endothelial Cells (ECs)
5.3. ER Stress in Vascular Smooth Muscle Cells
6. Therapeutic Intervention on ER Stress in Metabolic Diseases
6.1. Regulators of ER Calcium Homeostasis
6.2. Non-Specific Protein Misfolding Inhibitors
6.3. Bip Activators
6.4. Regulators of the PERK/eIF2α/ATF4/CHOP Branch
6.5. Regulators of the IRE1α/XBP1 Branch
6.6. Regulators of the ATF6 Branch
7. General Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
4-PBA | 4-phenylbutyrate |
ALDH | Aldehyde dehydrogenase |
AMPK | AMP-activated protein kinase |
AP1 | Activator protein 1 |
ApoE | Apolipoprotein E |
ASK1 | Apoptosis signal-regulating kinase |
ATF | Activating transcription factor |
ATP | Adenosine triphosphate |
BCL | B-cell lymphoma |
BI-1 | Bax inhibitor-1 (BI-1) |
C/EBP | CCAAT/enhancer-binding protein |
CD36 | cluster of differentiation 36 |
CNPY2 | Canopy homolog 2 |
CREBH | Cyclic AMP-responsive element binding protein, hepatocyte-specific |
Cyt c | Cytochrome c |
DKK1 | Dickkopf1 |
ECs | Endothelial cells |
eIF2α | Eukaryotic initiation factor 2α |
ER | Endoplasmic Reticulum |
ERAD | ER-associated degradation |
FA | Fatty acids |
FDA | Food and Drug Administration |
FGF21 | Fibroblast growth factor 21 |
FOXO1 | Forkhead box protein O1 |
GABA | Gamma-Aminobutyric acid |
GADD153 or CHOP | C/EBPα-homologous protein |
GLUT | glucose transporter |
GM-CSF | Granulocyte macrophage colony stimulating factor |
GRP78 | 78 KDa glucose-regulated proteins |
GSIS | Glucose-stimulated insulin secretion |
GSK | Glycogen synthase kinase |
HDAC | Histone deacetylases |
Herpud1 | Homocysteine inducible ER protein with ubiquitin like domain 1 |
HFD | High fat diet |
hIAPP | Human islet amyloid polypeptide |
HNAs | Hydroxynaphthoic acids |
HNF4α | Hepatocyte nuclear factor 4 |
HSPA5 | Heat shock 70 kDa protein 5 |
HUVECs | Human umbilical vein endothelial cells |
IAPP | Islet amyloid polypeptide |
IFN-γ | Interferon gamma |
IGF1 | Insulin-like growth factor 1 |
IKKβ | IκB kinase β |
IL | interleukin |
iNOS | Inducible nitric oxide synthase |
INS1 cells | Insulin-secreting cell lines |
IP3Rs | Inositol trisphosphate receptors |
IR | Insulin resistance |
IRE1α | Inositol- requiring enzyme 1α |
IRS-1 | Insulin receptor substrate-1 |
ISRIB | Integrated stress response inhibitor |
JAK | Janus kinase |
JNK | JUN N-terminal kinase |
LDL | Low density lipoprotein |
LPS | Lipopolysaccharide |
MAM | Mitochondria-associated ER membrane |
MAPK | Mitogen-activated protein kinase |
MIDY | Mutant insulin INS gene-induced diabetes of youth |
mTORC1 | Mammalian target of rapamycin complex 1 |
NADPH | Nicotinamide adenine dinucleotide phosphate |
NAFLD | Non-alcoholic fatty liver disease |
NASH | Non-alcoholic steatohepatitis |
Nfe2L1 | Nuclear factor erythroid 2 like 1 |
NFκB | Nuclear factor κB |
NLRP | NOD-like receptor family and pyrin domain |
NO | Nitric oxide |
NOX4 | NADPH oxidase 4 |
Nrf1 | Nuclear respiratory factor 1 |
PBMCs | Peripheral blood monocytes |
PC | Phosphatidylcholine |
PDI | Protein disulfide isomerase |
PE | Phosphatidylethanolamine |
PERK | RNA-dependent protein kinase (PKR)-like ER kinase |
PGC-1α | Peroxisome proliferator-activated receptor gamma coactivator 1 alpha |
PKA | Protein kinase A |
PKC | protein kinase C |
PM | Plasma membrane |
PMCA | Plasma membrane Ca2+ ATPase |
POMC | Pro-opiomelanocortin |
PPARγ | Peroxisome proliferator-activated receptor γ |
PVAT | Perivascular adipose tissue |
RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 |
RORα | receptor-related orphan receptor α |
ROS | Reactive oxygen species |
SERCA | Sarco-endoplasmic reticulum Ca(2+)-ATPase |
SIRT3 | Sirtuin-3 |
SPCA | Secretory Pathway Calcium ATPase |
SREBP | Sterol regulatory element-binding protein |
STAT | Signal transducer and activator of transcription |
T1D | Type 1 diabetes |
T2DM | Type 2 diabetes mellitus |
TA | Transactivation domain |
TCA cycle | Tricarboxylic acid cycle |
TLR2 | Toll-like Receptor 2 |
TMAO | Trimethylamine N-oxide |
TNFα | Tumor necrosis factor alpha |
TRAF2 | TNF receptor–associated factor 2 |
TUDCA | Tauroursodeoxycholic acid |
uORF | Upstream Open Reading Frame |
UPR | Unfolded protein response |
VLDL | Very low-density lipoprotein |
VLDLR | VLDL receptor |
VSMCs | Vascular smooth muscle cells |
XBP1 | X-box binding protein 1 |
YAP1 | Yes-associated protein 1 |
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Ghemrawi, R.; Battaglia-Hsu, S.-F.; Arnold, C. Endoplasmic Reticulum Stress in Metabolic Disorders. Cells 2018, 7, 63. https://doi.org/10.3390/cells7060063
Ghemrawi R, Battaglia-Hsu S-F, Arnold C. Endoplasmic Reticulum Stress in Metabolic Disorders. Cells. 2018; 7(6):63. https://doi.org/10.3390/cells7060063
Chicago/Turabian StyleGhemrawi, Rose, Shyue-Fang Battaglia-Hsu, and Carole Arnold. 2018. "Endoplasmic Reticulum Stress in Metabolic Disorders" Cells 7, no. 6: 63. https://doi.org/10.3390/cells7060063