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Article
Peer-Review Record

Analysis of CACNA1C and KCNH2 Risk Variants on Cardiac Autonomic Function in Patients with Schizophrenia

Genes 2022, 13(11), 2132; https://doi.org/10.3390/genes13112132
by Alexander Refisch 1,2,*, Shoko Komatsuzaki 3, Martin Ungelenk 3, Andy Schumann 2, Ha-Yeun Chung 4, Susann S. Schilling 2, Wibke Jantzen 2, Sabine Schröder 2, Markus M. Nöthen 5,6, Thomas W. Mühleisen 7,8,9, Christian A. Hübner 3 and Karl-Jürgen Bär 2
Reviewer 2: Anonymous
Genes 2022, 13(11), 2132; https://doi.org/10.3390/genes13112132
Submission received: 17 October 2022 / Revised: 8 November 2022 / Accepted: 12 November 2022 / Published: 16 November 2022
(This article belongs to the Special Issue Genetic Basis of Stress-Related Neuropsychiatric Disorders)

Round 1

Reviewer 1 Report

Hi Dears;

1-What is the reason for choosing DSM-IV diagnostic criterion? 

(The DSM-IV is old criterion and DSM-IV TR and DSM-5  are newer).

2-  Please specify the age range of the patients participating in the research.

(Considering that age is an important intervening variable in Heart diseases).

3- Ethical point: Explain the reason for discontinuing the medication of Schizophrenic patients for 8 weeks?

( Discontinuing the medication of a Schizophrenic patient, can cause the  disorder to relapse and increase the risk of behavioral disorders).

4-Explain more about ,how to sampling?

Author Response

Please see the attachment. Thank you for your comments!

Author Response File: Author Response.docx

Reviewer 2 Report

I just have minor revision for authors:

1) Authors need to generate a summary table for all variants very clear to understand. 

Author Response

Please see the attachment. Thank you for your comment!

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

Thanks for the corrections.

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