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10.3390/genes14040909
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Article

The Effect of Fetal Bovine Acellular Dermal Matrix Seeded with Wharton’s Jelly Mesenchymal Stem Cells for Healing Full-Thickness Skin Wounds

by
Reyhaneh Nassiri Mansour
1,
Elham Hasanzadeh
1,
Mozhgan Abasi
1,
Mazaher Gholipourmalekabadi
2,3,4,
Amir Mellati
1,5,* and
Seyed Ehsan Enderami
6,*
1
Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari 4815733971, Iran
2
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 1449614535, Iran
3
Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran
4
Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran
5
Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 4815733971, Iran
6
Immunogenetics Research Center, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari 4815733971, Iran
*
Authors to whom correspondence should be addressed.
Genes 2023, 14(4), 909; https://doi.org/10.3390/genes14040909
Submission received: 5 March 2023 / Revised: 23 March 2023 / Accepted: 7 April 2023 / Published: 13 April 2023
(This article belongs to the Section Molecular Genetics and Genomics)
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Abstract

The treatment of full-thickness skin wounds is a problem in the clinical setting, as they do not heal spontaneously. Extensive pain at the donor site and a lack of skin grafts limit autogenic and allogeneic skin graft availability. We evaluated fetal bovine acellular dermal matrix (FADM) in combination with human Wharton’s jelly mesenchymal stem cells (hWJ-MSCs) to heal full-thickness skin wounds. FADM was prepared from a 6-month-old trauma-aborted fetus. WJ-MSCs were derived from a human umbilical cord and seeded on the FADM. Rat models of full-thickness wounds were created and divided into three groups: control (no treatment), FADM, and FADM-WJMSCs groups. Wound treatment was evaluated microscopically and histologically on days 7, 14, and 21 post-surgery. The prepared FADM was porous and decellularized with a normal range of residual DNA. WJ-MSCs were seeded and proliferated on FADM effectively. The highest wound closure rate was observed in the FADM-WJMSC group on days 7 and 14 post-surgery. Furthermore, this group had fewer inflammatory cells than other groups. Finally, in this study, we observed that, without using the differential cell culture media of fibroblasts, the xenogeneic hWJSCs in combination with FADM could promote an increased rate of full-thickness skin wound closure with less inflammation.
Keywords: acellular dermal matrix; Wharton’s jelly mesenchymal stem cells; skin wounds; wound healing; regenerative medicine acellular dermal matrix; Wharton’s jelly mesenchymal stem cells; skin wounds; wound healing; regenerative medicine

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MDPI and ACS Style

Mansour, R.N.; Hasanzadeh, E.; Abasi, M.; Gholipourmalekabadi, M.; Mellati, A.; Enderami, S.E. The Effect of Fetal Bovine Acellular Dermal Matrix Seeded with Wharton’s Jelly Mesenchymal Stem Cells for Healing Full-Thickness Skin Wounds. Genes 2023, 14, 909. https://doi.org/10.3390/genes14040909

AMA Style

Mansour RN, Hasanzadeh E, Abasi M, Gholipourmalekabadi M, Mellati A, Enderami SE. The Effect of Fetal Bovine Acellular Dermal Matrix Seeded with Wharton’s Jelly Mesenchymal Stem Cells for Healing Full-Thickness Skin Wounds. Genes. 2023; 14(4):909. https://doi.org/10.3390/genes14040909

Chicago/Turabian Style

Mansour, Reyhaneh Nassiri, Elham Hasanzadeh, Mozhgan Abasi, Mazaher Gholipourmalekabadi, Amir Mellati, and Seyed Ehsan Enderami. 2023. "The Effect of Fetal Bovine Acellular Dermal Matrix Seeded with Wharton’s Jelly Mesenchymal Stem Cells for Healing Full-Thickness Skin Wounds" Genes 14, no. 4: 909. https://doi.org/10.3390/genes14040909

APA Style

Mansour, R. N., Hasanzadeh, E., Abasi, M., Gholipourmalekabadi, M., Mellati, A., & Enderami, S. E. (2023). The Effect of Fetal Bovine Acellular Dermal Matrix Seeded with Wharton’s Jelly Mesenchymal Stem Cells for Healing Full-Thickness Skin Wounds. Genes, 14(4), 909. https://doi.org/10.3390/genes14040909

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