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Volume 13
Issue 3
10.3390/genes13030491
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Article
Peer-Review Record

Pleiotropic Effects of Common and Rare GCKR Exonic Mutations on Cardiometabolic Traits

Genes 2022, 13(3), 491; https://doi.org/10.3390/genes13030491
by Kuan-Hung Yeh 1,2,†, Lung-An Hsu 3,†, Ming-Sheng Teng 4, Semon Wu 5, Hsin-Hua Chou 1,2 and Yu-Lin Ko 1,2,4,*
Reviewer 1:
Han Naung Tun
Reviewer 2: Anonymous
Genes 2022, 13(3), 491; https://doi.org/10.3390/genes13030491
Submission received: 27 January 2022 / Revised: 4 March 2022 / Accepted: 6 March 2022 / Published: 10 March 2022
(This article belongs to the Section Human Genomics and Genetic Diseases)

Round 1

Reviewer 1 Report

The study about the Pleiotropic Effects of Common and Rare GCKR Exonic Mutations 2 on Cardiometabolic Traits is really interesting for readers and scientific communities . 

The study design and methodology sounds judged and good . In this study, you have presented lipid-related genetic variants with pleiotropic effects on other cardio-metabolic traits. 

Can you describe more about the increased use of genetic information in clinical practice, has underscored the importance of understanding pleiotropy and its implications for genetic testing and personal genomics ?

I have noticed that most studies have focused only on the detection of pleiotropic effects. It may be necessary to search for additional shared genetic patterns in Taiwanese on multiple phenotypes in larger sample sizes across diverse ethnic cohorts as well as in your population. 

What is new in your analysis in the population as the pleotrophic effect of these genetic mutation already known . Can you please also describe genetic variants among your Taiwanese biobank? 

By integrating biological knowledge , can you describe more information and data with genetic pleiotropy and environmental factors that could explain ‘missing heritability’ for phenotypic variance in Taiwanese population. 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

In this robust study, Yeh KH and colleagues described the pleiotropic effect of a common and five rare variants within exon 4 of the GCKR gene on cardiometabolic traits and hematological parameters. The authors also analyzed the cumulative effect of rare genetic variants (gene score). The genetic risk score can estimate the overall probability or risk a person has for developing an outcome of interest based on their genotypes at variants determined to be associated with risk for that outcome. All statistical analyses are well described.

Author Response

We greatly appreciate the expert recommendations of the reviewers.

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