Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature
Abstract
:1. Introduction
2. Methods
2.1. Search Strategy
2.2. Inclusion Criteria and Data Extraction
3. Results
3.1. Characteristics of Studies
3.2. Association of MTHFR (rs1801133) and HTN Reported in African Continent
4. Discussion
Strengths and Limitations of This Study
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Inclusion | Exclusion |
---|---|
Published from 1984 to 2021 | Studies conducted before 1983 |
Human studies | Non-human studies |
Reported data on the genotypes among cases and controls | No genotypes among cases and controls |
Studies reporting association between MTHFR polymorphisms (rs1801133) and HTN | Studies in gene expression |
Studies provided enough data to calculate ORs and 95% confidence interval | Studies provided not enough data to calculate ORs and 95% confidence interval |
Case-control design | Reviews |
Non-family-based studies | Family-based studies |
Author, Year | Association | Country | Ethnicity | Cases | Cases with SNP | Control | Controls with SNP | p-Value HWE |
---|---|---|---|---|---|---|---|---|
Africa | ||||||||
Ghogomu et al., 2016 [34] | Yes | Cameroon | Bantu | 41 | 38 | 50 | 5 | Yes |
Amrani-Midoun et al., 2016 [15,36] | No | Algeria | Caucasian | 82 | 45 | 72 | 28 | Yes |
Nassereddine et al., 2015 [16] | Yes | Morocco | Caucasian | 101 | 54 | 102 | 48 | Yes |
Amin et al., 2012 [35] | No | Egypt | Caucasian | 97 | 40 | 84 | 37 | Yes |
Asia | ||||||||
Arina et al., 2019 [37] | Yes | Indonesia | Asian | 53 | 21 | 53 | 10 | Yes |
Dwivedi et al., 2017 [38] | Yes | India | Asian | 100 | 29 | 223 | 39 | No |
Fan et al., 2016 [28] | Yes | China | Chinese | 214 | 177 | 494 | 375 | Yes |
Wen et al., 2015 [39] | Yes | China | Asian | 174 | 129 | 634 | 376 | Yes |
Wang et al., 2015 [40] | Yes | China | Asian | 190 | 94 | 287 | 143 | Yes |
Cai et al., 2014 [41] | Yes | China | Chinese | 200 | 161 | 200 | 139 | Yes |
Xi et al., 2013 [42] | Yes | China | Chinese | 619 | 378 | 2458 | 1376 | Yes |
Zhang et al., 2012 [43] | No | China | Asian | 189 | 61 | 165 | 48 | Yes |
Cao et al., 2012 [44] | Yes | China | Asian | 223 | 158 | 147 | 98 | Yes |
Yin et al., 2012 [45] | Yes | China | Asian | 670 | 426 | 682 | 360 | No |
Liu et al., 2011 [46] | No | China | Asian | 155 | 97 | 140 | 66 | No |
Cai et al., 2009 [47] | Yes | China | Chinese | 130 | 53 | 39 | 8 | Yes |
Lin et al., 2008 [48] | Yes | China | Asian | 50 | 31 | 123 | 50 | Yes |
Luo et al., 2008 [49] | Yes | China | Asian | 442 | 182 | 195 | 57 | Yes |
Tang et al., 2007 [50] | Yes | China | Asian | 252 | 113 | 195 | 57 | Yes |
Markan et al., 2007 [51] | Yes | India | Asian | 153 | 48 | 133 | 28 | Yes |
Hui et al., 2007 [52] | No | Japan | Asian | 261 | 178 | 271 | 167 | Yes |
Xing et al., 2007 [53] | Yes | China | Asian | 695 | 493 | 509 | 327 | No |
Li et al., 2006 [54] | No | China | Asian | 26 | 8 | 30 | 9 | Yes |
Hu et al., 2006 [55] | No | China | Asian | 110 | 55 | 115 | 54 | Yes |
Kalita et al., 2006 [56] | Yes | India | Asian | 28 | 10 | 32 | 11 | Yes |
Lwin et al., 2006 [57] | No | Japan | Asian | 116 | 77 | 219 | 155 | Yes |
Liu et al., 2005 [58] | Yes | China | Asian | 100 | 71 | 100 | 69 | Yes |
Sun et al., 2003 [59] | Yes | China | Asian | 55 | 49 | 46 | 32 | Yes |
Wang et al., 2002 [60] | Yes | China | Asian | 105 | 88 | 46 | 32 | Yes |
Zhan et al., 2000 [61] | No | China | Asian | 127 | 83 | 170 | 108 | Yes |
Kobashi et al., 2000 [62] | Yes | Japan | Asian | 184 | 120 | 215 | 132 | Yes |
Gao et al., 1999 [63] | Yes | China | Asian | 127 | 83 | 170 | 108 | Yes |
