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Volume 12
Issue 10
10.3390/genes12101470
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Review
Peer-Review Record

Fungal Lysine Deacetylases in Virulence, Resistance, and Production of Small Bioactive Compounds

Genes 2021, 12(10), 1470; https://doi.org/10.3390/genes12101470
by Ingo Bauer and Stefan Graessle *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Genes 2021, 12(10), 1470; https://doi.org/10.3390/genes12101470
Submission received: 27 August 2021 / Accepted: 20 September 2021 / Published: 23 September 2021
(This article belongs to the Special Issue Human Fungal Pathogens and Emerging Antifungal Resistance—A Global Public Health Problem?)

Round 1

Reviewer 1 Report

The present review discuss about fungal Lysine Deacetylases (KDACs), and its implication in virulence, resistance and production of small bioactive compounds. In this context, the authors also bring to table the potential of KDACs as antifungal agents, and as tool to discover small compounds (produced by fungi) that have pharmaceutical properties. It is a relevant review for the fields, specially taking in consideration the increase not only of fungal infection worldwide, but also drug resistance between them. It allows the best of both worlds, fight fungal infection using fungal molecules. The review does a great job in explore how KDACs inhibitors could act in two segments: antifungal drug, and as tool to identify small bioactive compounds that can have pharmaceutical properties as well. Even the authors not mentioning it, I believe this review could be useful for the investigators that also work with fungal extracellular vesicles.

No comments, suggestion or modifications. The present review is clear, clean, rich in information, and the figures are right to the point.

Reviewer 2 Report

 In this review the authors an overview of the members of classical lysine deacetylases (KDACs) and their complexes in filamentous fungi. Further, was discussed the impact of genetic manipulation of KDACs on pathogenicity and the production of bioactive molecules. The authors also answer to the question about to what extent KDACs might indeed affect the virulence of pathogenic fungi and what insights their depletion has yielded so far regarding fungal virulence, as well as the impact of classical KDACs for fungal secondary metabolism production.
     This study is very important for the evolution of the studies concerning to inhibitors of these enzymes and their role as potential new antifungals and emerging tools for the discovery of novel pharmaceutical drugs and antibiotics in fungal producer strains. So, for this review, suggestions are not necessary.

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