Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke

Santopolo, Giuseppe; Magnusson, Jens P.; Lindvall, Olle; Kokaia, Zaal; Frisén, Jonas

doi:10.3390/cells9071732

Open AccessEditor’s ChoiceCommunication

Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke

by

Giuseppe Santopolo

¹,

Jens P. Magnusson

^1,†,

Olle Lindvall

²,

Zaal Kokaia

²

and

Jonas Frisén

^1,*

¹

Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden

²

Lund Stem Cell Center, University Hospital, SE-221 84 Lund, Sweden

^*

Author to whom correspondence should be addressed.

^†

Current affiliation: Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

Cells 2020, 9(7), 1732; https://doi.org/10.3390/cells9071732

Submission received: 13 June 2020 / Revised: 15 July 2020 / Accepted: 16 July 2020 / Published: 20 July 2020

(This article belongs to the Special Issue Neuron-Glia Interactions)

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Abstract

Stroke triggers neurogenesis in the striatum in mice, with new neurons deriving in part from the nearby subventricular zone and in part from parenchymal astrocytes. The initiation of neurogenesis by astrocytes within the striatum is triggered by reduced Notch-signaling, and blocking this signaling pathway by deletion of the gene encoding the obligate Notch coactivator Rbpj is sufficient to activate neurogenesis by striatal astrocytes in the absence of an injury. Here we report that blocking Notch-signaling in stroke increases the neurogenic response to stroke 3.5-fold in mice. Deletion of Rbpj results in the recruitment of a larger number of parenchymal astrocytes to neurogenesis and over larger areas of the striatum. These data suggest inhibition of Notch-signaling as a potential translational strategy to promote neuronal regeneration after stroke.

Keywords: neurogenesis; astrocyte; stem cell; stroke; striatum

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MDPI and ACS Style

Santopolo, G.; Magnusson, J.P.; Lindvall, O.; Kokaia, Z.; Frisén, J. Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke. Cells 2020, 9, 1732. https://doi.org/10.3390/cells9071732

AMA Style

Santopolo G, Magnusson JP, Lindvall O, Kokaia Z, Frisén J. Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke. Cells. 2020; 9(7):1732. https://doi.org/10.3390/cells9071732

Chicago/Turabian Style

Santopolo, Giuseppe, Jens P. Magnusson, Olle Lindvall, Zaal Kokaia, and Jonas Frisén. 2020. "Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke" Cells 9, no. 7: 1732. https://doi.org/10.3390/cells9071732

APA Style

Santopolo, G., Magnusson, J. P., Lindvall, O., Kokaia, Z., & Frisén, J. (2020). Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke. Cells, 9(7), 1732. https://doi.org/10.3390/cells9071732

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke

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