Nakata et al., 1998 [64] | No | Japan | Asian | 173 | 110 | 184 | 119 | Yes |
Nishio et al., 1996 [65] | No | Japan | Asian | 47 | 31 | 82 | 53 | Yes |
Europe | ||||||||
Bayramoglu et al., 2015 [66] | Yes | Turkey | White | 125 | 60 | 99 | 43 | Yes |
Husemoen et al., 2014 [67] | Yes | Denmark | White | 4694 | 2463 | 7697 | 3907 | Yes |
Ilhan et al., 2008 [68] | Yes | Turkey | Turk | 78 | 42 | 100 | 28 | Yes |
Marinho et al., 2007 [69] | Yes | Portugal | Portuguese | 64 | 49 | 128 | 71 | Yes |
Nagy et al., 2007 [70] | Yes | Hungary | White | 101 | 52 | 73 | 41 | Yes |
Demir et al., 2006 [71] | Yes | Turkey | White | 100 | 67 | 102 | 59 | Yes |
Cesari et al., 2005 [72] | Yes | Italy | White | 90 | 50 | 90 | 48 | Yes |
Tylicki et al., 2005 [73] | No | Austria/Poland | White | 90 | 50 | 90 | 48 | Yes |
Yilmaz et al., 2004 [74] | Yes | Turkey | White | 64 | 35 | 47 | 23 | Yes |
Frederiksen et al., 2004 [75] | Yes | Denmark | White | 1267 | 691 | 7971 | 4120 | Yes |
Rodriguez-Esparragon et al., 2003 [76] | No | Spain | White | 232 | 149 | 215 | 120 | Yes |
Kahleova et al., 2002 [77] | Yes | Czech Republic | White | 164 | 82 | 173 | 87 | Yes |
Benes et al., 2001 [78] | No | Czech Republic | White | 193 | 120 | 209 | 123 | No |
Zusterzeel et al., 2000 [79] | Yes | Netherlands | White | 76 | 44 | 403 | 198 | Yes |
Middle East | ||||||||
Alghasham et al., 2012 [80] | Yes | Saudi Arabia | Qassim | 123 | 50 | 250 | 65 | Yes |
Fakhrzadeh et al., 2009 [81] | Yes | Iran | Asian | 160 | 61 | 76 | 40 | Yes |
North America | ||||||||
Perez-Razo et al., 2015 [82] | Yes | Mexico | Mexican | 569 | 423 | 590 | 465 | Yes |
Vazquez-Alaniz et al., 2014 [83] | Yes | Mexico | Mixed | 194 | 132 | 194 | 140 | Yes |
Deshmukh et al., 2009 [84] | Yes | United States | White | 42 | 20 | 118 | 66 | Yes |
Canto et al., 2008 [85] | Yes | Mexico | White | 125 | 89 | 274 | 213 | Yes |
Rajkovic et al., 2000 [86] | Yes | United States | American | 171 | 29 | 183 | 32 | Yes |
Powers et al., 1999 [87] | Yes | United States | American | 122 | 76 | 114 | 60 | Yes |
Oceania | ||||||||
Fowdar et al., 2012 [88] | No | Australia | White | 377 | 207 | 393 | 218 | Yes |
Ng et al., 2009 [89] | Yes | Australia | White | 38 | 24 | 80 | 40 | Yes |
Heux et al., 2004 [90] | Yes | New Zealand | White | 247 | 160 | 249 | 144 | Yes |
South America | ||||||||
Rios et al., 2017 [91] | Yes | Brazil | American | 96 | 83 | 85 | 65 | Yes |
Fridman et al., 2013 [92] | Yes | Argentina | White | 75 | 46 | 150 | 79 | Yes |
Fridman et al., 2008 [93] | No | Argentina | White | 40 | 25 | 86 | 47 | Yes |
Soares et al., 2008 [94] | Yes | Brazil | American | 30 | 17 | 16 | 7 | Yes |
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Mabhida, S.E.; Muhamed, B.; Sharma, J.R.; Apalata, T.; Nomatshila, S.; Mabasa, L.; Benjeddou, M.; Masilela, C.; Ziqubu, K.; Shabalala, S.; et al. Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature. Genes 2022, 13, 631. https://doi.org/10.3390/genes13040631
Mabhida SE, Muhamed B, Sharma JR, Apalata T, Nomatshila S, Mabasa L, Benjeddou M, Masilela C, Ziqubu K, Shabalala S, et al. Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature. Genes. 2022; 13(4):631. https://doi.org/10.3390/genes13040631
Chicago/Turabian StyleMabhida, Sihle E., Babu Muhamed, Jyoti R. Sharma, Teke Apalata, Sibusiso Nomatshila, Lawrence Mabasa, Mongi Benjeddou, Charity Masilela, Khanyisani Ziqubu, Samukelisiwe Shabalala, and et al. 2022. "Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature" Genes 13, no. 4: 631. https://doi.org/10.3390/genes13040631