Twenty-Five Years of Contemplating Genotype-Based Hereditary Hemochromatosis Population Screening
Round 1
Reviewer 1 Report
The paper can be treated as an important contribution to the discussion on the type and scale of screening tests in hereditary haemochromatosis. However, data relevant to the assertion that “HH remains to be a life-threatening condition that often goes undetected at a curable stage” (as authors conclude) is clearly missing.
Please add the source(s) of this statement relevant to the published results.
Author Response
I have added a reference [61] to HH underdiagnosis at the very end of the manuscript.Reviewer 2 Report
The topic is important, up-to-date, and still rise a discussion. The defined by the author role of the manuscript, which is to "illustrate the controversial discussion surrounding 60 population screening for HH" is fulfilled and several aspects of the topic are presented. The conclusion are resulting from the text.
I have just a few minor comments:
Line 26 Please provide the MIM number in the correct format: MIM# 235200
Line 39 Between around-either between or around
Line 167-178,197-203, 215-222- I would shorten and rephrase the citations
Line 343-344 none of the above professional organizations cited above-"above" is repeated
Line 398 the name Krawczak is misspelled
Author Response
The MIM# Format has been corrected. Between/around was replaced by around ... to The three citations were paraphrased and shortened One "above" was deleted "Krawczak" is now spelled correctly