The Interplay among Subunit Composition, Cardiolipin Content, and Aggregation State of Bovine Heart Cytochrome c Oxidase
Abstract
:1. Introduction
1.1. Specific Cardiolipin Interactions with CcO Surface
1.2. Nonspecific Entropic Effect of Phospholipids on Dimerization of Membrane Proteins
1.3. Specific Protein–Lipid and Protein–Protein Interactions in Dimerization of Membrane Proteins
2. Role of Amphiphilic Environment in Aggregation State of Cytochrome c Oxidase
2.1. Evidence for Existence of Dimeric Structure of CcO
2.2. Modulation of the Aggregation State of CcO by “Linear” Detergents
2.3. Dimerization of CcO Induced by “Planar” Bile Salt Detergents
3. Role of Interface Subunits and Cardiolipin in Function and Stability of Cytochrome c Oxidase Dimeric Form
3.1. Role of Unspecific Phospholipids in Stabilization of Dimeric CcO
3.2. Relationship between Specific CL Binding/Dimerization and Proton Pumping of CcO
3.3. Evidences for a Monomeric Electron-Transfer Competing Form of CcO
3.4. Fast Labile Monomer versus Tunable Stable Dimer of CcO
4. Posttranslational Modifications in Cytochrome c Oxidase
5. Cytochrome c Oxidase in Supercomplexes of the Respiratory Chain
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sedlák, E.; Kožár, T.; Musatov, A. The Interplay among Subunit Composition, Cardiolipin Content, and Aggregation State of Bovine Heart Cytochrome c Oxidase. Cells 2020, 9, 2588. https://doi.org/10.3390/cells9122588
Sedlák E, Kožár T, Musatov A. The Interplay among Subunit Composition, Cardiolipin Content, and Aggregation State of Bovine Heart Cytochrome c Oxidase. Cells. 2020; 9(12):2588. https://doi.org/10.3390/cells9122588
Chicago/Turabian StyleSedlák, Erik, Tibor Kožár, and Andrey Musatov. 2020. "The Interplay among Subunit Composition, Cardiolipin Content, and Aggregation State of Bovine Heart Cytochrome c Oxidase" Cells 9, no. 12: 2588. https://doi.org/10.3390/cells9122588